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Cerenin5 mg
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Medicine overview
Indications of Cerenin 5 mg
Acute Cerebro-Vascular Accidents (Strokes): Ischaemic strokes due to cerebral thrombosiscerebral embolismacute circulatory disorderhypertensive crisisthe acute cardiovascular disordersischaemic neurological defcitcomplete stroke (CS)multiinfarct dementiacerebral embolismacute circulatory disorderhypertensive crisisthe acute cardiovascular disordersischaemic neurological defcitcomplete stroke (CS)multiinfarct dementiacerebral arteriosclerosishypertensive encephalopathymemory disturbancesslow thinkinglack of concentrationdizzinessmood instabilityaphasiasleep disturbancesmacula degenerationsmeniere's diseasecochleovestibular neuritistinnitus and dizziness of labirynth origin.
Theropeutic Class
Cerebral vasodilator & Neurosensory oxygenator drugs
Pharmacology
Cerenin 5 mg increases cerebral metabolism; it increases glucose and O2 consumption; improves cerebral hypoxia tolerance; shifts glucose metabolism to the energetically more favourable aerobic pathway, but it increases the anaerobic pathway as well; it elevates the ATP concentration and the ATP/AMP ratio in the brain, and elevates the cerebral norepinephrine, dopamine and serotonin levels.
Absorption
Cerenin 5 mg considerably improves cerebral microcirculation by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, and increases erythrocyte deformability.
Distribution
It also promotes O2 transport into the tissues by reducing the O2 affinity of erythrocytes.
Metabolism
It does not elicit steal phenomenon; on the contrary, it primarily improves the blood supply of the injured and ischaemic area while it remains unchanged in the intact areas (inverse steal effect).
Excretion
It further increases blood flow which is already increased as a result of hypoxia.
Dosage & Administration of Cerenin 5 mg
Cerenin 5 mg is taken 15-30 mg daily in 3 divided doses with meals. The maintenance dose is 15 mg three times daily over long periods.
Dosage of Cerenin 5 mg
Tablet
Dosage:1-2 tablets thrice daily, the maintenance dose is 1 tablet thrice daily
IM Injection
Dosage:Daily dose of 20-40 mg are to be given until improvement of symptoms is reached (for not longer than 10 days) then oral treatment should be applied
Notes:If this regimen fails, infusion treatment should be started
IV Infusion
Dosage:The daily starting dose is 20 mg in slow drip infusion (2 ampoules in 500-1000 ml infusion solution)
Notes:This dose can be increased to 1 mg/kg body weight during 3 to 4 days. Treatment should be continued for 10-14 days depending on the tolerance of the patients and the dose should be gradually reduced before discontinuation of treatment
| Condition | Dosage | Notes |
|---|---|---|
| Tablet | 1-2 tablets thrice daily, the maintenance dose is 1 tablet thrice daily | |
| IM Injection | Daily dose of 20-40 mg are to be given until improvement of symptoms is reached (for not longer than 10 days) then oral treatment should be applied | If this regimen fails, infusion treatment should be started |
| IV Infusion | The daily starting dose is 20 mg in slow drip infusion (2 ampoules in 500-1000 ml infusion solution) | This dose can be increased to 1 mg/kg body weight during 3 to 4 days. Treatment should be continued for 10-14 days depending on the tolerance of the patients and the dose should be gradually reduced before discontinuation of treatment |
Interaction of Cerenin 5 mg
The injection is chemically incompatible with heparin, therefore, it should not be injected in the same syringe.
Contraindications
Parenteral treatment- Severe ischaemic heart disease, severe rhythm disorders and pregnancy.
Side Effects of Cerenin 5 mg
Transient hypotension, tachycardia may occur.
Pregnancy & Lactation
Pregnancy category- Not classified
Precautions & Warnings
In the acute stage until the improvement of symptoms parenteral treatment is recommended followed by oral treatment. In chronic cases oral therapy should be applied.
Storage Conditions
Store in a cool and dry place, protected from light and moisture.
Drug Classes
Cerebral vasodilator & Neurosensory oxygenator drugs
Mode Of Action
Cerenin 5 mg increases cerebral metabolism; it increases glucose and O2 consumption; improves cerebral hypoxia tolerance; shifts glucose metabolism to the energetically more favourable aerobic pathway, but it increases the anaerobic pathway as well; it elevates the ATP concentration and the ATP/AMP ratio in the brain, and elevates the cerebral norepinephrine, dopamine and serotonin levels.Cerenin 5 mg considerably improves cerebral microcirculation by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, and increases erythrocyte deformability. It also promotes O2 transport into the tissues by reducing the O2 affinity of erythrocytes.It selectively and intensely increases cerebral blood flow and the share of the brain in cardiac output, it reduces cerebral vascular resistance without affecting systemic circulation (blood pressure, heart rate, cardiac output, total peripheral resistance). It does not elicit steal phenomenon; on the contrary, it primarily improves the blood supply of the injured and ischaemic area while it remains unchanged in the intact areas (inverse steal effect). It further increases blood flow which is already increased as a result of hypoxia.
Pregnancy
In Pregnancy and Lactation the drug is contraindicated.
Frequently Asked Questions
What is Cerenin 5 mg used for?
Acute Cerebro-Vascular Accidents (Strokes): Ischaemic strokes due to cerebral thrombosis, cerebral embolism, acute circulatory disorder, hypertensive crisis; the acute cardiovascular disorders, ischaemic neurological defcit, complete stroke (CS), multiinfarct dementia, cerebral arteriosclerosis ... Read moreAcute Cerebro-Vascular Accidents (Strokes): Ischaemic strokes due to cerebral thrombosis, c…
What is the dosage of Cerenin 5 mg?
Tablet: 1-2 tablets thrice daily, the maintenance dose is 1 tablet thrice daily.IM Injection: Daily dose of 20-40 mg are to be given until improvement of symptoms is reached (for not longer than 10 days) then oral treatment should be applied. If this regimen fails, infusion treatment should be started.IV Infusion: The daily starting dose is 20 mg in slow drip infusion (2 ampoules in 500-1000 ml in…
What are the side effects of Cerenin 5 mg?
Transient hypotension, tachycardia may occur.
Who should not take Cerenin 5 mg?
Parenteral treatment- Severe ischaemic heart disease, severe rhythm disorders and pregnancy.
What precautions should be taken with Cerenin 5 mg?
In the acute stage until the improvement of symptoms parenteral treatment is recommended followed by oral treatment. In chronic cases oral therapy should be applied.
Is Cerenin 5 mg safe during pregnancy and breastfeeding?
Pregnancy category- Not classified
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.