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Saxagliptin: Brands, Price & Uses in Bangladesh
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated for the following use: Established / FDA-approved use Type 2 diabetes mellitus (adults): Saxagliptin is indicated as an adjunct to…
About Saxagliptin
Indications of Saxagliptin
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated for the following use:
Established / FDA-approved use
- Type 2 diabetes mellitus (adults): Saxagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It may be used as monotherapy or in combination with other antidiabetic agents such as metformin, sulfonylureas, thiazolidinediones, or insulin, when these agents alone do not provide adequate glycemic control.
Not indicated for
- Type 1 diabetes mellitus.
- Treatment of diabetic ketoacidosis (should not be used for this purpose).
Saxagliptin is not a substitute for insulin in patients who require insulin therapy and should not be used to treat type 1 diabetes.
Dosage & Administration of Saxagliptin
Type 2 Diabetes Mellitus (Adults)
| Patient group | Recommended dose of Saxagliptin |
|---|---|
| Usual adult dose | 2.5 mg or 5 mg by mouth once daily |
| Mild renal impairment (eGFR/CrCl >50 mL/min) | No dose adjustment required |
| Moderate to severe renal impairment or end-stage renal disease (eGFR/CrCl ≤50 mL/min, including patients on hemodialysis) | 2.5 mg once daily; administer after hemodialysis, when applicable |
| Co-administration with strong CYP3A4/5 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) | Limit dose to 2.5 mg once daily |
| Hepatic impairment | No dose adjustment generally required in mild-to-moderate hepatic impairment; use with caution and clinical monitoring in severe hepatic impairment, as data are limited |
Saxagliptin is taken once daily by mouth, with or without food, at approximately the same time each day. Do not adjust the dose without medical advice.
Side Effects of Saxagliptin
Common side effects
- Upper respiratory tract infection, nasopharyngitis
- Headache
- Urinary tract infection
- Gastroenteritis, sinusitis
Less common but serious side effects
- Heart failure: increased risk of hospitalization for heart failure has been observed with Saxagliptin in cardiovascular outcomes studies. Seek medical attention for symptoms such as unusual shortness of breath, rapid weight gain, or swelling of the legs/ankles (see Precautions and Warnings).
- Acute pancreatitis: persistent, severe abdominal pain, sometimes radiating to the back, with or without vomiting.
- Hypersensitivity reactions: including anaphylaxis, angioedema, and exfoliative skin conditions (see Contraindications).
- Bullous pemphigoid: a blistering skin condition, reported with DPP-4 inhibitors including Saxagliptin.
- Severe and disabling joint pain (arthralgia).
- Hypoglycemia (mainly when combined with insulin or sulfonylureas).
- Lymphopenia (mild reduction in lymphocyte count).
Report any severe, persistent, or worsening symptoms to a physician promptly.
Contraindications of Saxagliptin
Saxagliptin is contraindicated in patients with a history of a serious hypersensitivity reaction to Saxagliptin or to any other DPP-4 inhibitor, including reactions such as anaphylaxis, angioedema, or exfoliative skin conditions (e.g., Stevens-Johnson syndrome).
Frequently Asked Questions about Saxagliptin
What is Saxagliptin used for?
Saxagliptin is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It is not used for type 1 diabetes or diabetic ketoacidosis.
How should I take Saxagliptin?
Saxagliptin is usually taken once daily by mouth, with or without food, at about the same time each day. Swallow the tablet whole and take it exactly as prescribed by your physician.
Can Saxagliptin cause low blood sugar (hypoglycemia)?
Saxagliptin alone has a low risk of causing hypoglycemia because its effect depends on blood glucose levels. However, the risk increases when Saxagliptin is combined with insulin or a sulfonylurea, and your doctor may lower the dose of those medicines.
Is Saxagliptin safe for the heart?
Some patients taking Saxagliptin have had an increased risk of hospitalization for heart failure. Tell your doctor right away if you notice unusual shortness of breath, rapid weight gain, or swelling of your legs or ankles while taking Saxagliptin.
Who should not take Saxagliptin?
Saxagliptin should not be used by anyone who has had a serious allergic reaction (such as anaphylaxis, severe swelling, or a severe skin reaction) to Saxagliptin or to any other DPP-4 inhibitor medicine.
Can I take Saxagliptin during pregnancy or while breastfeeding?
Saxagliptin should be used during pregnancy or breastfeeding only if your physician decides it is clearly needed, since safety data in these situations are limited. Uncontrolled diabetes during pregnancy also carries risks, so always consult your physician for individualized advice.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.