Bisoprolol Fumarate + Amlodipine: Brands, Price & Uses in Bangladesh

Bisoprolol Fumarate + Amlodipine is a fixed-dose combination antihypertensive indicated for:

• Hypertension: Treatment of high blood pressure in adult patients whose blood pressure is not adequately controlled on monotherapy with either a beta-blocker or a calcium channel blocker alone, and in patients likely to need more than one drug to reach their blood pressure goal. Bisoprolol Fumarate + Amlodipine is not indicated for initial therapy of hypertension.
• Adjunct in chronic stable angina (where clinically appropriate): Because both the beta-blocker and calcium channel blocker components have anti-anginal activity, Bisoprolol Fumarate + Amlodipine may be used, under physician supervision, as part of the management of chronic stable angina in hypertensive patients who also have angina, when combination therapy with these two drug classes is already indicated.

Use of Bisoprolol Fumarate + Amlodipine should be individualized by a physician based on blood pressure response and tolerability of each component.

Adult Dose - Hypertension

The usual starting dose of Bisoprolol Fumarate + Amlodipine is one tablet of the lowest available strength taken once daily by mouth, with or without food. Dose may be titrated by the physician based on individual response, up to a maximum combined dose typically not exceeding bisoprolol 10 mg/amlodipine 10 mg daily.

Pediatric Dose

Safety and efficacy of Bisoprolol Fumarate + Amlodipine have not been established in children; it is not recommended for pediatric use.

Renal Impairment

No initial dose adjustment of the amlodipine component is generally required in renal impairment. The bisoprolol component requires caution and possible dose reduction in patients with significant renal impairment (creatinine clearance below 40 mL/min); a physician should individualize Bisoprolol Fumarate + Amlodipine dosing.

Hepatic Impairment

Amlodipine clearance is reduced in hepatic impairment, and bisoprolol should also be used cautiously. Bisoprolol Fumarate + Amlodipine should be initiated at the lowest strength in patients with hepatic impairment, under close medical supervision.

If a dose of Bisoprolol Fumarate + Amlodipine is missed, it should be taken as soon as remembered unless it is nearly time for the next dose, in which case the missed dose should be skipped; doses should not be doubled.

Side effects of Bisoprolol Fumarate + Amlodipine arise from its two components.

Common

• Peripheral edema (ankle/leg swelling), primarily from the amlodipine component
• Fatigue and tiredness
• Dizziness or light-headedness
• Headache
• Flushing
• Bradycardia (slow heart rate)
• Palpitations

Less Common/Serious

• Symptomatic hypotension
• Worsening of heart failure symptoms (shortness of breath, weight gain, edema)
• Cold extremities/worsening of peripheral vascular symptoms
• Bronchospasm (more likely in patients with reactive airway disease)
• Mood changes, sleep disturbance
• Gingival hyperplasia (rare, with prolonged amlodipine use)

Patients should seek prompt medical advice for severe dizziness, fainting, very slow heart rate, chest pain, or marked swelling while taking Bisoprolol Fumarate + Amlodipine.