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Olmedip5 mg+40 mg
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Amlodipine + Olmesartan Medoxomil: Brands, Price & Uses in Bangladesh
Amlodipine + Olmesartan Medoxomil is a fixed-dose combination of a dihydropyridine calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (ARB, olmesartan medoxomil) and more.
About Amlodipine + Olmesartan Medoxomil
Indications of Amlodipine + Olmesartan Medoxomil
Amlodipine + Olmesartan Medoxomil is a fixed-dose combination of a dihydropyridine calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (ARB, olmesartan medoxomil), indicated for:
- Established/FDA-approved use: Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily stroke and myocardial infarction.
- Amlodipine + Olmesartan Medoxomil is generally used in patients whose blood pressure is not adequately controlled on either amlodipine or olmesartan monotherapy alone, or as initial therapy in patients likely to need multiple drugs to reach their blood pressure goal.
Amlodipine + Olmesartan Medoxomil is not indicated for initial therapy in patients who require blood pressure reduction of more than 20/10 mmHg without prior assessment, as recommended by treating physicians on a case-by-case basis, and is not intended as a first-line drug for hypertensive emergencies.
Dosage & Administration of Amlodipine + Olmesartan Medoxomil
General Dosing Principles
Amlodipine + Olmesartan Medoxomil is taken once daily, with or without food, and should be swallowed whole with water.
Adult Dosing for Hypertension
| Clinical Situation | Recommended Dose |
|---|---|
| Initial therapy in adults not at goal on monotherapy | 5 mg/20 mg once daily |
| Dose titration (if blood pressure not controlled after 1-2 weeks) | Increase to a maximum of 10 mg/40 mg once daily, at intervals of at least 2 weeks |
Elderly Patients (≥75 years)
Because of a greater sensitivity to amlodipine in patients ≥75 years, initiation of Amlodipine + Olmesartan Medoxomil as a starting combination product is generally not recommended in this age group; treatment should instead be titrated using the individual components under physician guidance.
Renal Impairment
No initial dosage adjustment of Amlodipine + Olmesartan Medoxomil is required in patients with moderate to marked renal impairment, but renal function and serum potassium should be monitored periodically.
Hepatic Impairment
Amlodipine + Olmesartan Medoxomil is generally not recommended as initial therapy in patients with hepatic impairment; if used, doses should be adjusted cautiously and the patient monitored closely, since amlodipine clearance is reduced in hepatic impairment.
Pediatric Dosing
Safety and efficacy of Amlodipine + Olmesartan Medoxomil in pediatric patients have not been established; it is not recommended for use in children.
Side Effects of Amlodipine + Olmesartan Medoxomil
The most common adverse effect reported with Amlodipine + Olmesartan Medoxomil is:
- Edema (peripheral swelling, dose-related, more common in women) — the most frequently reported adverse reaction.
- Headache
- Dizziness
- Flushing
- Fatigue
- Upper respiratory tract infection symptoms
Less common but clinically important adverse effects include:
- Hyperkalemia and changes in renal function — see Precautions and Warnings.
- Sprue-like enteropathy: rare cases of severe, chronic diarrhea with substantial weight loss, sometimes occurring months to years after starting olmesartan-containing products; usually resolves after discontinuation of Amlodipine + Olmesartan Medoxomil.
- Angioedema (swelling of face, lips, tongue, throat) — rare but potentially serious; discontinue Amlodipine + Olmesartan Medoxomil immediately if this occurs.
- Elevated liver enzymes and, rarely, rhabdomyolysis, have been reported post-marketing.
Contraindications of Amlodipine + Olmesartan Medoxomil
Amlodipine + Olmesartan Medoxomil is contraindicated in:
- Patients with known hypersensitivity to amlodipine, olmesartan medoxomil, or any component of Amlodipine + Olmesartan Medoxomil.
- Coadministration with aliskiren in patients with diabetes mellitus.
Frequently Asked Questions about Amlodipine + Olmesartan Medoxomil
What is Amlodipine + Olmesartan Medoxomil used for?
Amlodipine + Olmesartan Medoxomil is used to treat high blood pressure (hypertension), either in patients who are not adequately controlled on a single blood-pressure medicine, or as initial combination therapy in patients likely to need more than one drug to reach their blood pressure goal.
Can Amlodipine + Olmesartan Medoxomil be taken during pregnancy?
No. Amlodipine + Olmesartan Medoxomil is contraindicated in pregnancy. It can cause serious harm to the developing fetus, including kidney problems, low amniotic fluid, and other birth defects, especially if used in the second or third trimester. If pregnancy occurs or is suspected while taking Amlodipine + Olmesartan Medoxomil, stop the medicine and contact your physician immediately to switch to a safer alternative.
What are the most common side effects of Amlodipine + Olmesartan Medoxomil?
The most common side effect is swelling (edema) of the legs, ankles, or feet. Other common effects include headache, dizziness, flushing, and fatigue. Most of these are mild, but you should tell your doctor if they are bothersome or persistent.
Can I take Amlodipine + Olmesartan Medoxomil with ibuprofen or other NSAID painkillers?
Regular use of NSAIDs (like ibuprofen or naproxen) with Amlodipine + Olmesartan Medoxomil can reduce its blood-pressure-lowering effect and, particularly in older adults, dehydrated patients, or those with kidney problems, can increase the risk of kidney injury. Discuss any regular NSAID use with your physician.
What should I do if I miss a dose or take too much Amlodipine + Olmesartan Medoxomil?
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose — do not double up. If you or someone else has taken more Amlodipine + Olmesartan Medoxomil than prescribed, this can cause dangerously low blood pressure and a fast heart rate; seek immediate medical attention or contact a poison control center right away rather than trying to manage it at home.
Does Amlodipine + Olmesartan Medoxomil cause kidney problems?
Amlodipine + Olmesartan Medoxomil can affect kidney function, particularly in people with pre-existing kidney disease, narrowing of the arteries to the kidneys, heart failure, or dehydration. Your doctor will typically monitor your kidney function and blood potassium levels periodically while you are taking Amlodipine + Olmesartan Medoxomil.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.