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Acepril5 mg
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Lipril5 mg
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Medicine overview
Indications of Lipril 5 mg
includingas appropriatelipid controldiabetes managementantithrombotic therapysmoking cessationexercisesee published guidelinessuch as those of the National High Blood Pressure Education Program’s Joint National Committee on PreventionDetectionEvaluationand Treatment of High Blood Pressure (JNC).Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsand the absolute risk increase per mmHg is greater at higher blood pressuresso the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for examplepatients with diabetes or hyperlipidemia)and many antihypertensive drugs have additional approved indications and effects (e.g.on anginaheart failureas appropriatethe standard recommended treatments such as thrombolyticsaspirin and beta-blockers
Theropeutic Class
Angiotensin-converting enzyme (ACE) inhibitors
Pharmacology
Lipril 5 mg competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion.
Absorption
This promotes vasodilation and BP reduction.
Dosage of Lipril 5 mg
Oral (Adult)- Hypertension
Dosage:Initially, 10 mg/day, 1st dose given preferably at bedtime to avoid precipitous fall in BP
Notes:Patient with renovascular HTN, volume depletion, severe HTN: Initially, 2.5-5 mg once daily
Patient on diuretic
Dosage:Initially, 5 mg once daily
Maintenance
Dosage:20 mg once daily, up to 80 mg/day may be given if needed
Diabetic nephropathy
Dosage:Hypertensive type 2 diabetics with microalbuminuria: 10 mg once daily, may increase to 20 mg once daily to achieve a sitting diastolic BP Heart failure: As adjunct: Initially, 2.5 or 5 mg/day, increased by increments of ≤10 mg at intervals of at least 2 wk to max maintenance dose of 40 mg/day
Post-myocardial infarction
Dosage:Initially, 5 mg once daily for 2 days started within 24 hr of the onset of symptoms
Notes:Increase to 10 mg once daily
Patients with low systolic BP
Dosage:Initially, 2.5 mg once daily
Oral (Child)- Hypertension
Dosage:≥6 yr Initially, 0.07 mg/kg, up to 5 mg once daily
| Condition | Dosage | Notes |
|---|---|---|
| Oral (Adult)- Hypertension | Initially, 10 mg/day, 1st dose given preferably at bedtime to avoid precipitous fall in BP | Patient with renovascular HTN, volume depletion, severe HTN: Initially, 2.5-5 mg once daily |
| Patient on diuretic | Initially, 5 mg once daily | |
| Maintenance | 20 mg once daily, up to 80 mg/day may be given if needed | |
| Diabetic nephropathy | Hypertensive type 2 diabetics with microalbuminuria: 10 mg once daily, may increase to 20 mg once daily to achieve a sitting diastolic BP Heart failure: As adjunct: Initially, 2.5 or 5 mg/day, increased by increments of ≤10 mg at intervals of at least 2 wk to max maintenance dose of 40 mg/day | |
| Post-myocardial infarction | Initially, 5 mg once daily for 2 days started within 24 hr of the onset of symptoms | Increase to 10 mg once daily |
| Patients with low systolic BP | Initially, 2.5 mg once daily | |
| Oral (Child)- Hypertension | ≥6 yr Initially, 0.07 mg/kg, up to 5 mg once daily |
Administration of Lipril 5 mg
May be taken with or without food.
Interaction of Lipril 5 mg
May enhance hypotensive effect with diuretics. May increase risk of renal function deterioration and decrease antihypertensive effect with NSAIDs. May increase serum levels and toxicity of lithium. Increased risk of hyperkalaemia with K-sparing diuretics and K supplements. May increase nitritoid reactions of gold Na thiomalate.
Contraindications
History of angioedema related to previous ACE inhibitor treatment, hereditary or idiopathic angioedema. Concomitant use with aliskiren in patients with diabetes or renal impairment. Pregnancy. Children with GFR <30 mL/min/1.73 m2.
Side Effects of Lipril 5 mg
Headache, fatigue, persistent and non-productive cough, chest and abdominal pain, dizziness, nausea, vomiting, diarrhoea, upper resp tract infection, asthenia, rash, orthostatic effects, hypotension, renal dysfunction, hyperkalaemia, intestinal angioedema; increased BUN and serum creatinine levels.
Pregnancy & Lactation
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Precautions & Warnings
Bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis. Patients with collagen vascular disease, acute MI at risk of further haemodynamic deterioration, angioedema unrelated to ACE inhibitor therapy, aortic stenosis and hypertrophic cardiomyopathy. Increased risk of angioedema in black patients. Renal impairment. Lactation. Childn <6 yr.
Overdose Effects of Lipril 5 mg
Symptoms: Hypotension, tachycardia, circulatory shock, palpitations, bradycardia, hyperventilation, renal failure, electrolyte disturbances, anxiety, dizziness and cough. Management: Normal saline IV infusion may be used. Perform haemodialysis, emesis, gastric lavage, admin of absorbents and Na sulfate if recently taken. Consider admin of angiotensin II infusion and/or IV catecholamines if available.
Storage Conditions
Store at below 25° C.
Use In Special Populations
Adult:
CrCl 10-30 ml/min: Initially, 2.5-5 mg once daily.
CrCl 31-80 ml/min: Initially 5-10 mg once daily. Dose can be adjusted up to max 40 mg once daily based on patient's response.
Child: Do not give if GFR <30 mL/min/1.73 m2.
Drug Classes
Angiotensin-converting enzyme (ACE) inhibitors
Mode Of Action
Lipril 5 mg competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation and BP reduction.
Pregnancy
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Pediatric Uses
Adult:
CrCl 10-30 ml/min: Initially, 2.5-5 mg once daily.
CrCl 31-80 ml/min: Initially 5-10 mg once daily. Dose can be adjusted up to max 40 mg once daily based on patient's response.
Child: Do not give if GFR <30 mL/min/1.73 m2.
Frequently Asked Questions
What is Lipril 5 mg used for?
Hypertension: Lisinopril is indicated for the treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes ... Read moreHypertension: Lisinopril is indicated for the treatment of hypertension in adult patients and pediatric patients 6 years…
What is the dosage of Lipril 5 mg?
Oral (Adult)- Hypertension: Initially, 10 mg/day, 1st dose given preferably at bedtime to avoid precipitous fall in BP. Patient with renovascular HTN, volume depletion, severe HTN: Initially, 2.5-5 mg once daily. Patient on diuretic: Initially, 5 mg once daily. Maintenance: 20 mg once daily, up to 80 mg/day may be given if needed.Diabetic nephropathy: Hypertensive type 2 diabetics with microalbumi…
What are the side effects of Lipril 5 mg?
Headache, fatigue, persistent and non-productive cough, chest and abdominal pain, dizziness, nausea, vomiting, diarrhoea, upper resp tract infection, asthenia, rash, orthostatic effects, hypotension, renal dysfunction, hyperkalaemia, intestinal angioedema; increased BUN and serum creatinine levels.
Who should not take Lipril 5 mg?
History of angioedema related to previous ACE inhibitor treatment, hereditary or idiopathic angioedema. Concomitant use with aliskiren in patients with diabetes or renal impairment. Pregnancy. Children with GFR <30 mL/min/1.73 m2.
What precautions should be taken with Lipril 5 mg?
Bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis. Patients with collagen vascular disease, acute MI at risk of further haemodynamic deterioration, angioedema unrelated to ACE inhibitor therapy, aortic stenosis and hypertrophic cardiomyopathy. Increased risk of angioedema in black patients. Renal impairment. Lactation. Childn <6 yr.
Is Lipril 5 mg safe during pregnancy and breastfeeding?
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.