Servidoxyne100 mg

Servidoxyne 100 mg is a broad-spectrum tetracycline antibiotic indicated for a wide range of infections caused by susceptible microorganisms. It is prescribed when the causative bacteria are known or likely to respond to doxycycline, and it is often used as an alternative in patients who cannot tolerate penicillin.

Respiratory Tract Infections

• Pneumonia
• Influenza and associated secondary infections
• Sinusitis
• Bronchitis
• Tonsillitis
• Tracheitis

Gastrointestinal Tract Infections

• Cholera
• Traveller's diarrhoea
• Shigella dysentery
• Acute intestinal amoebiasis

Chlamydial Infections

• Lymphogranuloma venereum
• Psittacosis
• Trachoma

Sexually Transmitted Infections (STIs)

• Non-gonococcal urethritis
• Acute pelvic inflammatory disease
• Uncomplicated urethral, endocervical or rectal infections
• Gonorrhoea
• Syphilis
• Pyelonephritis and cystitis

Other Infections

• Impetigo and furunculosis
• Inclusion conjunctivitis
• Brucellosis
• Tularaemia
• Cellulitis
• Acne
• Q-fever

Always take this medicine as directed by a registered physician.

Doxycycline is a highly active, broad-spectrum antibiotic belonging to the tetracycline group. It is effective against a wide range of Gram-positive and Gram-negative bacteria, as well as spirochetes, mycoplasma, rickettsia and mycobacteria. Because of this broad coverage, doxycycline is frequently used as an alternative to penicillin in the treatment of gonorrhoea and syphilis.

The primary mechanism of action of doxycycline is the inhibition of bacterial protein synthesis. After entering the bacterial cell, it binds to the ribosome and blocks the production of essential proteins, thereby preventing the bacteria from multiplying and allowing the body's immune system to clear the infection.

Servidoxyne 100 mg belongs to the tetracycline group of antibiotics.

Servidoxyne 100 mg is a semisynthetic tetracycline antibiotic with broad-spectrum activity. It is primarily bacteriostatic, meaning it inhibits bacterial growth and reproduction rather than killing bacteria outright. It works by binding to the 30S ribosomal subunit of susceptible bacteria, blocking the attachment of aminoacyl-tRNA and halting protein synthesis.

Although its spectrum of activity is similar to other tetracyclines, doxycycline is notably more active against Staphylococcus aureus and Nocardia. It is frequently effective against penicillin-resistant strains of Staphylococcus aureus and against organisms that have developed resistance to older tetracyclines. Certain Gram-negative strains of E. coli, Proteus mirabilis and Klebsiella, which are often resistant to tetracycline, may still be sensitive to doxycycline.

Around 70–90% of common anaerobes are sensitive to doxycycline, and Bacteroides fragilis is more likely to respond to doxycycline than to other tetracyclines. Doxycycline is active against most strains of Haemophilus influenzae and is particularly useful against H. ducreyi, Actinomyces, Brucella and Vibrio cholerae. It also demonstrates activity against Nocardia, Chlamydia, Mycoplasma and a wide range of Rickettsiae.

In addition, doxycycline is effective against spirochetes such as Borrelia recurrentis, Treponema pallidum and Treponema pertenue, and it shows activity against Plasmodium falciparum, which underpins its role in malaria prophylaxis and treatment.

Servidoxyne 100 mg may interact with several medicines and substances, which can reduce its effectiveness or alter the action of other drugs:

• Absorption of tetracyclines is impaired by antacids containing aluminium, calcium or magnesium, and by iron-containing preparations.
• Bismuth salicylate can also reduce the absorption of tetracyclines.
• Barbiturates, carbamazepine and phenytoin can decrease the half-life of doxycycline, potentially lowering its blood levels.
• Concurrent use of tetracyclines may reduce the effectiveness of oral contraceptives.
• Patients on anticoagulant therapy may require a downward adjustment of their anticoagulant dose.
• It is advisable to avoid giving tetracyclines together with penicillin, as they may interfere with each other's action.

Inform your physician of all medicines, supplements and antacids you are taking before starting doxycycline.

Like all medicines, Servidoxyne 100 mg can cause side effects, although not everyone experiences them. Commonly reported side effects include:

• Nausea
• Vomiting
• Diarrhoea
• Skin rashes
• Haemolytic anaemia
• Eosinophilia

Most side effects are mild and temporary. If any reaction is severe, persistent, or if signs of an allergic reaction occur, stop taking the medicine and seek medical attention promptly.

Doxycycline should be avoided during pregnancy because of the risk of staining the developing teeth and affecting bone growth in the foetus. It is therefore not recommended for use in pregnant women.

Doxycycline passes into breast milk. Mothers who need to take this medicine should not breastfeed their child during treatment, as it may affect the infant's developing teeth and bones.

The use of tetracycline-class drugs during tooth development—covering the last half of pregnancy, infancy, and childhood up to 8 years of age—may cause permanent discoloration of the teeth. For this reason, doxycycline should not be used in this age group unless clearly necessary and directed by a physician.

Patients should take the medicine with plenty of fluid while upright to avoid oesophageal irritation. As doxycycline can increase sensitivity to sunlight, prolonged exposure to strong sunlight or UV light should be avoided during treatment. Complete the full prescribed course even if symptoms improve, to reduce the risk of antibiotic resistance.

In the event of an overdose, the risk of dose-related toxic effects, particularly on the gastrointestinal tract, may increase. There is no specific antidote for doxycycline. Treatment is supportive and symptomatic, and antacids or magnesium/calcium/iron salts may be given to reduce further absorption of the drug. If an overdose is suspected, contact a physician or the nearest emergency service immediately.

Store in a cool, dry place, protected from light. Keep all medicines out of the reach of children. Do not use the medicine after its expiry date.

Children

Doxycycline is contraindicated in children under 8 years of age due to the risk of permanent tooth discoloration and impaired bone growth.

Pregnant & Breastfeeding Women

The medicine should be avoided during pregnancy and lactation because it can affect the developing teeth and bones of the foetus or infant.

Elderly Patients

No specific dose adjustment is generally required for elderly patients; however, they should be monitored for gastrointestinal and other side effects, especially during longer courses of treatment.

Renal & Hepatic Impairment

Doxycycline is generally preferred over other tetracyclines in patients with reduced kidney function, but it should still be used with caution and under medical supervision in patients with liver or kidney impairment.

Tetracycline group of drugs

Servidoxyne 100 mg is a semisynthetic tetracycline antibiotic with broad spectrum activity. It is primarily a bacteriostatic antibiotic. It has a similar spectrum of activity to other tetracyclines but in particular is more active against Staphylococcus aureus and Nocardia. The drug is often active against penicillin-resistant strains of Staphylococcus aureus and against strains of those organisms that are resistant to other Tetracyclines. Certain Gram-negative strains of E. coli, Proteus mirabilis and Klebsiella, which are often resistant to Tetracycline, may be sensitive to Doxycycline. In addition, 70-90% of the various anaerobes are sensitive to Doxycycline and Bacteroides fragilis is more likely to be sensitive to Doxycycline than to other tetracyclines.Doxycycline is active against most strains of Haemophilus influenzaeand is particularly useful for infections with H. ducreyi, Actinomyces, Brucella and Vibrio cholerae. It is also active against Nocardia, Chlamydia, Mycoplasma and a wide range of Rickettsiae. Doxycycline is active against spirochetes such as Borellia recurrentis, Treponema pallidum and Treponema pertenue. It is also active against Plasmodium falciparum.

Doxycycline should be avoided in pregnant women, because of the risk of both staining and effect on bone growth in the foetus. Doxycyclines enter breast milk, and mothers taking these drugs should not breastfeed their child.