Saglit

Saglit15 mg

Tablet

Pioglitazone

Synovia Pharma PLC

Product Code : 15319
MRP 8.03
8% Off
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Medicine overview

Indications of Saglit 15 mg

Saglit 15 mg is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type II diabetes (NIDDM). Saglit 15 mg is indicated for monotherapy and also indicated for use in combination with sulphonylurea, Metformin or Insulin when diet and exercise plus the single agent does not result in adequate glycaemic control.

Theropeutic Class

Thiazolidinedione Group

Pharmacology

Saglit 15 mg is a preparation of Saglit 15 mg which is a member of the newest class of oral antidiabetic agent called thiazolidinediones. It depends on the presence of Insulin for its mechanism of action. Saglit 15 mg decreases Insulin resistance in the periphery and in the liver, resulting in increased Insulin dependent glucose disposal and decreased hepatic glucose output. It also improves abnormality in lipid metabolism by activating peroxisome proliferator activated receptor gamma (PPAR-γ).

Dosage & Administration of Saglit 15 mg

Saglit 15 mg can be taken once daily without regard to meals. The management of antidiabetic therapy should be individualized. Saglit 15 mg monotherapy may be initiated at 15 mg or 30 mg once daily dosages in patients not adequately controlled with diet and exercise alone. For patients who respond inadequately to the initial dose of Saglit 15 mg, the dose can be increased up to 45 mg once daily. For patients not responding adequately to monotherapy, combination therapy should be considered.Maximum recommended daily dose of Saglit 15 mg should not exceed 45 mg since doses higher than 45 mg have not been studied in placebo controlled clinical studies. Besides, no placebo controlled clinical studies of more than 30 mg once daily have been conducted in combination therapy.

Dosage of Saglit 15 mg

Saglit 15 mg can be taken once daily without regard to meals. The management of antidiabetic therapy should be individualized. Saglit 15 mg monotherapy may be initiated at 15 mg or 30 mg once daily dosages in patients not adequately controlled with diet and exercise alone. For patients who respond inadequately to the initial dose of Saglit 15 mg, the dose can be increased up to 45 mg once daily. For patients not responding adequately to monotherapy, combination therapy should be considered.Maximum recommended daily dose of Saglit 15 mg should not exceed 45 mg since doses higher than 45 mg have not been studied in placebo controlled clinical studies. Besides, no placebo controlled clinical studies of more than 30 mg once daily have been conducted in combination therapy.

Interaction of Saglit 15 mg

Administration of thiazolidinediones with an oral contraceptive containing ethinyl oestradiol and norethindrone reduces the plasma concentration of both hormones by approximately 30% which could result in loss of contraception.

Contraindications

Saglit 15 mg is contraindicated in patients with known hypersensitivity to any of its components.

Side Effects of Saglit 15 mg

The overall incidence and types of adverse events reported in placebo controlled clinical trials of Saglit 15 mg monotherapy at doses of 7.5 mg, 15 mg, 30 mg or 45 mg once daily are upper respiratory tract infection (13.2%), headache (9.1%), sinusitis (6.3%), myalgia (5.4%), tooth disorder (5.3%), and pharyngitis (5.1%).

Pregnancy & Lactation

Pregnancy: There are no adequate and well controlled studies in pregnant women. Saglit 15 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.Lactation: It is not known whether Saglit 15 mg is secreted in human milk. As many drugs are excreted in human milk, it should not be administered to a lactating women.

Precautions & Warnings

Saglit 15 mg exerts its antihyperglycaemic effect only in the presence of Insulin. Therefore, it should not be used in Type 1 diabetes or for the treatment of diabetic ketoacidosis. Saglit 15 mg should be used with caution in case of combination antidiabetic therapy and hepatic insufficiency. Liver enzyme should be monitored regularly.

Storage Conditions

Store at 25° C.

Drug Classes

Thiazolidinedione Group

Mode Of Action

Saglit 15 mg is a preparation of Saglit 15 mg which is a member of the newest class of oral antidiabetic agent called thiazolidinediones. It depends on the presence of Insulin for its mechanism of action. Saglit 15 mg decreases Insulin resistance in the periphery and in the liver, resulting in increased Insulin dependent glucose disposal and decreased hepatic glucose output. It also improves abnormality in lipid metabolism by activating peroxisome proliferator activated receptor gamma (PPAR-γ).

Pregnancy

Pregnancy: There are no adequate and well controlled studies in pregnant women. Saglit 15 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.Lactation: It is not known whether Saglit 15 mg is secreted in human milk. As many drugs are excreted in human milk, it should not be administered to a lactating women.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.