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Spusoft300 mg
Capsule
Erdosteine
Incepta Pharmaceuticals Ltd.
Product Code : 20791
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Medicine overview
Indications of Spusoft 300 mg
Spusoft 300 mg is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.
Theropeutic Class
Cough expectorants & mucolytics
Pharmacology
Spusoft 300 mg is a prodrug that is metabolised into N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.
Dosage & Administration of Spusoft 300 mg
The usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Spusoft 300 mg can be given up to 12 months or as directed by the physician. Spusoft 300 mg capsule may be taken with or without food.
Dosage of Spusoft 300 mg
The usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Spusoft 300 mg can be given up to 12 months or as directed by the physician. Spusoft 300 mg capsule may be taken with or without food.
Contraindications
It is contraindicated to patients who have hypersensitivity to Spusoft 300 mg. It should not be used in patients with creatinine clearance <25 ml/min, or with severe liver failure.
Side Effects of Spusoft 300 mg
Common side effect is epigastric pain. Other side effects include headache, cold, taste alterations, nausea, vomiting, diarrhea, angioedema and other skin allergic reactions.
Pregnancy & Lactation
The use of Spusoft 300 mg in pregnant or breast-feeding women is not recommended.
Precautions & Warnings
It should be used with caution in mild liver failure. In that case, should not exceed a dose of 300 mg per day.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of reach of children
Use In Special Populations
Renal Impairment: CrCl <25 ml/min: Contraindicated.Hepatic Impairment:
Mild to moderate: Max: 300 mg daily.
Severe: Contraindicated.
Drug Classes
Cough expectorants & mucolytics
Mode Of Action
Spusoft 300 mg is a prodrug that is metabolised into N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.
Pregnancy
The use of Spusoft 300 mg in pregnant or breast-feeding women is not recommended.
Pediatric Uses
Renal Impairment: CrCl <25 ml/min: Contraindicated.Hepatic Impairment:
Mild to moderate: Max: 300 mg daily.
Severe: Contraindicated.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
