Indications of Delice 5% w/w
Delice 5% w/w cream is indicated for the treatment of scabies and crab lice infestations (Pediculosis). Scabies can affect everyone in the family. If one is infected, all family members must be treated together.
Delice 5% w/w induces electrochemical abnormalities across the membranes of excitable cells, leading to sensory hyperexcitability, in coordination and prostration. Delice 5% w/w is rapidly metabolized in mammals by ester hydrolysis to inactive metabolites which are excreted primarily in the urine. The principal metabolites of Delice 5% w/w are detectable in the urine within hours of a whole body application of the cream to healthy volunteers or scabies patients. The highest levels of excretion are detectable within the first 48 hours, but very low levels of metabolites are still detectable in the urine of some individuals 28 days after treatment.
Dosage of Delice 5% w/w
Recommended duration of Treatment:
Adults and children over 12 years: a full tube
Children aged 6-12 years: up to 1⁄2 of a tube
Children aged 1-5 years: up to ¼ of a tube
Children aged 2 months to 1 year: up to ⅛ of a tube
Children Less then 2 month: dose is not established
Administration of Delice 5% w/w
Before application of Delice 5% w/w cream the skin should be clean, cool and dry. Do not have a hot shower or bath before applying. For adults and children over 2 years: Apply the cream to the whole body from the neck down, rubbing lightly into the skin until the cream disappears. It is important to include all skin surfaces, such as between the fingers and toes, under the nails and on the soles of the feet. For babies under 2 years: Apply to the face, neck, ears and scalp as well, only avoiding the area immediately around the eyes and mouth.Leave cream on for at least 8 hours, before washing off. Reapply to any area that may be washed during the 8h treatment time (such as after washing the hands). If necessary, Delice 5% w/w cream should be used again after 7 days as per the advice of the doctor.
Interaction of Delice 5% w/w
The treatment of eczemodous like reactions with corticosteroids should be withheld prior to treatment with Delice 5% w/w, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite.
Delice 5% w/w is contraindicated in patients with known hypersensitivity to any component of pyrethroids or Delice 5% w/w. Nursing staff who routinely apply Delice 5% w/w may wear globes to avoid any possible irritation to the hands.
Side Effects of Delice 5% w/w
In Scabies patients, skin discomfort, usually described as burning, stinging or tingling occurs in a few individuals soon after the cream is applied. Others transient signs and symptoms of irritation including enythema, edema, eczema, rash and puritis.
Pregnancy & Lactation
There are limited data on the use of Delice 5% w/w in pregnancy which provide no indication of any risk to the foetus. Furthermore, the amount of Delice 5% w/w absorbed systemically following a whole body application is extremely low. The negative mutagenicity tests and the very low mammalian toxicity would suggest that any risk to the foetus following treatment with Delice 5% w/w is minimal. Inspite of these, Delice 5% w/w is suggested not to useduring pregnancy.It is not known whether Delice 5% w/w is excreted in human breast milk. So, it should not be used in nursing mothers.
Precautions & Warnings
Scabies infestation is often accompanied by pruritus, edema & erythema. Treatment with Delice 5% w/w may temporarily exacerbate these conditions. Patients should be advised to avoid contact with eyes during application & to flash with water immediately if the cream gets in the eyes.
Overdose Effects of Delice 5% w/w
There are no reports of overdosage with Delice 5% w/w. It is possible that excessive application of Delice 5% w/w might result in localized adverse reactions or more severe skin reactions.
Store in a cool, dry place, away from light & keep out of the reach of children...
Mode Of Action
Delice 5% w/w cream contains Delice 5% w/w, a pyrethroid, which is a topical scabicidal agent for the treatment of infestation with Sarcoptes Scabiei (scabies). It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization & paralysis of the pests are the consequences of this disturbance.Pharmacokinetics: The only approved route of administration is the topical route and there are few human data available on systemic exposure or kinetics following Delice 5% w/w application to the skin. Some presystemic metabolism occurs in skin. Less than 0.5% of applied Delice 5% w/w is absorbed during the first 48 hours. Absorbed Delice 5% w/w is rapidly metabolized by ester hydrolysis, most likely in the liver and the products are excreted primarily in the urine.
In the absence of specific studies in pregnant women, its use in pregnancy should only follow medical advice. It is not known whether Delice 5% w/w is excreted in human milk so it should not be used in nursing mothers.