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Zox500 mg
Square Pharmaceuticals PLC.
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Zoana500 mg
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Medicine overview
Indications of Zoana 500 mg
Zoana 500 mg is indicated for the treatment of diarrhea caused by Cryptosporidium parvumGiardia lamblia and Entamoeba histolytica.
Theropeutic Class
Anti-diarrhoeal Antiprotozoal
Pharmacology
Zoana 500 mg is a synthetic antiprotozoal agent for oral administration.
Absorption
The antiprotozoal activity of Zoana 500 mg is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction.
Metabolism
This reaction is essential for anaerobic energy metabolism of the protozoa. Zoana 500 mg and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage & Administration of Zoana 500 mg
Age 1-3 years
Dosage:1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
Age 4-11 years
Dosage:2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
Age 12 years or above
Dosage:5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
Notes:It is recommended to be administered with food
| Condition | Dosage | Notes |
|---|---|---|
| Age 1-3 years | 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days | |
| Age 4-11 years | 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days | |
| Age 12 years or above | 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days | It is recommended to be administered with food |
Dosage of Zoana 500 mg
Age 1-3 years
Dosage:1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
Age 4-11 years
Dosage:2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
Age 12 years or above
Dosage:5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
Notes:It is recommended to be administered with food
| Condition | Dosage | Notes |
|---|---|---|
| Age 1-3 years | 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days | |
| Age 4-11 years | 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days | |
| Age 12 years or above | 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days | It is recommended to be administered with food |
Interaction of Zoana 500 mg
It is highly bound to plasma protein. Therefore, caution should be exercised when administering Zoana 500 mg concurrently with other highly plasma protein-bound drugs with narrow therapeutic index.
Contraindications
It is contraindicated in patients with known hypersensitivity to Zoana 500 mg or any components of the preparation.
Side Effects of Zoana 500 mg
The most frequent side effects, reported by Zoana 500 mg are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Pregnancy & Lactation
US FDA pregnancy category of Zoana 500 mg is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Zoana 500 mg have been shown to be excreted in human milk. So, caution should be exercised when Zoana 500 mg is administered during lactation.
Precautions & Warnings
Zoana 500 mg must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Classes
Anti-diarrhoeal Antiprotozoal
Mode Of Action
Zoana 500 mg is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Zoana 500 mg is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Zoana 500 mg and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Pregnancy
US FDA pregnancy category of Zoana 500 mg is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Zoana 500 mg have been shown to be excreted in human milk. So, caution should be exercised when Zoana 500 mg is administered during lactation.
Frequently Asked Questions
What is Zoana 500 mg used for?
Nitazoxanide is indicated for the treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia and Entamoeba histolytica.
What is the dosage of Zoana 500 mg?
Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days. Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days.Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days. It is recommended to be administered with food.
What are the side effects of Zoana 500 mg?
The most frequent side effects, reported by Nitazoxanide are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Who should not take Zoana 500 mg?
It is contraindicated in patients with known hypersensitivity to Nitazoxanide or any components of the preparation.
What precautions should be taken with Zoana 500 mg?
Nitazoxanide must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Is Zoana 500 mg safe during pregnancy and breastfeeding?
US FDA pregnancy category of Nitazoxanide is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nitazoxanide have been shown to be excreted in human milk. So, caution should be exercised when Nitazoxanide is administered d…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.