Peranel2 mg

Peranel 2 mg an anti-epileptic drug is indicated for: Treatment of partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy from 4 years of age and older. Adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in patients with epilepsy from 12 years of age and older.

Peranel 2 mg can be taken without regard to food. The dosage of Peranel 2 mg is as follows- Starting dose: 2 mg once daily at bedtime. May increase dose based on clinical response and tolerability by increments of 2 mg once daily no more frequently than at weekly intervals. Recommended maintenance dose in monotherapy or adjunctive therapy for partial-onset seizures: 8 mg to 12 mg once daily at bedtime. Recommended maintenance dose in adjunctive therapy for primary generalized tonic-clonic seizures: 8 mg once daily at bedtime. Mild and Moderate Hepatic Impairment: Maximum recommended daily dose is 6 mg (mild) and 4 mg (moderate) once daily at bedtime. Severe Hepatic Impairment: Not recommended. Severe Renal Impairment: Not recommended.Elderly: Increase dose no more frequently than every 2 weeks.

Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel. Moderate and Strong CYP3A4 Inducers (including carbamazepine, oxcarbazepine, and phenytoin): increase the clearance of Peranel 2 mg and decrease Peranel 2 mg plasma concentrations.

None.

Peranel 2 mg may cause Serious Psychiatric and Behavioral Reactions, Suicidal Behavior and Ideation, Dizziness, Somnolence, Fatigue, Irritability, Falls, Nausea, Ataxia, Balance Disorder etc.

Suicidal Behavior and Ideation: Monitor for suicidal thoughts or Behaviour. Neurologic Effects: Monitor for dizziness, gait disturbance, somnolence and fatigue. Falls: Monitor for falls and injuries. Drug Reaction with Eosinophilia and Systemic Symptoms/Multi-organ Hypersensitivity: Discontinue if no alternate etiology. Withdrawal of Antiepileptic Drugs: In patients with epilepsy, there may be an increase in seizure frequency.

Protect from light and moisture, store below 30°C. Keep out of the reach of children.

Adjunct anti-epileptic drugs

Peranel 2 mg is a non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. Glutamate is the primary excitatory neurotransmitter in the central nervous system and is implicated in a number of neurological disorders caused by neuronal over excitation. The precise mechanism by which Peranel 2 mg exerts its antiepileptic effects in humans is unknown.

Based on animal data, may cause fetal harm. There are no data on the presence of Peranel 2 mg in human milk, the effects on the breastfed child, or the effects of the drug on milk production.