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Amoxicillin + Clavulanic Acid: Brands, Price & Uses in Bangladesh
Amoxicillin + Clavulanic Acid is a combination antibiotic consisting of amoxicillin (an aminopenicillin) and clavulanic acid (a beta-lactamase inhibitor).
About Amoxicillin + Clavulanic Acid
Indications of Amoxicillin + Clavulanic Acid
Amoxicillin + Clavulanic Acid is a combination antibiotic consisting of amoxicillin (an aminopenicillin) and clavulanic acid (a beta-lactamase inhibitor). It is indicated for the treatment of infections caused by susceptible, including beta-lactamase-producing, strains of bacteria.
Established / FDA-approved uses
- Acute bacterial sinusitis
- Community-acquired pneumonia
- Acute otitis media (particularly in children)
- Lower respiratory tract infections, including exacerbations of chronic bronchitis
- Skin and soft tissue infections
- Urinary tract infections
- Bone and joint infections
Guideline-supported / commonly used indications
- Odontogenic (dental) infections, including as adjunct with dental treatment
- Animal and human bite wound prophylaxis and treatment
- Diabetic foot infections (typically as part of combination therapy in moderate-to-severe cases)
Amoxicillin + Clavulanic Acid is generally preferred over amoxicillin alone when infection with a beta-lactamase-producing organism (e.g., certain strains of H. influenzae, M. catarrhalis, or S. aureus) is suspected or confirmed.
Dosage & Administration of Amoxicillin + Clavulanic Acid
Dosage of Amoxicillin + Clavulanic Acid is expressed in terms of the amoxicillin component and should be individualized based on the severity of infection, the susceptibility of the causative organism, and patient age, weight, and renal function.
Adults and children weighing 40 kg or more
| Indication | Typical Dose | Duration |
|---|---|---|
| Mild to moderate infections (e.g., skin/soft tissue, UTI) | 500 mg/125 mg every 12 hours or 250 mg/125 mg every 8 hours | 7–10 days |
| Severe or lower respiratory tract infections, sinusitis, otitis media | 875 mg/125 mg every 12 hours or 500 mg/125 mg every 8 hours | 7–14 days |
Children under 40 kg
Dosed by weight based on the amoxicillin component, typically 20–45 mg/kg/day in divided doses every 8–12 hours, using an oral suspension formulation. Higher doses (up to approximately 90 mg/kg/day) may be used for otitis media or when resistant S. pneumoniae is suspected, per treating physician's judgment. See also Use in Special Populations.
Renal impairment
Dose or dosing interval should be reduced in patients with reduced creatinine clearance; Amoxicillin + Clavulanic Acid is generally avoided in severe renal impairment (creatinine clearance below 30 mL/min) unless dosing is adjusted under medical supervision.
Important
Take Amoxicillin + Clavulanic Acid exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice. Completing the full prescribed course, even if symptoms improve early, is important to prevent relapse and antibiotic resistance.
Side Effects of Amoxicillin + Clavulanic Acid
The most common side effects of Amoxicillin + Clavulanic Acid (occurring in more than 2% of patients) include:
- Diarrhea and loose stools
- Nausea and vomiting
- Vaginal candidiasis (yeast infection)
- Skin rash
Diarrhea occurs more frequently with Amoxicillin + Clavulanic Acid than with amoxicillin alone, due to the clavulanic acid component; taking doses with food can help reduce gastrointestinal upset.
Less common but serious effects include hepatotoxicity/cholestatic jaundice (see Precautions and Warnings), hypersensitivity reactions, and Clostridioides difficile-associated diarrhea. Seek prompt medical attention for severe or persistent symptoms.
Contraindications of Amoxicillin + Clavulanic Acid
Amoxicillin + Clavulanic Acid is contraindicated in patients with:
- Known hypersensitivity (e.g., anaphylaxis, Stevens-Johnson syndrome) to amoxicillin, clavulanic acid, any penicillin, or any other component of the formulation
- A prior history of cholestatic jaundice or hepatic dysfunction specifically associated with previous use of Amoxicillin + Clavulanic Acid
Frequently Asked Questions about Amoxicillin + Clavulanic Acid
What is Amoxicillin + Clavulanic Acid used for?
Amoxicillin + Clavulanic Acid is a combination antibiotic used to treat bacterial infections of the respiratory tract, ears, sinuses, urinary tract, skin, and soft tissue, particularly infections caused by bacteria that would otherwise be resistant to amoxicillin alone.
Can I stop taking Amoxicillin + Clavulanic Acid once I feel better?
No. You should take Amoxicillin + Clavulanic Acid exactly as prescribed by your physician and complete the full course, even if you feel better before finishing it. Do not stop, extend, skip doses, or share this medicine with others without medical advice, as incomplete treatment can lead to relapse or antibiotic resistance.
What are the common side effects of Amoxicillin + Clavulanic Acid?
The most common side effects of Amoxicillin + Clavulanic Acid are diarrhea, nausea, vomiting, and vaginal yeast infection. Diarrhea is more common with Amoxicillin + Clavulanic Acid than with amoxicillin alone; taking it with food can help reduce stomach upset.
Is Amoxicillin + Clavulanic Acid safe during pregnancy?
Amoxicillin + Clavulanic Acid should be used during pregnancy only if clearly needed and if the potential benefit justifies the potential risk to the fetus. Please consult your physician before taking Amoxicillin + Clavulanic Acid if you are pregnant or planning to become pregnant.
Can Amoxicillin + Clavulanic Acid affect the liver?
Yes. Amoxicillin + Clavulanic Acid carries a recognized, though uncommon, risk of liver problems (hepatotoxicity), including jaundice, which is more likely with longer courses of treatment and in older patients. Seek medical attention promptly if you notice yellowing of the skin or eyes, dark urine, or unexplained nausea while taking or after finishing Amoxicillin + Clavulanic Acid.
Who should not take Amoxicillin + Clavulanic Acid?
Amoxicillin + Clavulanic Acid should not be taken by anyone with a known allergy to penicillins or a previous history of liver problems (jaundice) caused specifically by Amoxicillin + Clavulanic Acid. Tell your doctor about any prior drug allergies before starting treatment.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.