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Amino Acid + D-Sorbitol + Electrolytes: Brands, Price & Uses in Bangladesh
Amino Acid + D-Sorbitol + Electrolytes is a parenteral (intravenous) nutrition solution used to supply amino acids, fluid, calories (via D-Sorbitol) and more.
About Amino Acid + D-Sorbitol + Electrolytes
Indications of Amino Acid + D-Sorbitol + Electrolytes
Amino Acid + D-Sorbitol + Electrolytes is a parenteral (intravenous) nutrition solution used to supply amino acids, fluid, calories (via D-Sorbitol), and electrolytes to patients who cannot meet their nutritional requirements through oral or enteral feeding.
Established/Guideline-Supported Uses
- Source of amino acids for protein synthesis in patients requiring total or partial parenteral nutrition, including peri-operative and post-operative patients unable to tolerate oral/enteral intake.
- Nutritional support in catabolic states such as major surgery, trauma, sepsis, burns, and prolonged critical illness, where protein and calorie requirements are increased.
- Nutritional support in patients with gastrointestinal dysfunction (e.g., short bowel syndrome, severe malabsorption, prolonged ileus, inflammatory bowel disease flares) preventing adequate enteral intake.
- Adjunctive nutritional support in patients with cancer, chronic renal insufficiency, or hepatic insufficiency who have inadequate protein/calorie intake, used alongside disease-specific management, under close specialist supervision.
Use Requiring Combination Therapy
Amino Acid + D-Sorbitol + Electrolytes is typically administered as part of a complete parenteral nutrition regimen that also includes an energy source (dextrose and/or lipid emulsion), vitamins, and trace elements, prescribed and adjusted by the treating physician/nutrition team based on individual metabolic needs.
Dosage & Administration of Amino Acid + D-Sorbitol + Electrolytes
Amino Acid + D-Sorbitol + Electrolytes must be prescribed and administered by a physician or trained healthcare professional, with the dose individualized according to the patient's metabolic status, nitrogen requirement, fluid tolerance, and clinical condition.
Dosing by Metabolic/Clinical State (Adults)
| Clinical State | Nitrogen Requirement |
|---|---|
| No or minor metabolic stress | 0.10-0.15 g nitrogen/kg/day |
| Moderate metabolic stress | 0.15-0.20 g nitrogen/kg/day |
| Severe catabolism/stress (e.g., major trauma, sepsis, extensive burns) | 0.20-0.25 g nitrogen/kg/day |
This typically corresponds to a total infusion volume of about 1000-2000 mL per day of the 5% solution, given at an infusion rate of approximately 1.4-2.8 mL/minute, adjusted to fluid and metabolic tolerance.
Pediatric Dosing
In children and infants requiring parenteral nutrition, doses of approximately 28-35 mL/kg body weight/day (5% solution) have been used, started at a low infusion rate and increased gradually while monitoring tolerance; exact requirements should be individualized by a pediatrician/neonatologist experienced in parenteral nutrition.
Renal/Hepatic Impairment
In patients with renal or hepatic insufficiency, the rate, volume, and amino acid load require careful individualization and closer metabolic monitoring; specialized renal- or hepatic-formulated amino acid solutions may be preferred in advanced disease - see also Contraindications and Precautions.
Side Effects of Amino Acid + D-Sorbitol + Electrolytes
Most adverse effects of Amino Acid + D-Sorbitol + Electrolytes are related to infusion rate or the underlying clinical condition rather than the amino acid content itself.
- Common: Nausea (uncommon at recommended rates, more frequent with rapid infusion), warmth/flushing, sweating.
- With rapid or excessive infusion: Vomiting, headache, chills, hyperglycemia, osmotic diuresis.
- Infusion-site reactions: Pain, phlebitis, or thrombophlebitis, particularly with peripheral vein administration or hypertonic concentrations.
- Metabolic/laboratory changes: Transient elevation of liver enzymes, electrolyte disturbances (hyperkalemia, hypophosphatemia), and hyperglycemia - see also Precautions and Warnings.
- Rare: Hypersensitivity reactions (rash, fever); hyperphenylalaninemia in preterm infants receiving prolonged therapy.
Report any signs of an allergic reaction, breathing difficulty, chest pain, or infusion-site swelling/pain to the healthcare team immediately.
Contraindications of Amino Acid + D-Sorbitol + Electrolytes
Amino Acid + D-Sorbitol + Electrolytes is contraindicated in patients with:
- Known hypersensitivity to any of the amino acids, D-Sorbitol, or other components of the specific product.
- Hereditary fructose intolerance - D-Sorbitol is metabolized via a pathway that generates fructose, and administration can precipitate severe, potentially fatal hypoglycemia and organ (hepatic/renal) injury in these patients.
- Inborn errors of amino acid metabolism.
- Severe, uncompensated hepatic failure/hepatic coma.
- Severe renal impairment/uremia where dialysis is not available.
- Hyperosmolar, non-ketotic diabetic coma or severe uncontrolled hyperglycemia.
- General contraindications to intravenous infusion therapy, such as unstable hemodynamic status/shock, severe uncorrected electrolyte disturbances (e.g., severe hyperkalemia), and overhydration or pulmonary edema.
Frequently Asked Questions about Amino Acid + D-Sorbitol + Electrolytes
What is Amino Acid + D-Sorbitol + Electrolytes used for?
Amino Acid + D-Sorbitol + Electrolytes is an intravenous nutrition solution used to supply amino acids (protein building blocks), calories from D-Sorbitol, and electrolytes to patients who cannot get adequate nutrition by mouth or through the gut, such as after major surgery, in critical illness, or with severe gastrointestinal dysfunction.
Can I give myself Amino Acid + D-Sorbitol + Electrolytes at home?
No. Amino Acid + D-Sorbitol + Electrolytes is a prescription-only intravenous infusion that must be administered by a physician or trained healthcare professional in a hospital or supervised clinical setting, using a controlled infusion rate - it is not for self-administration or rapid injection.
Who should not receive Amino Acid + D-Sorbitol + Electrolytes?
Amino Acid + D-Sorbitol + Electrolytes should not be given to patients with known hypersensitivity to its components, hereditary fructose intolerance (because of the D-Sorbitol content), inborn errors of amino acid metabolism, severe uncompensated liver failure, severe uremia without access to dialysis, hyperosmolar non-ketotic diabetic coma, or unstable hemodynamic status - see Contraindications for the full list.
What are the common side effects of Amino Acid + D-Sorbitol + Electrolytes?
With Amino Acid + D-Sorbitol + Electrolytes, nausea is uncommon at the recommended infusion rate, but rapid infusion can cause vomiting, flushing, sweating, headache, and infusion-site irritation (pain or phlebitis). Metabolic changes such as raised blood sugar, electrolyte shifts, and transient liver enzyme elevation can also occur, especially with high infusion rates - see Side Effects for details.
Is Amino Acid + D-Sorbitol + Electrolytes safe during pregnancy?
Amino Acid + D-Sorbitol + Electrolytes should be used in pregnancy only if clearly needed, when the physician judges that the nutritional benefit outweighs any potential risk, since well-controlled human studies are limited. Always consult a physician before use during pregnancy or breastfeeding.
What happens if the infusion of Amino Acid + D-Sorbitol + Electrolytes is given too fast?
Infusing Amino Acid + D-Sorbitol + Electrolytes too quickly can cause nausea, vomiting, sweating, thrombophlebitis, high blood sugar, and excessive fluid/electrolyte shifts. Because it is given under medical supervision, the healthcare team will slow or stop the infusion and manage any reaction; if a problem is suspected outside a monitored setting, seek immediate medical attention.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.