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Medicine overview
Indications of Diar 500 mg
Diar 500 mg is indicated for the treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia and Entamoeba histolytica.
Theropeutic Class
Anti-diarrhoeal Antiprotozoal
Pharmacology
Diar 500 mg is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Diar 500 mg is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Diar 500 mg and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage & Administration of Diar 500 mg
Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days. Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days.Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days. It is recommended to be administered with food.
Dosage of Diar 500 mg
Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days. Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days.Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days. It is recommended to be administered with food.
Interaction of Diar 500 mg
It is highly bound to plasma protein. Therefore, caution should be exercised when administering Diar 500 mg concurrently with other highly plasma protein-bound drugs with narrow therapeutic index.
Contraindications
It is contraindicated in patients with known hypersensitivity to Diar 500 mg or any components of the preparation.
Side Effects of Diar 500 mg
The most frequent side effects, reported by Diar 500 mg are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Pregnancy & Lactation
US FDA pregnancy category of Diar 500 mg is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Diar 500 mg have been shown to be excreted in human milk. So, caution should be exercised when Diar 500 mg is administered during lactation.
Precautions & Warnings
Diar 500 mg must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Classes
Anti-diarrhoeal Antiprotozoal
Mode Of Action
Diar 500 mg is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Diar 500 mg is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Diar 500 mg and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Pregnancy
US FDA pregnancy category of Diar 500 mg is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Diar 500 mg have been shown to be excreted in human milk. So, caution should be exercised when Diar 500 mg is administered during lactation.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
