10% Off
Probis Plus5 mg+6.25
ACI Limited
৳90.27
Add to cart
Generic medicine
Bisoprolol Fumarate + Hydrochlorothiazide: Brands, Price & Uses in Bangladesh
Bisoprolol Fumarate + Hydrochlorothiazide is a fixed-dose combination product containing bisoprolol fumarate, a beta-1 selective (cardioselective) adrenergic receptor blocker, and hydrochlorothiazide and more.
About Bisoprolol Fumarate + Hydrochlorothiazide
Indications of Bisoprolol Fumarate + Hydrochlorothiazide
Bisoprolol Fumarate + Hydrochlorothiazide is a fixed-dose combination product containing bisoprolol fumarate, a beta-1 selective (cardioselective) adrenergic receptor blocker, and hydrochlorothiazide, a thiazide diuretic. It is FDA-approved for the following use:
- Hypertension (established/FDA-approved use): Bisoprolol Fumarate + Hydrochlorothiazide is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
Bisoprolol Fumarate + Hydrochlorothiazide is generally used as a second-line combination therapy - that is, in patients whose blood pressure is not adequately controlled on either component (a beta-blocker or a thiazide diuretic) alone, or as maintenance therapy once individual doses of each component have been titrated. Bisoprolol Fumarate + Hydrochlorothiazide is not intended for initial therapy of hypertension unless a physician determines that the patient is likely to need multiple drugs to achieve their blood pressure goal.
This combination is not indicated for conditions such as angina, arrhythmia, or heart failure; individual components have other approved uses but this specific fixed-dose combination is approved for hypertension only.
Dosage & Administration of Bisoprolol Fumarate + Hydrochlorothiazide
General Dosing Principles
Bisoprolol Fumarate + Hydrochlorothiazide is generally used once the individual doses of bisoprolol and hydrochlorothiazide have been separately titrated, or when a patient's hypertension is not adequately controlled by either component alone. Dosing must be individualized by a physician.
| Indication | Population | Typical Dosing |
|---|---|---|
| Hypertension | Adults - initial therapy | One tablet of the lowest strength combination (e.g., 2.5 mg/6.25 mg) once daily, taken in the morning, with or without food. |
| Hypertension | Adults - titration | Dose may be increased at intervals of approximately 14 days, based on blood pressure response, up to a maximum of 20 mg bisoprolol / 12.5 mg hydrochlorothiazide once daily. |
| Hypertension | Renal impairment | Use with caution; thiazides may be less effective and beta-blocker clearance may be reduced in significant renal impairment. Dose adjustment and closer monitoring may be needed - consult a physician. |
| Hypertension | Hepatic impairment | Use with caution; bisoprolol undergoes partial hepatic metabolism. No fixed dose adjustment is well established; individualize dosing. |
Administration
- Take Bisoprolol Fumarate + Hydrochlorothiazide by mouth once daily, generally in the morning, with or without food.
- Swallow the tablet whole with a glass of water; do not crush or chew unless directed by a physician.
- Take at approximately the same time each day to maintain consistent blood pressure control.
- Do not stop Bisoprolol Fumarate + Hydrochlorothiazide abruptly - see Precautions and Warnings regarding gradual dose tapering.
Side Effects of Bisoprolol Fumarate + Hydrochlorothiazide
Like all medicines, Bisoprolol Fumarate + Hydrochlorothiazide can cause side effects, although not everyone experiences them.
Common side effects
- Fatigue or tiredness
- Dizziness or lightheadedness
- Headache
- Bradycardia (slow heart rate)
- Cold hands or feet
- Gastrointestinal upset (nausea, diarrhea)
- Increased urination
Less common but clinically important side effects
- Electrolyte disturbances (low potassium, low sodium, low magnesium) - see Precautions and Warnings
- Photosensitivity (skin reaction to sunlight) - see Precautions and Warnings
- Hyperuricemia and gout flares - see Precautions and Warnings
- Worsening of glucose control in diabetics
- Erectile dysfunction
- Cold extremities or worsening of Raynaud's phenomenon
- Bronchospasm in susceptible individuals - see Precautions and Warnings
Rare but serious side effects (seek medical attention)
- Significant bradycardia or heart block
- Worsening heart failure (swelling, shortness of breath, weight gain)
- Severe allergic reaction (rash, swelling of face/lips/tongue, difficulty breathing)
- Severe electrolyte imbalance (muscle cramps, weakness, irregular heartbeat)
Contraindications of Bisoprolol Fumarate + Hydrochlorothiazide
Bisoprolol Fumarate + Hydrochlorothiazide is contraindicated in patients with:
- Known hypersensitivity to bisoprolol, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the formulation.
- Cardiogenic shock.
- Overt (decompensated) cardiac failure.
- Second- or third-degree atrioventricular (AV) block, without a functioning pacemaker.
- Marked sinus bradycardia.
- Sick sinus syndrome, without a functioning pacemaker.
- Severe peripheral arterial circulatory disorders.
- Anuria.
Additional cautions (e.g., severe asthma/bronchospastic disease, uncontrolled heart failure) are discussed under Precautions and Warnings, as these generally represent relative rather than absolute contraindications requiring careful clinical judgment.
Frequently Asked Questions about Bisoprolol Fumarate + Hydrochlorothiazide
What is Bisoprolol Fumarate + Hydrochlorothiazide used for?
Bisoprolol Fumarate + Hydrochlorothiazide is used to treat high blood pressure (hypertension). It combines a beta-1 selective blocker (bisoprolol) with a thiazide diuretic (hydrochlorothiazide) to lower blood pressure more effectively than either medicine alone, typically once other options have been tried or titrated.
Can I stop taking Bisoprolol Fumarate + Hydrochlorothiazide suddenly if I feel better?
No. You should never stop Bisoprolol Fumarate + Hydrochlorothiazide abruptly, especially if you have coronary artery disease, because sudden discontinuation of the beta-blocker component can cause a rapid rise in blood pressure and heart rate, worsening chest pain (angina), or even a heart attack. If your doctor decides to stop this medicine, the dose will usually be reduced gradually over one to two weeks.
Is Bisoprolol Fumarate + Hydrochlorothiazide safe during pregnancy?
Bisoprolol Fumarate + Hydrochlorothiazide should be used during pregnancy only if clearly needed and if your doctor decides the benefit outweighs the risk. Both the beta-blocker and the thiazide diuretic components have been associated with potential effects on the fetus, including slow heart rate, low blood sugar, growth restriction, and electrolyte disturbances. Please consult your physician promptly if you are pregnant or planning to become pregnant while taking Bisoprolol Fumarate + Hydrochlorothiazide.
What side effects should I watch for with Bisoprolol Fumarate + Hydrochlorothiazide?
Common side effects include tiredness, dizziness, slow heart rate, headache, and increased urination. More serious effects to watch for include very slow heart rate, signs of worsening heart failure (swelling, shortness of breath), muscle cramps or weakness from electrolyte imbalance, and allergic reactions. Contact your doctor promptly if you experience any of these while taking Bisoprolol Fumarate + Hydrochlorothiazide.
Can people with asthma take Bisoprolol Fumarate + Hydrochlorothiazide?
Generally, no. Bisoprolol Fumarate + Hydrochlorothiazide contains a beta-blocker, and patients with asthma or other bronchospastic lung disease should, in general, not receive beta-blockers because they can trigger bronchospasm and worsen breathing. Discuss alternative treatments with your doctor if you have asthma or COPD.
Does Bisoprolol Fumarate + Hydrochlorothiazide affect blood sugar or diabetes management?
Bisoprolol Fumarate + Hydrochlorothiazide can affect diabetes management in two ways: the beta-blocker component can mask some warning signs of low blood sugar (like a fast heartbeat), and the thiazide component can raise blood sugar levels. If you have diabetes, monitor your blood glucose closely and discuss appropriate monitoring with your physician while taking Bisoprolol Fumarate + Hydrochlorothiazide.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.