10% Off
Onsat4 mg
Beximco Pharmaceuticals Ltd.
৳10.81
Add to cart
Generic medicine
Ondansetron [Oral Soluble Film]: Brands, Price & Uses in Bangladesh
Ondansetron [Oral Soluble Film] is a selective 5-HT3 (serotonin) receptor antagonist antiemetic delivered as a fast-dissolving oral strip.
About Ondansetron [Oral Soluble Film]
Indications of Ondansetron [Oral Soluble Film]
Ondansetron [Oral Soluble Film] is a selective 5-HT3 (serotonin) receptor antagonist antiemetic delivered as a fast-dissolving oral strip. Its established and evidence-supported uses include:
- Chemotherapy-induced nausea and vomiting (CINV): FDA-approved for prevention of nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin regimens.
- Radiotherapy-induced nausea and vomiting: FDA-approved for prevention of nausea and vomiting associated with radiotherapy, including total body irradiation, single high-dose fractions to the abdomen, and daily fractions to the abdomen.
- Postoperative nausea and vomiting (PONV): Approved for prevention of nausea and/or vomiting in adults undergoing surgery/anesthesia.
- Off-label use: Ondansetron [Oral Soluble Film] is commonly used off-label for acute gastroenteritis-associated vomiting in children (supported by pediatric emergency medicine practice, though not an FDA-labeled indication for this film formulation) and for nausea/vomiting of hyperemesis gravidarum, generally as a second-line option after other agents have been tried, under physician guidance.
Dosage & Administration of Ondansetron [Oral Soluble Film]
Chemotherapy-Induced Nausea and Vomiting
| Population | Dose of Ondansetron [Oral Soluble Film] |
|---|---|
| Adults and children ≥12 years (highly emetogenic chemotherapy) | 24 mg once, 30 minutes before start of chemotherapy |
| Adults and children ≥12 years (moderately emetogenic chemotherapy) | 8 mg 30 minutes before chemotherapy, repeated 8 hours later, then 8 mg every 12 hours for 1-2 days after completion of chemotherapy |
| Children 4-11 years | 4 mg three times daily; first dose 30 minutes before chemotherapy, then repeated at 4 and 8 hours after the first dose, continuing every 8 hours for 1-2 days after chemotherapy completion |
Radiotherapy-Induced Nausea and Vomiting
8 mg of Ondansetron [Oral Soluble Film] three times daily, with the first dose given 1-2 hours before radiotherapy.
Postoperative Nausea and Vomiting (Adults)
16 mg of Ondansetron [Oral Soluble Film] given as a single dose approximately 1 hour before induction of anesthesia.
Administration Technique
Using clean, dry hands, peel open the foil pouch and gently remove the film. Place the entire film on top of the tongue; it will dissolve within seconds. The dissolved film may be swallowed with saliva. Do not attempt to chew, swallow whole, or split the film. No water is required, and the film can be taken with or without food.
Side Effects of Ondansetron [Oral Soluble Film]
The most commonly reported side effects of Ondansetron [Oral Soluble Film] include:
- Headache (very common)
- Constipation (very common)
- Diarrhea
- Fatigue or malaise
- Dizziness
- Fever, particularly in pediatric patients receiving chemotherapy
- Transient elevations in liver enzymes
Less common but serious effects include dose-dependent QT interval prolongation (see Precautions and Warnings), hypersensitivity reactions including bronchospasm and anaphylaxis, and serotonin syndrome when combined with other serotonergic drugs.
Contraindications of Ondansetron [Oral Soluble Film]
Ondansetron [Oral Soluble Film] is contraindicated in the following situations:
- Known hypersensitivity to ondansetron or any component of the film formulation.
- Concomitant use with apomorphine, due to reports of profound hypotension and loss of consciousness with this combination.
- Patients with congenital long QT syndrome, due to increased risk of life-threatening ventricular arrhythmias (e.g., torsades de pointes).
Frequently Asked Questions about Ondansetron [Oral Soluble Film]
What is Ondansetron [Oral Soluble Film] used for?
Ondansetron [Oral Soluble Film] is used to prevent and treat nausea and vomiting caused by cancer chemotherapy, radiotherapy, and surgery/anesthesia. It is sometimes used off-label for severe vomiting from gastroenteritis or pregnancy-related nausea under a doctor's guidance.
How do I take Ondansetron [Oral Soluble Film]?
Peel open the pouch with dry hands, place the film on top of your tongue, and let it dissolve completely without chewing, swallowing whole, or cutting it. No water is needed, and it can be taken with or without food.
Can Ondansetron [Oral Soluble Film] affect my heart?
Yes. Ondansetron [Oral Soluble Film] can cause dose-dependent prolongation of the QT interval, which in rare cases can lead to a serious irregular heartbeat. Tell your doctor if you have heart disease, low potassium or magnesium levels, or are taking other medicines that affect heart rhythm.
Is Ondansetron [Oral Soluble Film] safe during pregnancy?
Ondansetron [Oral Soluble Film] should only be used in pregnancy if clearly needed and if your doctor decides the benefit outweighs the potential risk, since some studies have suggested a possible small risk to the fetus with early pregnancy use. Always consult your physician before use.
What are the common side effects of Ondansetron [Oral Soluble Film]?
The most common side effects are headache, constipation, diarrhea, tiredness, and dizziness. Serious but rare effects include allergic reactions, serotonin syndrome (with certain other medicines), and heart rhythm changes.
Who should not use Ondansetron [Oral Soluble Film]?
People with a known allergy to ondansetron, those taking apomorphine, and those with congenital long QT syndrome should not use Ondansetron [Oral Soluble Film]. Discuss your full medical history with your doctor before starting treatment.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.