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Konakion2 mg/0.2 ml
Injection
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Medicine overview
Indications of Konakion 2 mg/0.2 ml
VIIIX and X) of various etiologiesincluding overdosage of courmarin-type anticoagulantstheir combination with phenylbutazoneand other forms of hypovitaminosis K (e.g. in obstructive jaundice as well as liver and intestinal disordersand after prolonged treatment with antibioticssulphonamides or salicylates). Prevention and treatment of bleeding due to vitamin K deficiency.
Theropeutic Class
Vitamin-K Preparations
Pharmacology
Konakion 2 mg/0.2 ml is a procoagulant factor.
Absorption
Lack of Konakion 2 mg/0.2 ml leads to an increased tendency to haemorrhagic disease in the newborn.
Metabolism
As a component of a hepatic carboxylase system, Konakion 2 mg/0.2 ml is involved in the post translational carboxylation of clotting factors II (prothrombin), VII, IX and X and the clotting inhibitors protein C and protein S. Konakion 2 mg/0.2 ml is ineffective in hereditary hypoprothrombinemia or hypoprothrombinemia induced by severe hepatic failure. Konakion 2 mg/0.2 ml administration, which promotes synthesis of the above-mentioned coagulation factors by the liver, can reverse an abnormal coagulation status and bleeding due to Konakion 2 mg/0.2 ml deficiency.
Dosage & Administration of Konakion 2 mg/0.2 ml
Prophylaxis
Dosage:Mild Hemorrhage or hemorrhagic tendency: The usual dose for Neonates is 2 mg orally at or just after birth
Notes:Then 2 mg on 4th-5th day and another 2 mg on 28th-30th day orally. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route
Children over 1 year of age
Dosage:Could be given 5-10 mg orally
Notes:A single 1 mg (0.1 ml) dose IM is recommended in children who are not assured of receiving a second oral dose or, in the case of breast-fed children, who are not assured of receiving a third oral dose
Therapy
Dosage:Initially, 1 mg by intravenous injection, with further doses as required, based on the clinical picture and coagulation status
Neonates with special risk factors
Dosage:Pre-maturity, birth asphyxia (inadequate intake of oxygen by the baby during birth process), obstructive jaundice, inability to swallow, maternal use of anticoagulants or anti-epileptics- 1 mg intramuscularly or intravenously at birth or shortly after birth if the oral route is unsuitable
Notes:Intramuscular and intravenous doses should not exceed 0.4 mg/kg in premature infants weighing less than 2.5 kg. The size and frequency of further doses should be based on coagulation status To ensure a total protection of the newborns, 3 prophylactic doses of Vitamin K should be administered orally following the dosing schedule mentioned above
| Condition | Dosage | Notes |
|---|---|---|
| Prophylaxis | Mild Hemorrhage or hemorrhagic tendency: The usual dose for Neonates is 2 mg orally at or just after birth | Then 2 mg on 4th-5th day and another 2 mg on 28th-30th day orally. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route |
| Children over 1 year of age | Could be given 5-10 mg orally | A single 1 mg (0.1 ml) dose IM is recommended in children who are not assured of receiving a second oral dose or, in the case of breast-fed children, who are not assured of receiving a third oral dose |
| Therapy | Initially, 1 mg by intravenous injection, with further doses as required, based on the clinical picture and coagulation status | |
| Neonates with special risk factors | Pre-maturity, birth asphyxia (inadequate intake of oxygen by the baby during birth process), obstructive jaundice, inability to swallow, maternal use of anticoagulants or anti-epileptics- 1 mg intramuscularly or intravenously at birth or shortly after birth if the oral route is unsuitable | Intramuscular and intravenous doses should not exceed 0.4 mg/kg in premature infants weighing less than 2.5 kg. The size and frequency of further doses should be based on coagulation status To ensure a total protection of the newborns, 3 prophylactic doses of Vitamin K should be administered orally following the dosing schedule mentioned above |
Interaction of Konakion 2 mg/0.2 ml
Konakion 2 mg/0.2 ml antagonises the effect of coumarin-type anticoagulants. Coadministration of anticonvulsants can impair the action of vitamin K-1.
Contraindications
It is contraindicated in patients with known hypersensitivity to any of its constituents.
Side Effects of Konakion 2 mg/0.2 ml
There are isolated unconfirmed reports on the possible occurrence of anaphylactoid reactions and venous irritation or phlebitis after parenteral use of Konakion 2 mg/0.2 ml injections.
Precautions & Warnings
Careful monitoring of the coagulation parameters is necessary for patients with severely impaired liver function after administration of Konakion 2 mg/0.2 ml .
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Frequently Asked Questions
What is Konakion 2 mg/0.2 ml used for?
Phytomenadione (Vitamin K-1) is indicated in following indications- Prophylaxis and treatment of haemorrhagic disease in the newborn. Haemorrhage or risk of haemorrhage as a result of severe hypoprothrombinemia (i.e. deficiency of clotting factors II, VII, IX and X) of various etiologies, including overdosage of courmarin-type anticoagulants, their combination with phenylbutazone, and other forms …
What is the dosage of Konakion 2 mg/0.2 ml?
Prophylaxis: Mild Hemorrhage or hemorrhagic tendency: The usual dose for Neonates is 2 mg orally at or just after birth. Then 2 mg on 4th-5th day and another 2 mg on 28th-30th day orally. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route. Children over 1 year of age: Could be given 5-10 mg orally. A single 1 mg (0.1 ml) dose IM is recommended in children who a…
What are the side effects of Konakion 2 mg/0.2 ml?
There are isolated unconfirmed reports on the possible occurrence of anaphylactoid reactions and venous irritation or phlebitis after parenteral use of Phytomenadione injections.
Who should not take Konakion 2 mg/0.2 ml?
It is contraindicated in patients with known hypersensitivity to any of its constituents.
What precautions should be taken with Konakion 2 mg/0.2 ml?
Careful monitoring of the coagulation parameters is necessary for patients with severely impaired liver function after administration of Phytomenadione .
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.