Omeprazole: Brands, Price & Uses in Bangladesh

Gastroesophageal Reflux Disease (GERD)

Omeprazole is FDA-approved for the treatment of symptomatic GERD and for the treatment and maintenance of healing of erosive esophagitis.

Duodenal Ulcer

Omeprazole is FDA-approved for short-term treatment (typically 4 weeks) of active duodenal ulcer, and, in combination with antibacterial regimens, for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence.

Gastric Ulcer

Omeprazole is FDA-approved for short-term treatment (4-8 weeks) of active benign gastric ulcer.

NSAID-Associated Ulcer

Omeprazole is FDA-approved for risk reduction of NSAID-associated gastric ulcer in patients requiring continued NSAID use, and for healing of NSAID-associated ulcers.

Helicobacter pylori Eradication

Omeprazole is FDA-approved as part of combination regimens (with antibiotics such as clarithromycin and amoxicillin) for H. pylori eradication; it is not effective as monotherapy for this indication and requires combination therapy.

Pathological Hypersecretory Conditions

Omeprazole is FDA-approved for long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis.

Prevention of Acid Aspiration / Stress Ulcer Prophylaxis (Adjunct, Guideline/Practice-Supported Use)

Omeprazole is also used, based on clinical practice and guideline support rather than a specific FDA-labeled indication in every case, for prophylaxis of acid aspiration during general anesthesia and for stress ulcer prophylaxis in select critically ill patients; such use should be directed by a physician.

Dosing of Omeprazole depends on the indication being treated, the patient's age, and whether treatment is for short-term healing or long-term maintenance/hypersecretory control. The lowest effective dose for the shortest duration appropriate to the indication should be used, and Omeprazole should be taken exactly as directed by a physician. See Dosage for a per-indication breakdown and Administration for instructions on how to take Omeprazole.

Common Side Effects

The most common side effects reported with Omeprazole include the following:

• Headache
• Abdominal pain
• Nausea and vomiting
• Diarrhea
• Constipation
• Flatulence

Serious Side Effects (Seek Medical Attention)

• Signs of a severe allergic reaction: rash, hives, facial or throat swelling, difficulty breathing, or anaphylaxis
• Severe, watery, or bloody diarrhea that does not improve, which may indicate Clostridioides difficile-associated diarrhea (see Precautions and Warnings)
• Signs of low magnesium: seizures, abnormal or fast heart rhythm, tremors, muscle spasms, or persistent muscle cramps (see Precautions and Warnings)
• New or worsening joint pain with a rash on the cheeks or arms that worsens in sunlight, which may indicate cutaneous or systemic lupus erythematosus
• Yellowing of the skin or eyes, dark urine, or severe stomach pain, which may indicate liver problems
• Severe skin reactions such as blistering or peeling skin (Stevens-Johnson syndrome/toxic epidermal necrolysis)
• Signs of a low blood cell count: unusual bruising, bleeding, fever, or infections that do not go away