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Cibrate100 mg
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Medicine overview
Indications of Cibrate 100 mg
Ciprofbrate is indicated as an adjunct to diet, exercise and weight reduction for the following:
Treatment of severe hypertriglyceridemia with or without low HDL cholesterol.
Mixed hyperlipidemia when a statin is contraindicated or not tolerated.
Dosage of Cibrate 100 mg
Adults
Dosage:The recommended dose is Ciprofbrate 100 mg per day
Notes:This dose should not be exceeded
Patients with renal insufficiency
Dosage:In moderate renal impairment (creatinine clearance 30-80 ml/min/1.73 m2) it is recommended that dosage be reduced to one tablet every other day
Notes:Patients should be carefully monitored. Ciprofbrate should not be used in severe renal impairment (creatinine clearance <30 ml/min/1.73 m2)
Patients with hepatic insufficiency
Dosage:Use with caution in patients with impaired hepatic function
Notes:Ciprofbrate treatment should be discontinued in case of increased AST and ALT levels to more than 3 times the upper limit of normal or if cholestatic liver injury is evidenced
Elderly
Dosage:As for adults but precautions should be taken for Age more than 70 years
Paediatric population
Dosage:Not recommended since safety and efficacy in children has not been established
| Condition | Dosage | Notes |
|---|---|---|
| Adults | The recommended dose is Ciprofbrate 100 mg per day | This dose should not be exceeded |
| Patients with renal insufficiency | In moderate renal impairment (creatinine clearance 30-80 ml/min/1.73 m2) it is recommended that dosage be reduced to one tablet every other day | Patients should be carefully monitored. Ciprofbrate should not be used in severe renal impairment (creatinine clearance <30 ml/min/1.73 m2) |
| Patients with hepatic insufficiency | Use with caution in patients with impaired hepatic function | Ciprofbrate treatment should be discontinued in case of increased AST and ALT levels to more than 3 times the upper limit of normal or if cholestatic liver injury is evidenced |
| Elderly | As for adults but precautions should be taken for Age more than 70 years | |
| Paediatric population | Not recommended since safety and efficacy in children has not been established |
Interaction of Cibrate 100 mg
Other fibrates & HMG CoA reductase inhibitors: As Risk of myopathy, rhabdomyolysis and myoglobinuria may be increased if Ciprofbrate is used in combination with other fibrates and HMG CoA reductase inhibitors.Oral anticoagulant therapy: Caution should be exercised when Ciprofbrate is taken with oral anticoagulants. Concomitant oral anticoagulant therapy should be given at a reduced dosage and adjusted according to INR.
Contraindications
Hypersensitivity to the active substance or to any of the excipients
Severe hepatic impairment
Severe renal impairment (creatinine clearance <30 ml/min/1.73 m2)
Pregnancy and lactation or when pregnancy is suspected
Concurrent use with another fibrate
Side Effects of Cibrate 100 mg
Headache, Dizziness, Somnolence, Vertigo, Nausea, Vomiting, Diarrhoea, Dyspepsia, Abdominal pain, Rash, Alopecia, Myalgia, Fatigue.
Precautions & Warnings
Special warnings: Patients with rare hereditary problems of galactose intolerance, lactose deficiency or glucose-galactose malabsorption should not take this medicine.Myalgia/myopathy: Patients should be advised to report unexplained muscle pain, tenderness or weakness immediately.Patients with impaired hepatic function: Periodic hepatic function tests are recommended (every 3 months for the first 12 months of treatment). Ciprofbrate treatment should be discontinued in case of increased AST and ALT levels to more than 3 times the upper limit of normal or if cholestatic liver injury is evidenced.
Storage Conditions
Store below 30°C. Protect from light and moisture. Keep the medicine out of reach of children.
Mode Of Action
Ciprofbrate reduces both LDL & VLDL and hence the levels of triglyceride and cholesterol associated with these lipoprotein fractions.
Absorption
It also increases levels of HDL cholesterol.
Distribution
Ciprofbrate is effective in the treatment of hyperlipidemia associated with high plasma concentrations of LDL and VLDL.
Metabolism
There is evidence that treatment with fibrates may reduce coronary heart disease events.
Pregnancy
There is no evidence that Ciprofbrate is teratogenic but signs of toxicity at high doses were observed in teratogenicity tests in animals. As there are no data on its use in human pregnancy, Ciprofbrate is contraindicated during pregnancy. As there are no data on its use in lactation, Ciprofbrate is contraindicated in nursing mothers.
Frequently Asked Questions
What is Cibrate 100 mg used for?
Ciprofbrate is indicated as an adjunct to diet, exercise and weight reduction for the following: Treatment of severe hypertriglyceridemia with or without low HDL cholesterol. Mixed hyperlipidemia when a statin is contraindicated or not tolerated.
What is the dosage of Cibrate 100 mg?
Adults: The recommended dose is Ciprofbrate 100 mg per day. This dose should not be exceeded.Patients with renal insufficiency: In moderate renal impairment (creatinine clearance 30-80 ml/min/1.73 m2) it is recommended that dosage be reduced to one tablet every other day. Patients should be carefully monitored. Ciprofbrate should not be used in severe renal impairment (creatinine clearance <30 ml/…
What are the side effects of Cibrate 100 mg?
Headache, Dizziness, Somnolence, Vertigo, Nausea, Vomiting, Diarrhoea, Dyspepsia, Abdominal pain, Rash, Alopecia, Myalgia, Fatigue.
Who should not take Cibrate 100 mg?
Hypersensitivity to the active substance or to any of the excipients Severe hepatic impairment Severe renal impairment (creatinine clearance <30 ml/min/1.73 m2) Pregnancy and lactation or when pregnancy is suspected Concurrent use with another fibrate
What precautions should be taken with Cibrate 100 mg?
Special warnings: Patients with rare hereditary problems of galactose intolerance, lactose deficiency or glucose-galactose malabsorption should not take this medicine.Myalgia/myopathy: Patients should be advised to report unexplained muscle pain, tenderness or weakness immediately.Patients with impaired hepatic function: Periodic hepatic function tests are recommended (every 3 months for the first…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.