Fliban100 mg

Fliban 100 mg is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to: A co-existing medical or psychiatric condition, ... Read moreFliban 100 mg is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to: A co-existing medical or psychiatric condition, Problems within the relationship, or The effects of a medication or other drug substance. Acquired HSDD refers to HSDD that develops in a patient who previously had no problems with sexual desire. Generalized HSDD refers to HSDD that occurs regardless of the type of stimulation, situation or partner.

The recommended dosage of Fliban 100 mg is 100 mg administered orally once per day at bedtime. Fliban 100 mg is dosed at bedtime because administration during waking hours increases the risks of hypotension, syncope, accidental injury, and central nervous system (CNS) depression (such as somnolence and sedation). If a dose of Fliban 100 mg is missed at bedtime, instruct the patient to take the next dose at bedtime on the next day. Instruct the patient to not double the next dose.Pediatric Use: Fliban 100 mg is not indicated for use in pediatric patients.Geriatric Use: Fliban 100 mg is not indicated for use in geriatric patients. Safety and effectiveness have not been established in geriatric patients.

Oral Contraceptives and Other Weak CYP3A4 Inhibitors: Increases Fliban 100 mg exposures and incidence of adverse reactions. Strong CYP2C19 Inhibitors: Increases Fliban 100 mg exposure which may increase risk of hypotension, syncope, and CNS depression. CYP3A4 Inducers: Use of Fliban 100 mg not recommended; Fliban 100 mg concentrations substantially reduced. Digoxin: Increases digoxin concentrations, which may lead to digoxin toxicity. Increase monitoring of digoxin concentrations.

Fliban 100 mg is contraindicated: with use of alcohol, with concomitant use with moderate or strong CYP3A4 inhibitors, in patients with hepatic impairment.

Most common adverse reactions are Dizziness, Somnolence, Nausea, Fatigue, Insomnia, Dry mouth.

Hypotension and Syncope with Fliban 100 mg Alone: Patients with pre-syncope should immediately lie supine and promptly seek medical help if symptoms do not resolve.Central Nervous System (CNS) Depression (e.g., Somnolence, Sedation): Can occur with Fliban 100 mg alone. Exacerbated by other CNS depressants, and in settings where Fliban 100 mg concentrations are increased. Patients should avoid activities requiring full alertness (e.g., operating machinery or driving) until at least 6 hours after each dose and until they know how Fliban 100 mg affects them.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, Fliban 100 mg binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), Fliban 100 mg may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.

There are no studies of Fliban 100 mg in pregnant women to inform whether there is a drug-associated risk in humans. Fliban 100 mg is excreted in rat milk. It is unknown whether Fliban 100 mg is present in human milk, whether Fliban 100 mg has effects on the breastfed infant, or whether Fliban 100 mg affects milk production. Because of the potential for serious adverse reactions including sedation in a breastfed infant, breastfeeding is not recommended during treatment with Fliban 100 mg.