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Hyoscine Butylbromide: Brands, Price & Uses in Bangladesh
Hyoscine Butylbromide is an antimuscarinic (anticholinergic) antispasmodic used to relieve smooth-muscle spasm and colic arising in the gastrointestinal and genitourinary tracts.
About Hyoscine Butylbromide
Indications of Hyoscine Butylbromide
Hyoscine Butylbromide is an antimuscarinic (anticholinergic) antispasmodic used to relieve smooth-muscle spasm and colic arising in the gastrointestinal and genitourinary tracts. It is widely used and marketed internationally (including in Bangladesh) for this purpose; it is not an FDA-approved product for human use in the United States, where an antimuscarinic-class oral or injectable equivalent may instead be prescribed.
- Acute gastrointestinal spasm/colic - painful spasm of the stomach and intestine, including spasm associated with irritable bowel syndrome (established/widely used indication).
- Biliary colic - spasm of the bile ducts and gallbladder (established/widely used indication).
- Renal/ureteric colic - spasm of the urinary tract, usually as an adjunct alongside analgesia and definitive management of the underlying cause (adjunct use).
- Primary dysmenorrhoea - painful menstrual cramping (oral tablet formulation; established/widely used indication).
- Muscle relaxation during diagnostic or therapeutic procedures - e.g. endoscopy, colonoscopy, or radiological/imaging studies of the abdomen, where reducing bowel spasm improves visualisation (established adjunct/procedural use, injectable formulation).
Hyoscine Butylbromide only relieves the spasm and pain; it does not treat the underlying cause, so persistent or recurrent abdominal pain should always be medically investigated.
Dosage & Administration of Hyoscine Butylbromide
| Indication/Population | Route | Typical Dose |
|---|---|---|
| Adults & adolescents ≥12 years - GI/GU spasm, colic | Oral (tablet) | 10-20 mg, 3-4 times daily (maximum 100 mg/day) |
| Adults - dysmenorrhoea | Oral (tablet) | 10-20 mg, 3-4 times daily, starting a day or two before expected onset of menses and continued through the first days of the period |
| Children 6-12 years - GI spasm | Oral (tablet) | 10 mg, 3 times daily, under medical supervision |
| Children under 6 years | Oral | Not recommended; safety and efficacy not established |
| Adults - acute spasm/colic, pre-procedure | IM/SC/slow IV injection | 10-20 mg (0.5-1 mL) as a single dose, may be repeated after 20-30 minutes if needed (maximum 100 mg/day) |
| Children - injection | Parenteral | Not currently recommended; use only under specialist medical supervision if no alternative |
Treat with the lowest effective dose for the shortest period needed to control symptoms. If abdominal pain persists or recurs despite Hyoscine Butylbromide, the underlying cause should be medically investigated rather than continuing indefinite use.
Side Effects of Hyoscine Butylbromide
Side effects of Hyoscine Butylbromide arise mainly from its antimuscarinic action and are usually mild and reversible.
- Common: dry mouth, reduced sweating, dizziness, drowsiness.
- Less common: tachycardia (fast heart rate), blurred vision/accommodation disturbance, constipation, urinary hesitancy or retention, skin flushing.
- Rare but serious: hypersensitivity reactions including skin rash, urticaria, angioedema, dyspnoea, and, very rarely, anaphylactic shock (including fatal cases have been reported with the injection); marked hypotension.
Seek urgent medical attention for any signs of a serious allergic reaction (facial/throat swelling, severe rash, breathing difficulty) while using Hyoscine Butylbromide.
Contraindications of Hyoscine Butylbromide
Hyoscine Butylbromide is contraindicated in patients with:
- Known hypersensitivity to Hyoscine Butylbromide or to any other antimuscarinic agent or product excipient.
- Myasthenia gravis (antimuscarinic blockade can worsen muscle weakness).
- Mechanical gastrointestinal obstruction, including pyloric stenosis, and paralytic ileus.
- Megacolon/toxic megacolon.
- Untreated (uncontrolled) angle-closure (narrow-angle) glaucoma (antimuscarinic effect can precipitate a sight-threatening rise in intraocular pressure).
- Urinary retention due to bladder outlet or prostatic obstruction.
- Significant unstable tachyarrhythmia.
Hyoscine Butylbromide should not be used in any of these conditions; other cautions (e.g. prostatic hypertrophy without retention, cardiac disease, ulcerative colitis) require careful physician judgement rather than absolute avoidance - see Precautions and Warnings.
Frequently Asked Questions about Hyoscine Butylbromide
What is Hyoscine Butylbromide used for?
Hyoscine Butylbromide is used to relieve painful spasm and cramping in the stomach, intestines, gallbladder/bile ducts and urinary tract, and for painful menstrual cramps (dysmenorrhoea). It is also used to relax bowel spasm before certain diagnostic procedures such as endoscopy.
How should I take Hyoscine Butylbromide?
Adults typically take 10-20 mg of Hyoscine Butylbromide by mouth 3-4 times daily (maximum 100 mg/day), swallowed with water, preferably before meals. The injectable form is given by a healthcare professional. Always follow your physician's specific instructions.
Who should not take Hyoscine Butylbromide?
Hyoscine Butylbromide should not be used by people with myasthenia gravis, mechanical bowel obstruction or paralytic ileus, megacolon, untreated angle-closure glaucoma, urinary retention due to prostatic or bladder outlet obstruction, significant uncontrolled fast heart rhythms, or known hypersensitivity to the drug. Tell your doctor about your full medical history before starting Hyoscine Butylbromide.
Can Hyoscine Butylbromide be used during pregnancy or breastfeeding?
Data are limited. Hyoscine Butylbromide should be used in pregnancy only if clearly needed, when potential benefit justifies potential risk to the fetus, and only under medical advice, particularly in the first trimester. It is not known whether it passes into breast milk in significant amounts, so use while breastfeeding should also be guided by a physician.
What are the common side effects of Hyoscine Butylbromide?
The most common side effects of Hyoscine Butylbromide are dry mouth, reduced sweating, dizziness and drowsiness. Less commonly it can cause a fast heartbeat, blurred vision, constipation, or difficulty passing urine. Rarely, serious allergic reactions (including anaphylaxis) can occur, especially with the injection - seek urgent medical help if this happens.
What should I do if I take too much Hyoscine Butylbromide?
An overdose of Hyoscine Butylbromide can cause dry mouth, blurred vision, a fast heart rate, urinary retention, agitation or drowsiness, and in severe cases more serious effects. Seek immediate medical attention or contact emergency services/poison control right away; do not try to manage an overdose at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.