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Lutisone0.005%
Ointment
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Medicine overview
Indications of Lutisone 0.005%
Lutisone 0.005% is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive eczema or dermatitis.
Theropeutic Class
Fluticasone & combined preparations topical
Pharmacology
Fluticasone propionate is a glucocorticoid with high topical anti-inflammatory potency, but a low HPA-axis suppressive activity after dermal administration.
Absorption
It, therefore, has a therapeutic index which is greater than most of the commonly available steroids. Fluticasone propionate has a high degree of selectivity for the glucocorticoid receptor.
Distribution
In vitro studies show that Lutisone 0.005% has a strong affinity for, and agonist activity at, human glucocorticoid receptors. This receptor is believed to be responsible for the anti-inflammatory properties of glucocorticoids.
Metabolism
The therapeutic potency of glucocorticoids is related to the half-life of the glucocorticoid-receptor complex. The half-life of the Fluticasone propionate glucocorticoid-receptor complex is approximately 10 hours.
Dosage & Administration of Lutisone 0.005%
Cream
Dosage:Apply a thin layer of Fluticasone propionate cream to the affected skin areas once daily
Ointment
Dosage:Apply a thin layer of Fluticasone propionate Ointment to the affected skin areas twice daily
| Condition | Dosage | Notes |
|---|---|---|
| Cream | Apply a thin layer of Fluticasone propionate cream to the affected skin areas once daily | |
| Ointment | Apply a thin layer of Fluticasone propionate Ointment to the affected skin areas twice daily |
Contraindications
Fluticasone propionate is contraindicated in Rosacea, Acne vulgaris, Peri-oral dermatitis, Primary cutaneous viral infections (e.g., herpes simplex, chicken pox), Hypersensitivity to any of the ingredients, Perianal and genital pruritus, etc. The use of Fluticasone propionate is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria and dermatoses in children under one year of age, including deramtitis and napkin eruptions.
Side Effects of Lutisone 0.005%
The Lutisone 0.005% preparations are usually well tolerated; local burning and pruritus have been reported. If signs of hypersensitivity appear, application should be stopped immediately. Prolonged and intensive treatment with potent corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, dilatation of the superficial blood vessels, hypertrichosis and hypopigmentation.Secondary infection, particularly when occlusive dressings are used or when skin folds are involved and allergic contact dermatitis have also been reported with corticosteroid use. Exacerbation of the signs and symptoms of the dermatoses have been reported with corticosteroid use.Prolonged use of large amounts of corticosteroids, or treatment of extensive areas, can result in sufficient systemic absorption to produce the features of hypercorticism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. In infants, the napkin may act as an occlusive dressing.
Pregnancy & Lactation
Administration of Lutisone 0.005% during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus.The excretion of Lutisone 0.005% into human breast milk has not been investigated. Plasma levels in patients following dermal application of Lutisone 0.005% at recommended doses are likely to be low. When Lutisone 0.005% is used in breast feeding mothers, the therapeutic benefits must be weighed against the potential hazards to mother and baby.
Precautions & Warnings
Fluticasone propionate has a very low propensity for systemic absorption, nevertheless, prolonged application of high doses to large areas of body surface, especially in infants and small children might lead to adrenal suppression. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.The face, more than other areas of the body, may exhibit atropic changes after prolonged treatment with potent topical corticosteroids. This must be borne in mind when treating severe eczema.Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions induced by occlusive dressing, and so the skin should be cleansed before a fresh dressing is applied.
Overdose Effects of Lutisone 0.005%
Acute overdosage is very unlikely to occur, however, in case of cronic overdosage or misuse the features of hypercorticism may appear, and in this situation, as with any corticosteroid, application should be discontinued. Overdosage by ingestion of Lutisone 0.005% cream or ointment is extremely unlikely to occur due to the very low oral bioavailability of Lutisone 0.005%.
Storage Conditions
Store below 30˚ C. Do not freeze.
Frequently Asked Questions
What is Lutisone 0.005% used for?
Fluticasone Propionate is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive eczema or dermatitis.
What is the dosage of Lutisone 0.005%?
Cream: Apply a thin layer of Fluticasone propionate cream to the affected skin areas once daily.Ointment: Apply a thin layer of Fluticasone propionate Ointment to the affected skin areas twice daily.
What are the side effects of Lutisone 0.005%?
The fluticasone propionate preparations are usually well tolerated; local burning and pruritus have been reported. If signs of hypersensitivity appear, application should be stopped immediately. Prolonged and intensive treatment with potent corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, dilatation of the superficial blood vessels, hypertrichosis …
Who should not take Lutisone 0.005%?
Fluticasone propionate is contraindicated in Rosacea, Acne vulgaris, Peri-oral dermatitis, Primary cutaneous viral infections (e.g., herpes simplex, chicken pox), Hypersensitivity to any of the ingredients, Perianal and genital pruritus, etc. The use of Fluticasone propionate is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria and dermato…
What precautions should be taken with Lutisone 0.005%?
Fluticasone propionate has a very low propensity for systemic absorption, nevertheless, prolonged application of high doses to large areas of body surface, especially in infants and small children might lead to adrenal suppression. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.The face, more than other areas of the bo…
Is Lutisone 0.005% safe during pregnancy and breastfeeding?
Administration of fluticasone propionate during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus.The excretion of fluticasone propionate into human breast milk has not been investigated. Plasma levels in patients following dermal application of fluticasone propionate at recommended doses are likely to be low. When fluticasone …
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.