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Menaril8 mg
Tablet
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Medicine overview
Indications of Menaril 8 mg
Meniere's disease and Meniere-like syndromes are characterized by attacks of vertigotinnitus and/or progressive loss of hearingusually accompanied by nausea and vomiting.
Theropeutic Class
Drugs used in meniere's diseases
Pharmacology
Betahistine acts as both partial histamine H1-receptor agonist and histamine H3-receptor antagonist in neuronal tissue.
Absorption
It improves the microcirculation in the labyrinth, thus reducing endolymphatic pressure.
Dosage & Administration of Menaril 8 mg
The usual initial dose
Dosage:8 mg to 16 mg three time's daily taken preferably with meals
Maintenance dosage
Dosage:Up to 48 mg daily have been recommended
Notes:Betahistine is not recommended for use in children and adolescents below age 18 due to lack of data on safety and efficacy
| Condition | Dosage | Notes |
|---|---|---|
| The usual initial dose | 8 mg to 16 mg three time's daily taken preferably with meals | |
| Maintenance dosage | Up to 48 mg daily have been recommended | Betahistine is not recommended for use in children and adolescents below age 18 due to lack of data on safety and efficacy |
Dosage of Menaril 8 mg
The usual initial dose
Dosage:8 mg to 16 mg three times daily taken preferably with meals
Maintenance dose
Dosage:Up to 48 mg daily has been recommended
Notes:Betahistine is not recommended for use in children
| Condition | Dosage | Notes |
|---|---|---|
| The usual initial dose | 8 mg to 16 mg three times daily taken preferably with meals | |
| Maintenance dose | Up to 48 mg daily has been recommended | Betahistine is not recommended for use in children |
Interaction of Menaril 8 mg
There are no proven cases of hazardous interactions. Though an antagonism between Betahistine and antihistamines could be expected on a theoretical basis, no such interactions have been reported.
Contraindications
Betahistine is contraindicated in pheochromocytoma.
Side Effects of Menaril 8 mg
Betahistine is generally well tolerated and there is no known serious adverse effects. In some circumstances gastrointestinal disturbances, headache, rashes and pruritus have been reported.
Pregnancy & Lactation
Pregnancy: There is a very limited amount of data from the use of betahistine in pregnant women. Animal studies, though insufficient do not indicate direct or indirect harmful effects with respect to reproductive toxicity . As a precautionary measure, it is preferable to avoid the use of Betahistine during pregnancy. Lactation: There is insufficient information on the excretion of betahistine in human milk. Betahistine should not be used during breast-feeding.
Precautions & Warnings
Caution should be exercised in patients with bronchial asthma and peptic ulceration.
Overdose Effects of Menaril 8 mg
Symptoms: Nausea, somnolence, abdominal pain, convulsion, pulmonary or cardiac complications. Management: Supportive treatment.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Drugs used in meniere's diseases
Mode Of Action
The mechanism of action of betahistine is multifactorial. Meniere's disease is thought to result from a disruption of endolymphatic fluid homeostasis in the ear. Betahistine mainly acts as a histamine H1-receptor agonist. The stimulation of H1-receptors in the inner ear causes a vasodilatory effect leading to increased permeability of blood vessels and a reduction in endolymphatic pressure; this action prevents the rupture of the labyrinth, which can contribute to the hearing loss associated with Ménière's disease. Betahistine is also purported to act by reducing the asymmetrical functioning of sensory vestibular organs and increasing vestibulocochlear blood flow, relieving symptoms of vertigo.In addition to the above mechanisms, betahistine also acts as a histamine H3-receptor antagonist, increasing the turnover of histamine from postsynaptic histaminergic nerve receptors, subsequently leading to an increase in H1-agonist activity. H3-receptor antagonism elevates levels of neurotransmitters including serotonin in the brainstem, inhibiting the activity of vestibular nuclei, thus restoring proper balance and decreasing vertigo symptoms.
Pregnancy
In Pregnancy: The safety of Betahistine in human pregnancy has not been completely established, although there is no known teratogenic effect in animals. A careful assessment of potential benefits should be made before prescribing Betahistine in pregnancy.In Lactation: Betahistine is excreted in the breast milk of nursing mothers in concentrations similar to those found in plasma. Toxicity to the neonate at these concentrations is not known.
Frequently Asked Questions
What is Menaril 8 mg used for?
Meniere's disease and Meniere-like syndromes are characterized by attacks of vertigo, tinnitus and/or progressive loss of hearing, usually accompanied by nausea and vomiting.
What is the dosage of Menaril 8 mg?
The usual initial dose: 8 mg to 16 mg three times daily taken preferably with meals.Maintenance dose: Up to 48 mg daily has been recommended. Betahistine is not recommended for use in children.
What are the side effects of Menaril 8 mg?
Betahistine is generally well tolerated and there is no known serious adverse effects. In some circumstances gastrointestinal disturbances, headache, rashes and pruritus have been reported.
Who should not take Menaril 8 mg?
Betahistine is contraindicated in pheochromocytoma.
What precautions should be taken with Menaril 8 mg?
Caution should be exercised in patients with bronchial asthma and peptic ulceration.
Is Menaril 8 mg safe during pregnancy and breastfeeding?
Pregnancy: There is a very limited amount of data from the use of betahistine in pregnant women. Animal studies, though insufficient do not indicate direct or indirect harmful effects with respect to reproductive toxicity . As a precautionary measure, it is preferable to avoid the use of Betahistine during pregnancy. Lactation: There is insufficient information on the excretion of betahistine in h…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.