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Amlodipine Besilate + Telmisartan: Brands, Price & Uses in Bangladesh
Amlodipine Besilate + Telmisartan is a fixed-dose combination of a dihydropyridine calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (telmisartan) and more.
About Amlodipine Besilate + Telmisartan
Indications of Amlodipine Besilate + Telmisartan
Amlodipine Besilate + Telmisartan is a fixed-dose combination of a dihydropyridine calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (telmisartan), indicated for:
- Established/first-line use: Treatment of hypertension, used alone or as an add-on with other antihypertensive agents, in patients whose blood pressure is not adequately controlled on monotherapy with either component.
- Initial combination therapy: May be used as initial therapy in patients likely to need multiple drugs to reach their blood pressure goal, based on their baseline blood pressure and overall cardiovascular risk.
- Cardiovascular risk reduction (guideline-supported): By lowering blood pressure, Amlodipine Besilate + Telmisartan reduces the risk of fatal and non-fatal cardiovascular events such as stroke and myocardial infarction in appropriate patients.
Amlodipine Besilate + Telmisartan is not indicated as initial therapy in patients 75 years of age or older, or in patients with hepatic impairment; in these groups, the individual components should be titrated separately first.
Dosage & Administration of Amlodipine Besilate + Telmisartan
Adult Dosage
| Clinical Scenario | Recommended Dose |
|---|---|
| Usual starting dose | 40 mg telmisartan/5 mg amlodipine once daily |
| Patients needing greater blood pressure reduction | 80 mg telmisartan/5 mg amlodipine once daily |
| Dose titration (after ≥2 weeks if BP not controlled) | May increase up to a maximum of 80 mg/10 mg once daily |
| Maximum dose | 80 mg telmisartan/10 mg amlodipine once daily |
Special Situations
- Elderly (≥75 years): Amlodipine Besilate + Telmisartan is not recommended as initial therapy; the amlodipine component should be started at a lower dose (2.5 mg) and titrated slowly before combination therapy is considered.
- Hepatic impairment: Not recommended for initial therapy. If used, start with a low amlodipine dose (2.5 mg) and titrate slowly, since telmisartan clearance is reduced in hepatic insufficiency (see Precautions).
- Renal impairment: No dose adjustment is generally needed in mild-to-moderate renal impairment; titrate slowly and monitor renal function in severe impairment.
Administration
Amlodipine Besilate + Telmisartan may be taken with or without food, at approximately the same time each day. Swallow the tablet whole; do not remove it from the blister pack until immediately before use.
Most of the antihypertensive effect is seen within 2 weeks, with the maximal effect generally achieved by about 4 weeks of therapy.
Side Effects of Amlodipine Besilate + Telmisartan
Most patients tolerate Amlodipine Besilate + Telmisartan well. Reported adverse effects include:
Common
- Peripheral (ankle/leg) edema — a dose-related effect of the amlodipine component
- Dizziness
- Back pain
- Headache
- Fatigue
- Flushing
Less Common but Clinically Important
- Symptomatic hypotension, particularly after the first dose or a dose increase (see Precautions)
- Hyperkalemia (see Precautions)
- Worsening of renal function in susceptible patients
Rare/Serious
- Angioedema (swelling of the face, lips, tongue, or throat) — potentially life-threatening; seek emergency care immediately if it occurs
- Rhabdomyolysis (rare)
- Hepatic dysfunction, jaundice
- Gynecomastia
Report any persistent, severe, or unusual side effect to your physician.
Contraindications of Amlodipine Besilate + Telmisartan
Amlodipine Besilate + Telmisartan is contraindicated in:
- Patients with known hypersensitivity to telmisartan, amlodipine, other dihydropyridine calcium channel blockers, or any component of the formulation.
- Co-administration with aliskiren in patients with diabetes mellitus (dual renin-angiotensin system blockade).
- Pregnancy — see Pregnancy and Lactation section; drugs acting on the renin-angiotensin system can cause fetal injury and death when used in the second and third trimesters.
Frequently Asked Questions about Amlodipine Besilate + Telmisartan
What is Amlodipine Besilate + Telmisartan used for?
Amlodipine Besilate + Telmisartan is used to treat high blood pressure (hypertension), either alone or together with other blood pressure medicines. It combines two medicines that work in different ways to relax and widen blood vessels, lowering blood pressure more effectively than either medicine alone.
How should I take Amlodipine Besilate + Telmisartan?
Take Amlodipine Besilate + Telmisartan exactly as prescribed by your physician, usually once daily, with or without food, at the same time each day. Do not stop taking it or change your dose without consulting your doctor, even if you feel well, since high blood pressure often has no symptoms.
Can I take Amlodipine Besilate + Telmisartan during pregnancy?
No. Amlodipine Besilate + Telmisartan is contraindicated in pregnancy. It can cause serious injury or death to the developing baby, especially if used during the second or third trimester. If you become pregnant while taking Amlodipine Besilate + Telmisartan, stop the medicine and contact your physician immediately so you can be switched to a safer alternative.
What are the most common side effects of Amlodipine Besilate + Telmisartan?
The most common side effects are swelling of the ankles or legs (peripheral edema), dizziness, headache, back pain, and flushing. These are often mild, but you should tell your doctor if they are bothersome or persistent.
Are there any foods or medicines I should avoid while taking Amlodipine Besilate + Telmisartan?
Avoid potassium supplements or salt substitutes containing potassium unless directed by your physician, as Amlodipine Besilate + Telmisartan can raise blood potassium levels. Also tell your doctor about all medicines you take, especially other blood pressure medicines (particularly ACE inhibitors or aliskiren), NSAIDs/painkillers, lithium, digoxin, or simvastatin, since these can interact with Amlodipine Besilate + Telmisartan.
What should I do if I miss a dose or take too much Amlodipine Besilate + Telmisartan?
If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose — do not double up. If you or someone else has taken too much Amlodipine Besilate + Telmisartan and shows signs such as severe dizziness, fainting, or a very fast or slow heartbeat, seek immediate medical attention or contact emergency services/poison control right away.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.