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Irigate1.5%
ACME Laboratories Ltd.
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Generic medicine
Glycine: Brands, Price & Uses in Bangladesh
Glycine 1.5% w/v solution is a non-electrolyte, isosmotic irrigating fluid used to distend and irrigate the surgical field during certain electrosurgical endoscopic procedures.
About Glycine
Indications of Glycine
Glycine 1.5% w/v solution is a non-electrolyte, isosmotic irrigating fluid used to distend and irrigate the surgical field during certain electrosurgical endoscopic procedures. Its main established (labeled) use is as a genitourinary irrigant, since it does not conduct electricity and therefore does not disperse energy during monopolar electrocautery.
Established uses
- Bladder/urethral irrigation during transurethral resection of the prostate (TURP) and transurethral resection of bladder tumors (TURBT).
- Uterine cavity distension/irrigation during operative hysteroscopy (e.g., resection of fibroids, polyps, or endometrial ablation) using monopolar electrosurgical instruments.
Other use (nutritional/off-label)
Glycine is also used orally in some settings as a nutritional/dietary amino acid supplement; preliminary evidence has explored its use for sleep quality and as an adjunct in certain metabolic and psychiatric contexts, but such uses are not formally approved indications and evidence remains limited.
Dosage & Administration of Glycine
Dosage and use of Glycine irrigation solution depend on the surgical procedure being performed and must be determined by the operating surgeon, urologist, or gynecologist. See Dosage and Administration below for indication-specific details. Procedure duration should be minimized where possible to reduce systemic fluid absorption, and fluid deficit (input minus output) should be monitored throughout the procedure.
Side Effects of Glycine
When used appropriately as a surgical irrigant, local side effects are uncommon. The main safety concern is systemic absorption of Glycine solution during prolonged or extensive procedures, which can cause a constellation of effects sometimes called "TURP syndrome," including:
- Dilutional hyponatremia (nausea, vomiting, confusion, headache, and seizures in severe cases)
- Transient visual disturbances, including temporary blindness ("glycine toxicity")
- Hyperammonemia (drowsiness, confusion)
- Bradycardia, hypertension or hypotension, and fluid overload/pulmonary edema in severe cases
Oral Glycine supplementation is generally well tolerated; mild gastrointestinal upset, nausea, or drowsiness have been reported infrequently at higher doses.
Contraindications of Glycine
Glycine irrigation solution is contraindicated in patients with known hypersensitivity to glycine. It must not be administered by intravenous or other parenteral injection; it is intended for irrigation use only.
Frequently Asked Questions about Glycine
What is Glycine irrigation solution used for?
Glycine 1.5% solution is mainly used by surgeons as an irrigating/distension fluid during procedures such as transurethral resection of the prostate (TURP) and operative hysteroscopy, because it does not conduct electricity and works safely with electrocautery instruments.
Is Glycine irrigation solution safe?
When used correctly by trained medical staff with proper monitoring, Glycine irrigation is generally safe. The main risk is excessive absorption of the fluid into the bloodstream during long procedures, which can cause a condition called "TURP syndrome" with symptoms like confusion, visual disturbances, and low blood sodium; your surgical team monitors for this throughout the procedure.
Can Glycine be given as an injection?
No. Glycine irrigation solution is intended for irrigation of the bladder or uterine cavity only and must never be given as an intravenous or other injection.
Is Glycine safe during pregnancy?
Glycine should be used during pregnancy only if clearly needed, and only when the potential benefit outweighs the potential risk to the baby, as determined by your physician; there is limited controlled safety data available.
Can Glycine be taken as a supplement?
Yes, Glycine is also available as an oral amino acid supplement in some products and is generally well tolerated at typical doses, though evidence for specific health claims (such as improved sleep) is still preliminary. Always consult a physician before starting any supplement.
What should I do if too much Glycine solution is absorbed during surgery?
This is monitored and managed by your surgical team during the procedure. If you notice symptoms such as confusion, visual changes, or feeling unwell after a procedure using Glycine irrigation, seek immediate medical attention.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.