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Cynomin-H

Cynomin-H1000 mcg/ml

IM Injection

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Medicine overview

Indications of Cynomin-H 1000 mcg/ml

ingestionor dermal exposure to various cyanide-containing compoundsingestionor dermal exposure to various cyanide-containing compoundsincluding smoke from closed-space fires. Sources of cyanide poisoning include hydrogen cyanide and its saltscyanogenic plantsaliphatic nitrilesrapidCynomin-H 1000 mcg/ml should be administered without delay.In some settingstraumanose or oropharynx Altered mental status Although hypotension is highly suggestive of cyanide poisoningthese drugs should not be administered concurrently in the same intravenous line.

Theropeutic Class

Antidote preparations, Drugs for Megaloblastic Anemia

Pharmacology

Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobaiamin that is renally excreted.

Dosage & Administration of Cynomin-H 1000 mcg/ml

Thirty mcg daily for 5 to 10 days followed by 100 to 200 mcg monthly injected intramuscularly. If the patient is critically ill, or has neurologic disease, an infectious disease or hyperthyroidism, considerably higher doses may be indicated. However, current data indicate that the optimum obtainable neurologic response may be expected with a dosage of vitamin B12 sufficient to produce good hematologic response. Children may be given a total of 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance.

Dosage of Cynomin-H 1000 mcg/ml

Thirty mcg daily for 5 to 10 days followed by 100 to 200 mcg monthly injected intramuscularly. If the patient is critically ill, or has neurologic disease, an infectious disease or hyperthyroidism, considerably higher doses may be indicated. However, current data indicate that the optimum obtainable neurologic response may be expected with a dosage of vitamin B12 sufficient to produce good hematologic response. Children may be given a total of 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance.

Interaction of Cynomin-H 1000 mcg/ml

history of interaction with ARI Sodium Iodide (II23) 1 -12 MBq (sodium iodide i-123) ARI Sodium Iodide (1123) 100-750 MBq (sodium iodide i-123) arsenic trioxide Chloracol (chloramphenicol) chloramphenicol Chloromycetin (chloramphenicol) Chloromycetin Sodium Succinate (chloramphenicol) Hicon (sodium iodide-i-131) lodotope (sodium iodide-i-131) sodium iodide i-123 sodium iodide-i-131 Trisenox (arsenic trioxide)

Contraindications

Hypersensitivity to any component of this medication.

Side Effects of Cynomin-H 1000 mcg/ml

Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis. A few patients may experience pain after injection of Cynomin-H 1000 mcg/ml.

Pregnancy & Lactation

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Precautions & Warnings

The validity of diagnostic vitamin B12 or folic acid blood assays could be compromised by medications, and this should be considered before relying on such tests for therapy.Vitamin B12 is not a substitute for folic acid and since it might improve folic acid deficient megaloblastic anemia, indiscriminate use of vitamin B12 could mask the true diagnosis.Hypokalemia and thrombocytosis could occur upon conversion of severe megaloblastic to normal erythropoiesis with B12 therapy. Therefore, serum potassium levels and the platelet count should be monitored carefully during therapy.Vitamin B12 deficiency may suppress the signs of polycythemia vera. Treatment with vitamin B12 may unmask this condition.

Storage Conditions

Should be stored in cool and dry place

Drug Classes

Antidote preparations, Drugs for Megaloblastic Anemia

Mode Of Action

Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobaiamin that is renally excreted.

Pregnancy

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Frequently Asked Questions

What is Cynomin-H 1000 mcg/ml used for?

Hydroxocobalamin is indicated for the treatment of known or suspected cyanide poisoning.Identifying Patients with Cyanide Poisoning: Cyanide poisoning may result from inhalation, ingestion, or dermal exposure to various cyanide-containing compounds, including smoke from ... Read moreHydroxocobalamin is indicated for the treatment of known or suspected cyanide poisoning.Identifying Patients with Cy…

What is the dosage of Cynomin-H 1000 mcg/ml?

Thirty mcg daily for 5 to 10 days followed by 100 to 200 mcg monthly injected intramuscularly. If the patient is critically ill, or has neurologic disease, an infectious disease or hyperthyroidism, considerably higher doses may be indicated. However, current data indicate that the optimum obtainable neurologic response may be expected with a dosage of vitamin B12 sufficient to produce good hematol…

What are the side effects of Cynomin-H 1000 mcg/ml?

Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis. A few patients may experience pain after injection of hydroxocobalamin.

Who should not take Cynomin-H 1000 mcg/ml?

Hypersensitivity to any component of this medication.

What precautions should be taken with Cynomin-H 1000 mcg/ml?

The validity of diagnostic vitamin B12 or folic acid blood assays could be compromised by medications, and this should be considered before relying on such tests for therapy.Vitamin B12 is not a substitute for folic acid and since it might improve folic acid deficient megaloblastic anemia, indiscriminate use of vitamin B12 could mask the true diagnosis.Hypokalemia and thrombocytosis could occur up…

Is Cynomin-H 1000 mcg/ml safe during pregnancy and breastfeeding?

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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