10% Off
I-Penam1 gm/vial
Incepta Pharmaceuticals Ltd.
৳1170.00
Add to cart
Generic medicine
Meropenem Trihydrate: Brands, Price & Uses in Bangladesh
Meropenem Trihydrate is a broad-spectrum carbapenem antibiotic administered by intravenous injection or infusion and more.
About Meropenem Trihydrate
Indications of Meropenem Trihydrate
Meropenem Trihydrate is a broad-spectrum carbapenem antibiotic administered by intravenous injection or infusion, reserved for treatment of serious and often resistant bacterial infections under hospital or close medical supervision.
Established / FDA-approved uses
- Complicated intra-abdominal infections (e.g. peritonitis, complicated appendicitis)
- Complicated skin and skin structure infections
- Bacterial meningitis (pediatric patients 3 months and older; also used in adults based on guideline support)
Guideline-supported / widely used indications
- Hospital-acquired and ventilator-associated (nosocomial) pneumonia
- Complicated urinary tract infections
- Septicaemia (bloodstream infections) and sepsis due to susceptible organisms
- Gynaecological infections, including endometritis
- Empiric treatment of presumed infection in febrile neutropenia (used as part of combination or empiric regimens)
- Infections caused by multidrug-resistant Gram-negative organisms when susceptibility is confirmed
Adjunct / specialised use
- Pulmonary exacerbations in cystic fibrosis patients (guideline/expert-supported use)
Meropenem Trihydrate should be used based on culture and sensitivity results whenever possible, and is generally reserved for serious infections or as an alternative when first-line antibiotics are unsuitable.
Dosage & Administration of Meropenem Trihydrate
Meropenem Trihydrate is administered only by intravenous (IV) bolus injection (over approximately 3-5 minutes) or IV infusion (over approximately 15-30 minutes), under medical or hospital supervision. It is not given orally or intramuscularly.
Adult dosing (normal renal function)
| Indication | Dose | Frequency |
|---|---|---|
| Complicated skin/skin structure infections | 500 mg IV | Every 8 hours |
| Complicated intra-abdominal infections | 1 g IV | Every 8 hours |
| Hospital-acquired pneumonia, septicaemia, severe infections (including those due to Pseudomonas) | 1 g IV | Every 8 hours |
| Bacterial meningitis | 2 g IV | Every 8 hours |
Pediatric dosing (3 months to 12 years, normal renal function)
| Indication | Dose | Frequency |
|---|---|---|
| Complicated skin/skin structure infections | 10 mg/kg (max 500 mg) | Every 8 hours |
| Complicated intra-abdominal infections | 20 mg/kg (max 1 g) | Every 8 hours |
| Bacterial meningitis | 40 mg/kg (max 2 g) | Every 8 hours |
Children weighing more than 50 kg should receive adult dosing. Safety and efficacy in infants under 3 months have not been established.
Renal impairment (adults)
| Creatinine clearance | Dose adjustment |
|---|---|
| >50 mL/min | Standard dose, every 8 hours |
| 26-50 mL/min | Standard dose, every 12 hours |
| 10-25 mL/min | Half the standard dose, every 12 hours |
| <10 mL/min | Half the standard dose, every 24 hours; supplemental dosing after haemodialysis is recommended |
Antibiotic stewardship notice: Take Meropenem Trihydrate exactly as prescribed by your physician; do not stop, extend, skip doses, or share this medicine with others without medical advice.
Side Effects of Meropenem Trihydrate
Most adverse effects with Meropenem Trihydrate are mild to moderate. Commonly reported effects (each in ≤2% of patients) include:
- Diarrhea, nausea, vomiting, constipation
- Headache
- Rash, pruritus (itching)
- Pain, inflammation, or thrombophlebitis at the injection site
- Anemia and other changes in blood counts
- Elevated liver enzymes
Less common but serious effects include hypersensitivity reactions (see Contraindications and Precautions), Clostridioides difficile-associated diarrhea (see Precautions), seizures and other CNS effects (see Precautions), and rare reports of severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and hemolytic anemia. Report any severe or persistent symptoms to your physician promptly.
Contraindications of Meropenem Trihydrate
Meropenem Trihydrate is contraindicated in patients with known hypersensitivity to meropenem or to other carbapenem antibiotics.
It is also contraindicated in patients who have had an anaphylactic reaction to other beta-lactam antibiotics (penicillins, cephalosporins), due to the possibility of cross-sensitivity.
Frequently Asked Questions about Meropenem Trihydrate
What is Meropenem Trihydrate used for?
Meropenem Trihydrate is a broad-spectrum carbapenem antibiotic given by injection to treat serious bacterial infections such as complicated intra-abdominal infections, complicated skin and soft tissue infections, bacterial meningitis, hospital-acquired pneumonia, and severe or multidrug-resistant infections, under close medical supervision.
Can Meropenem Trihydrate be taken orally?
No. Meropenem Trihydrate is only given by intravenous (IV) injection or infusion by a healthcare professional; it is not available as an oral tablet or capsule.
Is Meropenem Trihydrate safe during pregnancy?
Data on Meropenem Trihydrate in human pregnancy are limited. It should be used during pregnancy only if clearly needed and if the potential benefit justifies the potential risk to the fetus, and only under a physician's guidance.
What are the common side effects of Meropenem Trihydrate?
Common side effects of Meropenem Trihydrate include diarrhea, nausea, vomiting, constipation, headache, rash, and pain or irritation at the injection site. Serious but less common effects include allergic reactions, Clostridioides difficile-associated diarrhea, and seizures, particularly in patients with kidney impairment or existing CNS conditions.
Can Meropenem Trihydrate be used with valproic acid?
Concurrent use of Meropenem Trihydrate with valproic acid or divalproex sodium is generally not recommended, because Meropenem Trihydrate can significantly lower valproic acid blood levels and increase the risk of breakthrough seizures. If both are necessary, your physician will monitor closely and may add supplemental anticonvulsant therapy.
What should I do if I miss a dose or the treatment course is incomplete?
Since Meropenem Trihydrate is given in a hospital or clinical setting by a healthcare professional, dosing timing is managed by the medical team. It is important to complete the full prescribed course of Meropenem Trihydrate and not stop, extend, skip doses, or share this medicine with others without medical advice, to ensure the infection is fully treated and to reduce the risk of antibiotic resistance.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.