Pronil500 mg

Pronil 500 mg is indicated in- Intestinal Amoebiasis Hepatic Amoebiasis Urethritis and vaginitis due to Trichomonas vaginalis Giardiasis

Amoebicides, Anti-diarrhoeal Antiprotozoal

Pronil 500 mg is the first nitroimidazole to offer a 3 day antiprotozoal activity from one single dose. With its prolonged half life, Pronil 500 mg offers an effective treatment and thus ensures improved patient compliance because of the short duration of treatment with excellent therapeutic efficacy.Pronil 500 mg exhibits activity against anaerobic protozoa Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Pronil 500 mg is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Pronil 500 mg.The plasma elimination half life is about 20 hours. The majority of Pronil 500 mg is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Pronil 500 mg gives it the longest half-life of all the second generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.

Pronil 500 mg tablet should be administered orally. The dosage schedule of Pronil 500 mg tablet is mentioned below: Pronil 500 mg Tablet: Amoebiasis:Acute intestinal amoebiasis: Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before meal. Children: 30 mg/kg single dose, taken preferably just before meal. Asymptomatic amoebiasis (minute & cystic form): Adults: 2 gm once daily (2x1000 mg tablet) for only 3 days, taken preferably just before meal. Children: 30 mg/kg once daily for only 3 days, taken preferably just before meal. Hepatic amoebiasis : Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days. Children: 30 mg/kg/day, in a single or divided dose, just before meal for 5 days. N.B.: Evacuation of pus must be performed simultaneously with Pronil 500 mg treatment at the suppurative stage of hepatic amoebiasis.Giardiasis : Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before meal. Children: 35-50 mg/kg single dose, taken preferably just before meal. Trichomoniasis : Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before meal. Children: 30 mg/kg single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly. Pronil 500 mg Suspension: Suspension should be administered orally. The dosage schedule of Pronil 500 mg suspension is mentioned below: Children of 10 to 15 kg body weight: 1 bottle of Pronil 500 mg 500 mg suspension. Children of 16 to 25 kg body weight: 1½ bottle of Pronil 500 mg 500 mg suspension. Children of 26 kg or more body weight: 2 bottles of Pronil 500 mg 500 mg suspension.

Pronil 500 mg tablet should be administered orally. The dosage schedule of is mentioned below:Acute Intestinal Amoebiasis: Adults: 2 gm single dose, taken preferably just before meal. Children: 30 mg/kg single dose, taken preferably just before meal. Asymptomatic Amoebiasis (minute& cystic form): Adults: 2 gm once daily for only 3 days, taken preferably just before meal. Children: 30 mg/kg once daily for only 3 days, taken preferably just before meal. Hepatic Amoebiasis: Evacuation of pus must be performed simultaneously with Pronil 500 mg treatment at the suppurative stage of hepatic amoebiasis. Adults: 1.50 gm/day in a single or divided doses, just before meal, for 5 days. Children: 30 mg/kg/day, in a single or divided dose, just before meal, for 5 days. Giardiasis: Adults: 2 gm single dose, taken preferably just before meal. Children: 35-50 mg/kg single dose, taken preferably just before meal. Trichomoniasis: Adults: 2 gm single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly.

Administration of Pronil 500 mg with disulfiram is not recommended: confusional state & paranoid reaction may occur. Use of Pronil 500 mg simultaneously with warfarin requires close monitoring: increased effect or oral anticoagulants and of the hemormagic risk is likely.

Pronil 500 mg is contra-indicated for those patients who are hypersensitive to imidazole derivatives.

The clinical studies have shown that Pronil 500 mg is characterized by very good tolerance and no serious adverse reactions have been reported to date. The following side-effects may be observed with Pronil 500 mg as with all nitroimidazole derivatives & are rarely serious: Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, stomatitis. Occasional side effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation. Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, peripheral neuropathy. With Pronil 500 mg, gastrointestinal disorders e.g. nausea, vomiting, eoigastric pain, etc., have been reported in very rare cases.

Pronil 500 mg may be prescribed in pregnancy after the first trimester. As with other similar drugs, Pronil 500 mg should not be administered during the first trimester of pregnancy or during lactation because Pronil 500 mg is found in placenta and breast milk.

Patients should be advised not to take alcohol during treatment with Pronil 500 mg (because of the possibility of antabuse effect). Administration of Pronil 500 mgshould be avoided to patients with a history of blood dyscrasia.

Store in a cool, dry place,protected from heat.

Amoebicides, Anti-diarrhoeal Antiprotozoal

Pronil 500 mg is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Pronil 500 mg. The plasma elimination half-life is about 20 hours. The majority of Pronil 500 mg is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Pronil 500 mg gives it the longest half-life of second-generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.

Pronil 500 mg may be prescribed in pregnancy after the first trimester. As with other similar drugs, Pronil 500 mg should not be administered during the first trimester of pregnancy or during lactation because Pronil 500 mgis found in the placenta and breast milk.