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Fructin10%w/v
Beximco Pharmaceuticals Ltd.
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Fructose: Brands, Price & Uses in Bangladesh
Fructose is a naturally occurring simple sugar (monosaccharide) with the following pharmaceutical and clinical uses: Established/well-recognized uses Parenteral (intravenous) fluid and caloric…
About Fructose
Indications of Fructose
Fructose is a naturally occurring simple sugar (monosaccharide) with the following pharmaceutical and clinical uses:
Established/well-recognized uses
- Parenteral (intravenous) fluid and caloric supplementation: Fructose solutions (e.g., 10% w/v) have been used as an alternative carbohydrate energy source to dextrose (glucose) in intravenous fluid and short-term nutritional support, particularly in situations where an insulin-independent carbohydrate source was historically preferred.
- Pharmaceutical excipient/sweetening agent: Fructose is widely used as a sweetener, flavoring agent, and inactive ingredient in oral liquids, tablets, and nutritional/rehydration formulations.
Adjunct/supportive use
- As a component of some oral rehydration or nutritional supplement formulations, usually in combination with other carbohydrates or electrolytes rather than as a sole therapeutic agent.
Note: Because of safety concerns (see Precautions and Warnings), intravenous Fructose has been largely superseded by dextrose-based solutions in many countries, though it may still be available and used in specific clinical or regional contexts.
Dosage & Administration of Fructose
General principles
Dosing of Fructose depends entirely on the clinical indication and formulation; it is not administered as a fixed oral "tablet dose" in the way conventional drugs are.
| Indication/Use | Typical dosing approach |
|---|---|
| Intravenous fluid/caloric support | Fructose solution (commonly 10% w/v) infused intravenously at a rate individualized to the patient's fluid, caloric, and clinical status. Slow infusion rates are used to minimize the risk of lactic acidosis and hyperuricemia; rapid or high-dose infusion should be avoided. Exact volume and rate are determined by the treating physician based on body weight, fluid balance, and metabolic monitoring. |
| Oral/excipient use (sweetener in liquid or solid formulations) | Present only in the small quantities needed for palatability/formulation; not intended to provide a therapeutic dose in this context. |
Administration
Intravenous Fructose solutions are administered by slow, controlled intravenous infusion under medical supervision, with monitoring of blood glucose, lactate, and uric acid, particularly during prolonged or high-volume infusions. Oral formulations containing Fructose as an excipient are taken/administered according to the specific product's directions.
Side Effects of Fructose
Adverse effects associated with Fructose depend on the route and rate of administration:
With intravenous use
- Lactic acidosis (particularly with rapid or high-dose infusion)
- Hyperuricemia (may precipitate or worsen gout)
- Mild hyperglycemia (via hepatic conversion of fructose to glucose)
- Infusion-site reactions (phlebitis, pain, irritation)
- Fluid overload if infused in excessive volume
With oral use (as excipient/sweetener, at higher intake)
- Gastrointestinal discomfort — bloating, abdominal pain, diarrhea (more likely in individuals with fructose malabsorption, a distinct and less severe condition than hereditary fructose intolerance)
Hypersensitivity reactions are rare. Seek medical attention if severe or unexpected symptoms occur.
Contraindications of Fructose
Fructose is absolutely contraindicated in:
- Hereditary fructose intolerance (HFI): A potentially fatal inherited disorder (aldolase B deficiency) in which Fructose administration can cause severe hypoglycemia, liver and kidney damage, and death. This is an absolute contraindication.
- Fructose-1,6-diphosphatase deficiency: Another inherited disorder of fructose/gluconeogenic metabolism in which Fructose exposure can precipitate severe hypoglycemia and lactic acidosis.
- Known hypersensitivity to Fructose or any component of the specific formulation.
Frequently Asked Questions about Fructose
What is Fructose used for?
Fructose is a simple sugar used medically as an intravenous fluid and caloric supplement (as an alternative to dextrose in certain situations) and as an excipient/sweetening agent in oral pharmaceutical and nutritional products. See Indications for details.
Who should never receive Fructose?
People with hereditary fructose intolerance or fructose-1,6-diphosphatase deficiency must never receive Fructose, as it can cause severe, potentially fatal hypoglycemia and organ damage in these inherited conditions. People with known hypersensitivity to Fructose should also avoid it. These are absolute contraindications.
Is Fructose safe for people with diabetes?
Fructose is absorbed and initially metabolized somewhat independently of insulin, but it is still converted to glucose in the liver and can raise blood glucose levels. People with diabetes mellitus should only receive Fructose under medical supervision with appropriate glucose monitoring.
Can Fructose be used during pregnancy or breastfeeding?
As an ordinary dietary sugar, Fructose in normal food amounts is not a specific concern in pregnancy or lactation. However, as a pharmaceutical or intravenous agent, Fructose should be used in pregnancy or breastfeeding only if clearly needed, with the potential benefit outweighing potential risk, and only after consulting a physician.
What are the signs of a Fructose overdose or adverse reaction, and what should I do?
Excessive or rapid Fructose administration, especially intravenously, can cause lactic acidosis, hyperuricemia, and (in undiagnosed hereditary fructose intolerance or fructose-1,6-diphosphatase deficiency) severe hypoglycemia and organ dysfunction. If this is suspected, stop the infusion and seek immediate emergency medical attention or contact a poison control center; do not attempt home treatment.
Can babies safely receive Fructose?
Not unless hereditary fructose intolerance and fructose-1,6-diphosphatase deficiency have first been ruled out, because an undiagnosed infant can develop severe, potentially fatal reactions to Fructose. This is why Fructose-containing IV fluids or formulas are avoided in neonates and young infants without prior screening.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.