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Paloron0.25 mg/5
Ziska Pharmaceuticals Ltd.
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Palonosetron: Brands, Price & Uses in Bangladesh
Chemotherapy-Induced Nausea and Vomiting (CINV) — Established, Adults Intravenous Palonosetron is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and…
About Palonosetron
Indications of Palonosetron
Chemotherapy-Induced Nausea and Vomiting (CINV) — Established, Adults
Intravenous Palonosetron is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy, and for the prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. The oral (tablet/capsule) formulation of Palonosetron is indicated for the prevention of acute nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy in adults; it is not established for the delayed phase or for highly emetogenic regimens.
Postoperative Nausea and Vomiting (PONV) — Established, Adults
Intravenous Palonosetron is indicated for the prevention of postoperative nausea and vomiting for up to 24 hours following surgery.
Chemotherapy-Induced Nausea and Vomiting (CINV) — Established, Pediatric Patients
Intravenous Palonosetron is indicated in pediatric patients 1 month to less than 17 years of age for the prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic chemotherapy. A pediatric indication for the oral formulation and for PONV prevention has not been established.
Dosage & Administration of Palonosetron
General Dosing Principles
Palonosetron dosing and route (intravenous or oral) are determined by a treating physician based on the specific indication, the emetogenic risk of the chemotherapy regimen, and the patient's age — dosing is not the same for every use and must not be assumed to be universal. The intravenous form is administered by a healthcare professional as a single dose timed relative to chemotherapy or surgery; the oral tablet/capsule is taken by mouth as directed before a chemotherapy session.
Side Effects of Palonosetron
Common Side Effects
Headache, constipation, dizziness, diarrhea, and fatigue are the most commonly reported side effects of Palonosetron.
Serious Side Effects — Seek Medical Attention
Seek prompt medical attention for signs of a hypersensitivity reaction (including anaphylaxis), such as rash, swelling of the face/throat, severe itching, or difficulty breathing, which have been reported with intravenous Palonosetron. Also seek medical attention for symptoms suggestive of serotonin syndrome or for palpitations, irregular heartbeat, dizziness, or fainting that could indicate a cardiac rhythm disturbance — see Precautions and Warnings for details on both.
Contraindications of Palonosetron
Palonosetron is contraindicated in patients with known hypersensitivity to Palonosetron or to any component of the formulation.
Frequently Asked Questions about Palonosetron
What is Palonosetron used for?
Palonosetron is used to prevent nausea and vomiting caused by moderately or highly emetogenic cancer chemotherapy (both the acute phase, and for moderately emetogenic regimens, the delayed phase as well), when given intravenously by a healthcare professional. Intravenous Palonosetron is also used to prevent postoperative nausea and vomiting for up to 24 hours after surgery. An oral tablet/capsule form of Palonosetron is separately used to prevent acute nausea and vomiting from moderately emetogenic chemotherapy in adults.
Is Palonosetron given as a tablet or an injection?
Both forms of Palonosetron are marketed — an intravenous injection (given by a healthcare professional before chemotherapy or surgery) and an oral tablet/capsule (taken by mouth before a chemotherapy session). Which form is used depends on the specific clinical situation and the prescriber's decision.
What is the usual dose of Palonosetron?
The dose of Palonosetron depends on the indication: for example, 0.25 mg IV before chemotherapy, 0.075 mg IV before anesthesia for surgery, 0.5 mg orally before chemotherapy in adults, or a weight-based IV dose in children. Dosing is always determined by a healthcare professional and is not the same for every patient or situation — see the dosage table for details.
Can Palonosetron be taken with other medicines?
Palonosetron has a generally low potential for drug interactions, but caution is needed with other serotonergic medicines (such as certain antidepressants) because of a reported risk of serotonin syndrome, and with medicines that affect heart rhythm. Always tell the prescriber or pharmacist about all other medicines being used before starting Palonosetron.
Is Palonosetron safe during pregnancy or breastfeeding?
Human data on Palonosetron use in pregnancy are limited, so it should be used in pregnancy only if a physician judges the benefit outweighs the potential unknown risk. It is not known whether Palonosetron passes into breast milk, so a physician should be consulted to weigh the benefits and risks before using Palonosetron while breastfeeding.
Can children be given Palonosetron?
Intravenous Palonosetron is established for preventing chemotherapy-induced nausea and vomiting in children from 1 month up to less than 17 years of age, at a weight-based dose decided by the treating physician. It has not been established for preventing postoperative nausea and vomiting in children, or as an oral tablet/capsule in patients under 18 years.
What are the common side effects of Palonosetron?
The most commonly reported side effects of Palonosetron are headache, constipation, dizziness, diarrhea, and fatigue. Most are mild, but any signs of an allergic reaction, unusual heartbeat, or symptoms suggestive of serotonin syndrome should be reported to a doctor promptly.
Does Palonosetron affect heart rhythm?
Dedicated studies of Palonosetron have not shown a clinically significant effect on the heart's QT interval, unlike some other medicines in its class. Even so, doctors remain cautious when using Palonosetron in patients who have electrolyte imbalances, a personal or family history of long QT syndrome, or who are taking other medicines that can affect heart rhythm.
What should be done if an overdose of Palonosetron is suspected?
Because Palonosetron is usually given by a healthcare professional in a clinic, hospital, or operating theatre, accidental overdose is uncommon. If an overdose of Palonosetron is suspected, contact a doctor, hospital emergency department, or poison control service right away; do not induce vomiting unless a healthcare professional specifically advises it.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.