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Dionem500 mg/via
Opsonin Pharma Ltd.
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Generic medicine
Doripenem: Brands, Price & Uses in Bangladesh
Doripenem is a broad-spectrum carbapenem antibiotic.
About Doripenem
Indications of Doripenem
Doripenem is a broad-spectrum carbapenem antibiotic. Its FDA-approved (established) indications are:
- Complicated intra-abdominal infections caused by susceptible bacteria.
- Complicated urinary tract infections (UTIs), including pyelonephritis, caused by susceptible bacteria.
Doripenem is generally reserved for serious, hospital-treated infections, including those caused by multidrug-resistant organisms, and is typically used when other antibiotics are unsuitable or have failed.
Important safety note: Doripenem is not approved for the treatment of ventilator-associated bacterial pneumonia, as clinical studies showed higher mortality with Doripenem compared to a comparator carbapenem in that setting. Use for pneumonia is considered inappropriate off-label use and should be avoided.
Dosage & Administration of Doripenem
Doripenem is administered only by intravenous (IV) infusion in a hospital or supervised healthcare setting; it is not available as an oral formulation.
Complicated intra-abdominal infections
500 mg by IV infusion over 1 hour every 8 hours, for 5 to 14 days, depending on clinical response.
Complicated urinary tract infections, including pyelonephritis
500 mg by IV infusion over 1 hour every 8 hours, for 10 days (up to 14 days if bacteremia is present).
| Creatinine Clearance (CrCl) | Recommended Dose of Doripenem |
|---|---|
| Greater than 50 mL/min | 500 mg every 8 hours (no adjustment) |
| 30 to 50 mL/min | 250 mg every 8 hours |
| 10 to less than 30 mL/min | 250 mg every 12 hours |
| Hemodialysis / severe renal impairment | Insufficient data; use with caution and close monitoring |
Antibiotic stewardship: Take Doripenem exactly as prescribed by your physician. Do not stop, extend, skip doses, or share this medicine with others without medical advice, even if symptoms improve before the course is completed, as this can promote antibiotic resistance and treatment failure.
Side Effects of Doripenem
Common side effects (occurring in approximately 5% or more of patients) include:
- Headache
- Nausea and diarrhea
- Rash
- Phlebitis (vein inflammation at the infusion site)
Less common but serious adverse effects that require prompt medical attention include:
- Severe allergic reactions (anaphylaxis), including swelling of the face/throat, difficulty breathing, or severe skin reactions such as Stevens-Johnson syndrome.
- Clostridioides difficile-associated diarrhea, which can range from mild to life-threatening colitis, and may occur up to several weeks after treatment ends.
- Seizures (see Precautions and Warnings).
- Blood disorders such as low white blood cell counts (leukopenia/neutropenia).
- Liver enzyme elevations.
Contraindications of Doripenem
Doripenem is contraindicated in patients with:
- Known hypersensitivity to Doripenem or to other drugs in the carbapenem class.
- A history of anaphylactic (severe, immediate hypersensitivity) reactions to beta-lactam antibiotics, due to the risk of cross-reactivity.
Frequently Asked Questions about Doripenem
What is Doripenem used for?
Doripenem is an intravenous antibiotic used to treat serious infections such as complicated intra-abdominal infections and complicated urinary tract infections, including kidney infections (pyelonephritis), caused by susceptible bacteria. It is generally reserved for moderate to severe infections managed in a hospital setting.
Can Doripenem be taken by mouth?
No. Doripenem is only available as an intravenous (IV) infusion given by healthcare professionals; there is no oral tablet or capsule form.
Who should not receive Doripenem?
Doripenem should not be given to anyone with known hypersensitivity to Doripenem or other carbapenem antibiotics, or a history of anaphylactic reaction to any beta-lactam antibiotic (such as penicillins or cephalosporins), due to the risk of a severe allergic reaction.
Is Doripenem safe during pregnancy or breastfeeding?
Doripenem should be used during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus; consult a physician. It is not known if Doripenem passes into breast milk, so caution is advised and a doctor should be consulted before breastfeeding while receiving Doripenem.
What are the common side effects of Doripenem?
Common side effects of Doripenem include headache, nausea, diarrhea, rash, and inflammation at the IV infusion site (phlebitis). Serious but less common effects include severe allergic reactions, seizures, and severe diarrhea caused by C. difficile infection — seek medical attention promptly if these occur.
Can Doripenem cause seizures?
Yes, like other carbapenem antibiotics, Doripenem can lower the seizure threshold, particularly in patients with a history of seizures, brain disorders, or kidney impairment. It also interacts with valproic acid, reducing its levels and increasing seizure risk, so this combination is generally avoided. Tell your doctor about any seizure history or other medications before receiving Doripenem.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.