Indacaterol + Glycopyrronium: Brands, Price & Uses in Bangladesh

Indacaterol + Glycopyrronium is an inhaled combination of a long-acting beta2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA), indicated for the following uses:

Established / Approved Use

• Long-term maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

Important Limitations

• Indacaterol + Glycopyrronium is not indicated for the treatment of asthma. LABA-containing medicines used without an inhaled corticosteroid are associated with an increased risk of asthma-related death.
• Indacaterol + Glycopyrronium is not a rescue inhaler and must not be used to treat acute symptoms of COPD or acute bronchospasm. A separate short-acting bronchodilator should be prescribed and kept on hand for acute relief.

Indacaterol + Glycopyrronium is intended for once-daily, regular maintenance use, not for as-needed symptom relief.

Adult Dose (COPD maintenance)

Method of Administration

• Capsules are for oral inhalation only using the dedicated inhaler device provided with the product - they must never be swallowed.
• Remove one capsule from the blister immediately before use; do not store capsules outside the blister.
• Place the capsule in the chamber of the inhaler, pierce it once, and inhale the powder in one or two deep, forceful breaths as instructed by the physician/pharmacist or package leaflet.
• Do not exceed the prescribed dose or frequency.

Pediatric Dose

Not applicable - Indacaterol + Glycopyrronium is not indicated for use in children; safety and efficacy have not been established.

Renal/Hepatic Impairment

No dose adjustment is generally required in mild-to-moderate renal or hepatic impairment. Use with caution and under close medical supervision in severe renal impairment (including end-stage renal disease) or severe hepatic impairment, as clinical experience is limited (see Use in Special Populations).

Side effects reported with Indacaterol + Glycopyrronium are generally related to its two components (a LABA and a LAMA):

Common

• Dry mouth
• Cough
• Headache
• Nasopharyngitis (common cold-type symptoms)
• Dizziness
• Oropharyngeal pain
• Muscle spasms or pain in extremities

Cardiovascular (beta-agonist related)

• Tachycardia and palpitations
• Hypertension
• Rarely, cardiac arrhythmias (including atrial fibrillation)

Anticholinergic-related

• Urinary retention or difficulty urinating, particularly in patients with pre-existing bladder outlet obstruction or prostatic hyperplasia
• Constipation

Uncommon/Rare but Important

• Paradoxical bronchospasm (immediately after inhalation - discontinue and seek urgent medical attention if this occurs)
• Hypersensitivity reactions (rash, urticaria, angioedema)
• Blurred vision or eye pain suggestive of acute narrow-angle glaucoma

Patients experiencing severe or persistent side effects should contact their physician promptly.