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Calcitonin100 IU/ml
City Overseas Ltd.
৳137.75
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Generic medicine
Salmon Calcitonin: Brands, Price & Uses in Bangladesh
Salmon Calcitonin is a polypeptide hormone (derived from salmon calcitonin, more potent per unit than human calcitonin) that inhibits osteoclast-mediated bone resorption.
About Salmon Calcitonin
Indications of Salmon Calcitonin
Salmon Calcitonin is a polypeptide hormone (derived from salmon calcitonin, more potent per unit than human calcitonin) that inhibits osteoclast-mediated bone resorption. Its approved and evidence-based uses include:
- Paget's disease of bone (FDA-approved): Used in symptomatic, moderate-to-severe Paget's disease to reduce bone turnover and relieve bone pain, particularly in patients who cannot use or have not responded to bisphosphonates.
- Hypercalcemia of malignancy (FDA-approved, adjunctive): Used as an adjunct to more definitive therapy (e.g. intravenous fluids, bisphosphonates) for rapid, short-term lowering of serum calcium.
- Postmenopausal osteoporosis (FDA-approved, but now second-line/limited use): Indicated for women more than 5 years postmenopausal, generally reserved for patients unable to use other osteoporosis therapies (e.g. bisphosphonates, hormone therapy) because long-term use has been associated with a small increased risk of malignancy in some analyses; regulatory agencies now recommend restricting duration of use in this indication.
- Acute bone loss from sudden immobilization (guideline-supported, short-term): Occasionally used short-term for immobilization-related bone loss, e.g. after fracture or spinal cord injury.
Use of Salmon Calcitonin beyond short courses should be individualized by a physician, weighing benefit against the malignancy-risk signal described under Precautions.
Dosage & Administration of Salmon Calcitonin
Dosage of Salmon Calcitonin is individualized by indication, formulation, and patient response. Typical regimens are summarized below; always follow the prescribing physician's instructions.
| Indication | Typical Adult Dose | Route |
|---|---|---|
| Paget's disease of bone | 100 IU once daily initially; maintenance often 50 IU daily or every other day, individualized to response | Subcutaneous (SC) or intramuscular (IM) injection |
| Hypercalcemia of malignancy | 4 IU/kg every 12 hours initially; may increase to 8 IU/kg every 12 hours after 1-2 days if response inadequate, and further to every 6 hours if needed | SC or IM injection |
| Postmenopausal osteoporosis | 200 IU (one spray) once daily, alternating nostrils; or 100 IU every other day by injection where injectable form is used for this indication | Intranasal spray (preferred) or SC/IM injection |
Adequate calcium and vitamin D intake should be ensured during treatment with Salmon Calcitonin as advised by the physician. Duration of use, especially for osteoporosis, should be kept as short as clinically appropriate (see Precautions).
Side Effects of Salmon Calcitonin
Common and important side effects of Salmon Calcitonin include:
- Nasal spray: Nasal irritation, rhinitis, nasal congestion, epistaxis (nosebleed), sinusitis, and other local nasal symptoms are common.
- Injection: Nausea (especially with initial doses, usually diminishing with continued use), flushing of the face and hands, injection-site reactions, and local inflammation.
- General: Headache, dizziness, urinary frequency, and rarely hypersensitivity reactions ranging from skin rash to (uncommonly) anaphylaxis.
- Tachyphylaxis: A gradual reduction in effectiveness may occur with prolonged use of Salmon Calcitonin.
Contraindications of Salmon Calcitonin
Salmon Calcitonin is contraindicated in patients with a known hypersensitivity to salmon calcitonin, salmon protein, or any component of the formulation, and in patients with hypocalcemia.
Frequently Asked Questions about Salmon Calcitonin
What is Salmon Calcitonin used for?
Salmon Calcitonin is used to treat Paget's disease of bone, to help lower high calcium levels caused by cancer (hypercalcemia of malignancy), and, in select patients who cannot use other treatments, for postmenopausal osteoporosis.
Can Salmon Calcitonin be used for long periods for osteoporosis?
Long-term use of Salmon Calcitonin for osteoporosis has been linked in some studies to a small increased risk of malignancy, so it is generally reserved for patients who cannot use other osteoporosis medicines, and duration of use should be limited and discussed with a physician.
How is Salmon Calcitonin given?
Salmon Calcitonin is given either as a nasal spray (one spray into alternating nostrils daily) or as a subcutaneous/intramuscular injection, depending on the indication and product; follow the physician's specific instructions.
What are the common side effects of Salmon Calcitonin?
Common side effects include nasal irritation, rhinitis, or nosebleeds with the nasal spray, and nausea, flushing, or injection-site reactions with the injectable form of Salmon Calcitonin. Allergic reactions, though uncommon, can occur since it is derived from salmon protein.
Is Salmon Calcitonin safe during pregnancy or breastfeeding?
Salmon Calcitonin should be used during pregnancy or breastfeeding only if clearly needed and if the potential benefit justifies the potential risk, after consulting a physician, since data in humans is limited.
What should I do if I miss a dose or take too much Salmon Calcitonin?
If a dose of Salmon Calcitonin is missed, take it as soon as remembered unless it is close to the next dose; do not double up. If an overdose is suspected, seek immediate medical attention or contact emergency/poison control services rather than treating it at home.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.