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Promethazine Theoclate: Brands, Price & Uses in Bangladesh
Promethazine Theoclate is a phenothiazine-derivative antihistamine used mainly for its antiemetic and antivertigo effects.
About Promethazine Theoclate
Indications of Promethazine Theoclate
Promethazine Theoclate is a phenothiazine-derivative antihistamine used mainly for its antiemetic and antivertigo effects.
- Established/guideline-supported uses: Prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness (travel sickness).
- Established use: Symptomatic relief of nausea, vomiting, and vertigo arising from vestibular disorders, including Meniere's disease.
- Established use: Prevention and treatment of post-operative nausea and vomiting, as an adjunct to standard perioperative care.
Promethazine Theoclate is not indicated for the treatment of nausea and vomiting due to unrelated causes (e.g., chemotherapy-induced vomiting) where other agents are preferred.
Dosage & Administration of Promethazine Theoclate
Dosage of Promethazine Theoclate should be individualized by indication and age. General guidance is summarized below; a physician's advice should be followed for the exact regimen.
| Indication | Adult dose | Pediatric dose |
|---|---|---|
| Prevention of motion sickness (long journey) | 25 mg at bedtime the night before travel | Age 5–10 years: half the adult dose; age ≥10 years: adult dose; under 2 years: contraindicated (see Contraindications) |
| Prevention of motion sickness (short journey) | 25 mg taken 1–2 hours before travel | As above, age-adjusted |
| Treatment of motion sickness once symptoms start | 25 mg immediately, repeated that evening, then once more the following evening if needed | As above, age-adjusted |
| Nausea, vomiting, vertigo (e.g., Meniere's disease) | 25 mg at night; some patients may require 25 mg two to three times daily | As above, age-adjusted; use lowest effective dose |
See Dosage for a concise dose summary and Administration for how to take Promethazine Theoclate. See Pediatric Uses and Contraindications regarding use in young children.
Side Effects of Promethazine Theoclate
The most common side effects of Promethazine Theoclate relate to its sedating and anticholinergic properties.
- Common: Drowsiness, sedation, dizziness, headache, and psychomotor impairment.
- Anticholinergic effects: Dry mouth, blurred vision, urinary retention, and constipation.
- Less common: Restlessness or paradoxical excitation (particularly in children), nightmares, and photosensitivity skin reactions.
- Rare but serious: Severe respiratory depression (especially in young children – see Contraindications), extrapyramidal reactions, blood dyscrasias, jaundice, and hypersensitivity reactions including anaphylaxis.
Contraindications of Promethazine Theoclate
Promethazine Theoclate is contraindicated in the following situations:
- Known hypersensitivity to Promethazine Theoclate, promethazine, or other phenothiazines.
- Children under 2 years of age, due to the risk of severe, potentially fatal respiratory depression.
- Comatose states or significant CNS depression from other causes.
- Concurrent use with, or use within 14 days of, monoamine oxidase inhibitor (MAOI) therapy.
Frequently Asked Questions about Promethazine Theoclate
What is Promethazine Theoclate used for?
Promethazine Theoclate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness, as well as vertigo from inner-ear (vestibular) disorders such as Meniere's disease, and it is also used for post-operative nausea and vomiting.
Can I give Promethazine Theoclate to my child?
Promethazine Theoclate must never be given to children under 2 years of age because of a risk of severe, potentially fatal breathing difficulty. Children aged 5 to 10 years are usually given half the adult dose, and children 10 years and older may take the adult dose, but only on a doctor's advice.
Will Promethazine Theoclate make me drowsy?
Yes, drowsiness and dizziness are common with Promethazine Theoclate. You should avoid driving or operating machinery until you know how it affects you, and you should avoid alcohol while taking Promethazine Theoclate.
Is Promethazine Theoclate safe during pregnancy?
Promethazine Theoclate should be used in pregnancy only if a physician decides it is clearly needed, since the potential benefit must be weighed against potential risk to the fetus; it should generally be avoided close to delivery because of a risk of irritability in the newborn.
When should I take Promethazine Theoclate for travel sickness?
For long journeys, one 25 mg tablet of Promethazine Theoclate is usually taken at bedtime the night before travel; for shorter journeys, it is taken 1–2 hours before travel. Always follow your physician's or pharmacist's specific instructions.
What should I do if someone takes too much Promethazine Theoclate?
An overdose of Promethazine Theoclate is a medical emergency. Seek immediate medical attention or contact emergency services or a poison control center right away rather than attempting to treat it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.