Indications of Adair 500 mcg
Adair 500 mcg is indicated:
As add-on therapy to bronchodilator treatment.
For the maintenance treatment of severe Chronic Obstructive Pulmonary Disease (COPD) associated with chronic bronchitis (i.e. patients with a history of chronic cough and sputum) in adult patients with a history of frequent exacerbations.
Adair 500 mcg should not be used as a rescue medication.
Theropeutic Class
Antihistamines anti-allergies & hypo-sensitisation
Pharmacology
Adair 500 mcg is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system. It is thought that the increased levels of intracellular cyclic AMP are responsible for the therapeutic actions of Adair 500 mcg.
Dosage & Administration of Adair 500 mcg
The recommended dosage for patients with COPD is one 500 mcg tablet daily, with or without food.
Dosage of Adair 500 mcg
The recommended dosage for patients with COPD is one 500 mcg tablet daily, with or without food.
Interaction of Adair 500 mcg
A major step in Adair 500 mcg metabolism is the N-oxidation of Adair 500 mcg to Adair 500 mcg N-oxide by CYP3A4 and CYP1A2. Therefore, the use of strong cytochrome P450 enzyme inducers (e.g. rifampicin, phenobarbital, carbamazepine, phenytoin) with Adair 500 mcg is not recommended. The co-administration of Adair 500 mcg with CYP3A4 inhibitors or dual inhibitors that inhibit both CYP3A4 and CYP1A2 simultaneously (e.g., erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) may increase Adair 500 mcg systemic exposure and may result in increased adverse reactions. The co-administration of Adair 500 mcg with oral contraceptives containing gestodene and ethinyl estradiol may increase Adair 500 mcg systemic exposure and may result in increased side effects.
Contraindications
Hypersensitivity to Adair 500 mcg or to any of the excipients. Moderate to severe liver impairment.
Side Effects of Adair 500 mcg
General disorders: Fatigue.Metabolism and nutrition disorders: Decreased appetite, Weight decreased.Musculoskeletal and connective tissue disorders: Back pain, muscle spasms.Nervous system disorders: Dizziness, Headache, Tremor.Psychiatric disorders: Anxiety, Depression, Insomnia.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Adair 500 mcg should not be used during pregnancy & lactation.
Precautions & Warnings
Not as emergency treatment for relief of acute brochospasm. Monitor body wt regularly. Severe immunological disease, severe acute infections, cancers (except basal cell carcinoma) or patients on immunosuppressants; CHF (NYHA grades III & IV). History of depression associated with suicidal ideation or behavior. Galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. Hepatic impairment. Pregnancy & lactation.
Overdose Effects of Adair 500 mcg
No case of overdose has been reported in clinical studies with Adair 500 mcg. However, during the Phase I studies of Adair 500 mcg, at an increased rate after a single oral dose of 2500 mcg and a single dose of 5000 mcg, The following symptoms were observed: headache, gastrointestinal disorders, dizziness, palpitations, lightheadedness, clamminess and arterial hypotension.Missed Dose: Patients should be advised that if they forget to take a tablet at the usual time, they should take the tablet as soon as they remember or continue on the next day with the next tablet at the usual time. Patients should not take a double dose to make up for a forgotten dose.
Storage Conditions
Store below 30° C, keep away from light, moisture. Keep out of the reach of children.
Use In Special Populations
Geriatrics ( 65 years of age): There were no overall differences in safety and effectiveness of Adair 500 mcg in the elderly compared to younger patients with COPD. Therefore, no dose adjustment is necessary.Pediatrics (<18 years of age): Safety and effectiveness of Adair 500 mcg in children and adolescents below 18 years of age have not been established.Hepatic Impairment: Adair 500 mcg is not recommended for use in patients with moderate or severe liver impairment.Renal impairment: No dosage adjustment is necessary for patients with renal impairment
Drug Classes
Antihistamines anti-allergies & hypo-sensitisation
Mode Of Action
Adair 500 mcg is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system. It is thought that the increased levels of intracellular cyclic AMP are responsible for the therapeutic actions of Adair 500 mcg.
Pregnancy
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Adair 500 mcg should not be used during pregnancy & lactation.
Pediatric Uses
Geriatrics ( 65 years of age): There were no overall differences in safety and effectiveness of Adair 500 mcg in the elderly compared to younger patients with COPD. Therefore, no dose adjustment is necessary.Pediatrics (<18 years of age): Safety and effectiveness of Adair 500 mcg in children and adolescents below 18 years of age have not been established.Hepatic Impairment: Adair 500 mcg is not recommended for use in patients with moderate or severe liver impairment.Renal impairment: No dosage adjustment is necessary for patients with renal impairment