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Barbit60 mg
Incepta Pharmaceuticals Ltd.
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Phenoba60 mg
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Medicine overview
Indications of Phenoba 60 mg
in the emergency control of certain acute convulsive episodes(those associated with status epilepticuseclampsia meningitistetanusand toxic reactions to Strychnine or local anesthetics).
Theropeutic Class
Adjunct anti-epileptic drugs, Barbiturates
Pharmacology
Phenoba 60 mg is a long-acting barbiturate.
Absorption
It depresses the sensory cortex, reduces motor activity, changes cerebellar function and produces drowsiness, sedation and hypnosis. Its anticonvulsant property is exhibited at high doses.
Distribution
Phenoba 60 mg acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus.
Metabolism
Phenoba 60 mg may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of Phenoba 60 mg are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Dosage of Phenoba 60 mg
Notes:Suggested doses of Phenoba 60 mg for specific indications are as follows:Pediatric Oral Dosage: Preoperative: 1 mg to 3 mg/kg
Anticonvulsant
Dosage:1 mg to 6 mg/kg per day Adult Oral Dosage: Daytime sedative: 30 mg to 120 mg daily in 2 to 3 divided doses
Bedtime hypnotic
Dosage:100 mg to 320 mg
Anticonvulsant
Dosage:50 mg to 100 mg 2 to 3 times daily
Pediatric Injection Dosage
Dosage:15 to 20 mg/kg IV over 10 to 15 min
Preoperative Sedation
Dosage:1 to 3 mg/kg IM/IV; Anticonvulsant: 4 to 6 mg/kg IM/IV per day, for 10 days
Notes:Alternatively, use 10 to 15 mg/kg IM/IV per day to reach therapeutic level more quickly. Maxium IV rate 60 mg/min
Adult Injection Dosage
Dosage:Insomnia: 100 to 320 mg IM/IV; Convulsions: 100 to 320 mg IV
Notes:Repeat if needed (maximum, 600 mg per day); Status Epilepticus: 10 to 20 mg/kg IV. Repeat if needed
| Condition | Dosage | Notes |
|---|---|---|
| Suggested doses of Phenoba 60 mg for specific indications are as follows:Pediatric Oral Dosage: Preoperative: 1 mg to 3 mg/kg | ||
| Anticonvulsant | 1 mg to 6 mg/kg per day Adult Oral Dosage: Daytime sedative: 30 mg to 120 mg daily in 2 to 3 divided doses | |
| Bedtime hypnotic | 100 mg to 320 mg | |
| Anticonvulsant | 50 mg to 100 mg 2 to 3 times daily | |
| Pediatric Injection Dosage | 15 to 20 mg/kg IV over 10 to 15 min | |
| Preoperative Sedation | 1 to 3 mg/kg IM/IV; Anticonvulsant: 4 to 6 mg/kg IM/IV per day, for 10 days | Alternatively, use 10 to 15 mg/kg IM/IV per day to reach therapeutic level more quickly. Maxium IV rate 60 mg/min |
| Adult Injection Dosage | Insomnia: 100 to 320 mg IM/IV; Convulsions: 100 to 320 mg IV | Repeat if needed (maximum, 600 mg per day); Status Epilepticus: 10 to 20 mg/kg IV. Repeat if needed |
Administration of Phenoba 60 mg
May be taken with or without food.
Interaction of Phenoba 60 mg
The concomitant use of Alcohol or other CNS depressants may produce additive CNS depressant effects.
Contraindications
Phenoba 60 mg is contraindicated in patients with known Phenoba 60 mg sensitivity or a history of latent porphyria.
Side Effects of Phenoba 60 mg
The most common adverse reaction is somnolence. Other less frequent adverse reactions are agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, dizziness, thinking abnormality, apnea, bradycardia, hypotension, nausea, vomiting and constipation.
Pregnancy & Lactation
Pregnancy Category D. Phenoba 60 mg can cause potential fetal damage. Their use in pregnancy alone, or in combination with other anticonvulsants, can cause coagulation defects in the newborn infant which may be preventable by the prophylactic administration of Vitamin K to the mother prior to delivery. Phenoba 60 mg is excreted through human milk; so caution should be taken during lactation period.
Precautions & Warnings
Tolerance and psychological and physical dependence may occur with continuing use. Phenoba 60 mg should be administered with caution to patients who are mentally depressed, have suicidal tendencies, or a history of drug abuse. In patients with hepatic damage, Phenoba 60 mg should be administered with caution and initially reduced doses.
Overdose Effects of Phenoba 60 mg
The toxic dose of barbiturates varies considerably. In general, an oral dose of 1 gram of most barbiturates produces serious poisoning in an adult. Death commonly occurs after 2 to 10 grams of ingested barbiturate. Acute overdosage with barbiturates is manifested by CNS and respiratory depression Treatment of overdosage is mainly supportive and immediate hospitalization is necessary.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Reconstitution
Dilute with most IV infusion soln (e.g. NaCl 0.45% or 0.9%, lactated Ringer's, dextrose 5%, Ringer's).
Drug Classes
Adjunct anti-epileptic drugs, Barbiturates
Mode Of Action
Phenoba 60 mg, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Phenoba 60 mg acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenoba 60 mg may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of Phenoba 60 mg are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Pregnancy
Pregnancy Category D. Phenoba 60 mg can cause fetal damage when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be in risk of the potential hazard to the fetus. Caution should be taken when Phenoba 60 mg is administered to a nursing woman since small amounts of Phenoba 60 mg are excreted in the milk.
Frequently Asked Questions
What is Phenoba 60 mg used for?
Phenobarbital is indicated for the following conditions: Sedatives Hypnotics for the short-term treatment of insomnia Pre-anesthetics Long-term anticonvulsants for the treatment of generalized tonic-clonic and cortical local seizures. And, in the emergency control of certain acute convulsive episodes, (those associated with status epilepticus, eclampsia meningitis, tetanus, and toxic reactions to …
What is the dosage of Phenoba 60 mg?
Suggested doses of Phenobarbital for specific indications are as follows:Pediatric Oral Dosage: Preoperative: 1 mg to 3 mg/kg. Anticonvulsant: 1 mg to 6 mg/kg per day Adult Oral Dosage: Daytime sedative: 30 mg to 120 mg daily in 2 to 3 divided doses. Bedtime hypnotic: 100 mg to 320 mg. Anticonvulsant: 50 mg to 100 mg 2 to 3 times daily. Pediatric Injection Dosage: 15 to 20 mg/kg IV over 10 to 15 m…
What are the side effects of Phenoba 60 mg?
The most common adverse reaction is somnolence. Other less frequent adverse reactions are agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, dizziness, thinking abnormality, apnea, bradycardia, hypotension, nausea, vomiting and constipation.
Who should not take Phenoba 60 mg?
Phenobarbital is contraindicated in patients with known Phenobarbital sensitivity or a history of latent porphyria.
What precautions should be taken with Phenoba 60 mg?
Tolerance and psychological and physical dependence may occur with continuing use. Phenobarbital should be administered with caution to patients who are mentally depressed, have suicidal tendencies, or a history of drug abuse. In patients with hepatic damage, Phenobarbital should be administered with caution and initially reduced doses.
Is Phenoba 60 mg safe during pregnancy and breastfeeding?
Pregnancy Category D. Phenobarbital can cause potential fetal damage. Their use in pregnancy alone, or in combination with other anticonvulsants, can cause coagulation defects in the newborn infant which may be preventable by the prophylactic administration of Vitamin K to the mother prior to delivery. Phenobarbital is excreted through human milk; so caution should be taken during lactation period…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.