Onsat8 mg
Oral Soluble Film
Medicine overview
Indications of Onsat 8 mg
Theropeutic Class
Pharmacology
Ondansetron is a selective 5-HT3 receptor antagonist.
However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine.
Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema.
It is not certain whether ondansetron's antiemetic action is mediated centrally, peripherally, or in both sites.
Dosage of Onsat 8 mg
| Condition | Dosage | Notes |
|---|---|---|
| The adult oral dosage is 24 mg given successively as three 8 mg films 30 minutes before the start of chemotherapy. Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy:Adults and pediatric patients 12 years of age and older: One 8 mg film 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later. Administer one 8 mg film twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy | ||
| Pediatric patients 4 through 11 years of age | One 4 mg film three times a day | Administer the first dose 30 minutes before chemotherapy, with subsequent doses 4 and 8 hours later. Administer one 4 mg film three times a day (every 8 hours) for 1 to 2 days after completion of chemotherapy. Prevention of nausea and vomiting associated with radiotherapy: The adult dosage is one 8 mg film three times a day |
| Postoperative nausea and vomiting | The adult dose is 16 mg given successively as two 8 mg films 1 hour before anesthesia |
Administration of Onsat 8 mg
Interaction of Onsat 8 mg
Contraindications
Side Effects of Onsat 8 mg
Precautions & Warnings
Storage Conditions
Use In Special Populations
Frequently Asked Questions
What is Onsat 8 mg used for?
Ondansetron is a 5-HT3 receptor antagonist indicated for: Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. Prevention of nausea and vomiting associated with radiotherapy in patients receiving total body irradiation, single high-dose frac…
What is the dosage of Onsat 8 mg?
The adult oral dosage is 24 mg given successively as three 8 mg films 30 minutes before the start of chemotherapy. Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy:Adults and pediatric patients 12 years of age and older: One 8 mg film 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later. Administer one 8 mg film twice a day (every 12 hour…
What are the side effects of Onsat 8 mg?
Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.The use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting
Who should not take Onsat 8 mg?
Concomitant use of apomorphine. Hypersensitivity to ondansetron.
What precautions should be taken with Onsat 8 mg?
Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.The use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting
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