Cefuroxime Axetil + Clavulanic Acid: Brands, Price & Uses in Bangladesh

Cefuroxime Axetil + Clavulanic Acid is a combination oral antibiotic used to treat bacterial infections caused by susceptible organisms, including many beta-lactamase-producing strains that would otherwise resist cefuroxime alone.

Established / commonly used indications

• Pharyngitis and tonsillitis
• Acute bacterial otitis media
• Acute bacterial sinusitis
• Acute bacterial exacerbations of chronic bronchitis and other lower respiratory tract infections
• Uncomplicated skin and skin-structure infections
• Uncomplicated urinary tract infections

Uses requiring specialist/combination therapy or supported mainly by local prescribing practice

• ENT infections in patients with a history of, or risk factors for, beta-lactamase-producing resistant organisms
• As oral step-down therapy for lower respiratory tract infections after an initial course of parenteral antibiotics, under physician guidance

Cefuroxime Axetil + Clavulanic Acid should be used only for infections proven or strongly suspected to be caused by susceptible bacteria, based on culture and sensitivity data or local resistance patterns, to reduce the development of drug-resistant bacteria. It is not effective against viral infections such as the common cold or flu.

The dose and duration of Cefuroxime Axetil + Clavulanic Acid depend on the type and severity of infection. Tablet and oral suspension formulations of Cefuroxime Axetil + Clavulanic Acid are not necessarily bioequivalent on a mg-to-mg basis and should not be interchanged without medical advice.

Doses above refer to the cefuroxime component; the clavulanic acid component is proportioned automatically within each approved tablet/suspension strength and should not be dosed separately. Cefuroxime Axetil + Clavulanic Acid tablets are best taken with food to improve absorption and reduce gastrointestinal upset; tablets should be swallowed whole and not crushed or chewed because of the bitter taste of the active drug. Patients who cannot swallow tablets should use the oral suspension formulation instead.

Antibiotic stewardship: Take Cefuroxime Axetil + Clavulanic Acid exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice.

Dose or interval adjustment may be required in patients with significant renal impairment; see Use in Special Populations.

Cefuroxime Axetil + Clavulanic Acid is generally well tolerated. Reported adverse effects include:

Common

• Diarrhea
• Nausea and vomiting
• Abdominal discomfort
• Headache
• Vaginal itching or vaginitis (in females)

Less common

• Skin rash or urticaria
• Transient elevation of liver enzymes
• Eosinophilia

Rare but serious

• Severe hypersensitivity/anaphylaxis
• Stevens-Johnson syndrome and toxic epidermal necrolysis
• Clostridioides difficile-associated diarrhea/colitis (see Precautions and Warnings)
• Cholestatic jaundice/hepatitis, mainly attributed to the clavulanic acid component, usually reversible on stopping treatment (see Contraindications)
• Seizures (typically with very high doses or in renal impairment)

Patients should seek prompt medical attention for any severe rash, difficulty breathing, swelling, yellowing of the skin/eyes, or persistent diarrhea while taking Cefuroxime Axetil + Clavulanic Acid.