10% Off
Imotil2 mg
Square Pharmaceuticals PLC.
৳9.00
Add to cart
Best PriceTk /
1
Medicine overview
Indications of Loperin 2 mg
Loperin 2 mg is indicated as a symptomatic treatment of acute and chronic diarrhoea
Theropeutic Class
Anti-diarrhoeal, Anti-motility drugs
Pharmacology
Loperin 2 mg inhibits the peristaltic activity of longitudinal and circular smooth muscle in the intestine by interacting with cholinergic and noncholinergic neuronal mechanisms responsible for producing the peristaltic reflex. Loperin 2 mg binds to the opiate receptor in the gut wall, reducing propulsive peristalsis, and increase intestinal transit time.Loperin 2 mg is orally administered capsule. After administration absorption is more than 65% which occurs at a modest rate, with peak serum levels of 2-3 µgm/litre occurring at about 4 hours later after oral administration. The rest 35% is excreted unchanged in the faeces. Loperin 2 mg undergoes an extensive presystemic first pass metabolism in the gut wall and in the liver. Loperin 2 mg does not act centrally due to its high affinity for the gut wall and its presystemic metabolism. This is why it reaches the systemic circulation in very minute amount. The route of elimination is 0.63-1.4% in urine as unchanged drug, 58% is excreted in the bile and 15-23% appears in the faeces.
Dosage & Administration of Loperin 2 mg
Acute diarrhoea-
The initial dose is 2 capsules for adults and 1 capsule for children older than eight; in addition 1 capsule should be taken at any subsequent loose stool. The daily dose, however should not exceed 8 capsules for adults, for children 4-6 capsules according to age.
Chronic diarrhoea-
Initial dose:
Adults: 2 capsules daily.
Children older than eight: 1 capsule daily.
Maintenance dose: One should aim at obtaining normal stools (e.g., one or two stools of good consistency a day). For this it may be necessary to adjust the initial dose (by increasing or decreasing it as required). Maintenance dose as a rule will vary from 1 to 6 capsules daily
Interaction of Loperin 2 mg
No drugs are known to be incompatible with Loperin 2 mg
Contraindications
It should not be used in children less than 4 years of age. It must not be used when inhibition of peristalsis is to be avoided in particular when constipation are present or when abdominal distension develops particularly severely dehydrated children or in patients with acute ulcerative colitis or pseudomembranous colitis associated with broad spectrum antibiotics. It should not be used alone in acute dysentery associated with blood in stools and elevated temperature.
Side Effects of Loperin 2 mg
On occasions paralytic ileus, abdominal cramps and bloating have been reported. Other side effects observed are skin reactions including urticaria, nausea, vomiting, constipation, tiredness, drowsiness, dizziness and dry mouth.
Pregnancy & Lactation
Safety of use of Loperin 2 mg during pregnancy has not been established, although studies in animal did not demonstrate any teratogenic effects. Therefore, it should not be administered to the patients during pregnancy. Although the fraction of Loperin 2 mg secreted in the human milk is very low, caution is advised if it is to be administered to nursing mothers.
Precautions & Warnings
It should be used with caution in patients with defective hepatic function as this might result in a relative overdose.
Overdose Effects of Loperin 2 mg
Symptoms: CNS depression; constipation, urinary retention and ileus may occur. Management: Employ gastric lavage followed by admin of activated charcoal. Naloxone HCl may be given as antidote.
Storage Conditions
Store between 20-25°C.
Frequently Asked Questions
What is Loperin 2 mg used for?
Loperin 2 mg is indicated as a symptomatic treatment of acute and chronic diarrhoea
What is the dosage of Loperin 2 mg?
Acute diarrhoea- The initial dose is 2 capsules for adults and 1 capsule for children older than eight; in addition 1 capsule should be taken at any subsequent loose stool. The daily dose, however should not exceed 8 capsules for adults, for children 4-6 capsules according to age. Chronic diarrhoea- Initial dose: Adults: 2 capsules daily. Children older than eight: 1 capsule daily. Maintenance dos…
What are the side effects of Loperin 2 mg?
On occasions paralytic ileus, abdominal cramps and bloating have been reported. Other side effects observed are skin reactions including urticaria, nausea, vomiting, constipation, tiredness, drowsiness, dizziness and dry mouth.
Who should not take Loperin 2 mg?
It should not be used in children less than 4 years of age. It must not be used when inhibition of peristalsis is to be avoided in particular when constipation are present or when abdominal distension develops particularly severely dehydrated children or in patients with acute ulcerative colitis or pseudomembranous colitis associated with broad spectrum antibiotics. It should not be used alone in …
What precautions should be taken with Loperin 2 mg?
It should be used with caution in patients with defective hepatic function as this might result in a relative overdose.
Is Loperin 2 mg safe during pregnancy and breastfeeding?
Safety of use of Loperin 2 mg during pregnancy has not been established, although studies in animal did not demonstrate any teratogenic effects. Therefore, it should not be administered to the patients during pregnancy. Although the fraction of Loperin 2 mg secreted in the human milk is very low, caution is advised if it is to be administered to nursing mothers.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.