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Sevel800 mg
ACME Laboratories Ltd.
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Generic medicine
Sevelamer Carbonate: Brands, Price & Uses in Bangladesh
Sevelamer Carbonate is a non-calcium, non-absorbed phosphate-binding agent indicated for the control of serum phosphorus (hyperphosphatemia) in patients with chronic kidney disease (CKD).
About Sevelamer Carbonate
Indications of Sevelamer Carbonate
Sevelamer Carbonate is a non-calcium, non-absorbed phosphate-binding agent indicated for the control of serum phosphorus (hyperphosphatemia) in patients with chronic kidney disease (CKD).
- Established/labeled use: Control of serum phosphorus in adults and pediatric patients 6 years of age and older with CKD who are on dialysis (haemodialysis or peritoneal dialysis).
- Guideline-supported/regional use: In some markets, Sevelamer Carbonate is also indicated for control of serum phosphorus in adults with CKD not yet on dialysis, when serum phosphorus is significantly elevated, generally alongside dietary phosphate restriction.
- Adjunct role: Sevelamer Carbonate is typically used together with calcium supplementation and active vitamin D (or its analogues) as part of a comprehensive plan to manage CKD-mineral and bone disorder; it does not treat the underlying kidney disease itself.
Sevelamer Carbonate is not approved for patients without hyperphosphatemia or with normal renal function.
Dosage & Administration of Sevelamer Carbonate
Adults on Dialysis
| Baseline Serum Phosphorus | Starting Dose of Sevelamer Carbonate |
|---|---|
| 5.5-7.5 mg/dL (1.8-2.4 mmol/L) | 800 mg three times daily with meals |
| ≥7.5 mg/dL (≥2.4 mmol/L) | 1600 mg three times daily with meals |
The dose of Sevelamer Carbonate is then titrated upward or downward by 800 mg per meal at intervals of about 2 weeks, based on serum phosphorus levels, until an acceptable phosphorus level is reached. Average maintenance doses of approximately 6-7 grams per day (in divided doses with meals) are commonly used.
Patients Switching from Sevelamer Hydrochloride
Sevelamer Carbonate may be substituted for sevelamer hydrochloride on a gram-for-gram basis, with serum phosphorus monitored to confirm continued control.
Pediatric Patients (6 years and older, on dialysis)
| Body Surface Area (BSA) | Starting Dose of Sevelamer Carbonate |
|---|---|
| 0.75-1.2 m² | 800 mg per meal |
| >1.2 m² | 1600 mg per meal |
Doses of Sevelamer Carbonate are given three times daily with meals and titrated every 2 weeks initially, based on serum phosphorus response.
Administration Instructions
- Tablets of Sevelamer Carbonate must be swallowed whole; do not crush, chew, or split, as this alters how the medicine works in the gut.
- Always take Sevelamer Carbonate with meals (or immediately before/after eating); taking it without food substantially reduces its phosphate-binding effect.
- If a powder-for-suspension form of Sevelamer Carbonate is prescribed, mix the full contents of the packet with the recommended amount of water and take immediately with a meal.
Side Effects of Sevelamer Carbonate
The most common side effects of Sevelamer Carbonate seen in clinical trials are gastrointestinal and generally dose-related:
- Vomiting
- Nausea
- Diarrhea
- Dyspepsia (indigestion)
- Abdominal pain
- Flatulence
- Constipation
Less common but more serious gastrointestinal events have been reported with Sevelamer Carbonate and other phosphate-binder resins, including dysphagia, tablet retention in the esophagus, bowel obstruction, bleeding, ulceration, perforation, and colitis; some cases required hospitalization or surgery. Seek prompt medical attention for severe abdominal pain, persistent vomiting, or inability to pass stool or gas while taking Sevelamer Carbonate.
Hypersensitivity reactions such as rash and pruritus have been reported post-marketing with Sevelamer Carbonate.
Contraindications of Sevelamer Carbonate
Sevelamer Carbonate is contraindicated in:
- Patients with known hypersensitivity to sevelamer carbonate, sevelamer hydrochloride, or any component of the formulation.
- Patients with bowel obstruction.
Frequently Asked Questions about Sevelamer Carbonate
Why do I need to take Sevelamer Carbonate with every meal?
Sevelamer Carbonate works by binding to phosphate from the food you eat while it is in your stomach and intestines. If you take it without food, there is little or no phosphate for it to bind, so it will not effectively lower your blood phosphorus level. Always take Sevelamer Carbonate with a meal or right before/after eating.
Can I crush or chew the Sevelamer Carbonate tablets?
No. Tablets of Sevelamer Carbonate should be swallowed whole. Crushing, chewing, or splitting the tablet can change how it works in the gut and is not recommended unless your physician or pharmacist specifically advises otherwise.
What should I do if I miss a dose of Sevelamer Carbonate?
Since Sevelamer Carbonate only works when taken with food, if you miss a dose simply skip it and take your next dose with your next meal as scheduled. Do not take a double dose to make up for the missed one.
Can Sevelamer Carbonate be taken during pregnancy or breastfeeding?
Sevelamer Carbonate is not absorbed into the bloodstream, so direct exposure of the baby is not expected, but safety data in pregnant and breastfeeding women are limited. Sevelamer Carbonate should be used in pregnancy only if clearly needed, when the benefit outweighs the potential risk, and only under a physician's guidance; the same caution applies during breastfeeding. Because Sevelamer Carbonate can lower absorption of fat-soluble vitamins and folic acid, your physician may recommend supplements.
What are the most common side effects of Sevelamer Carbonate?
The most common side effects of Sevelamer Carbonate are gastrointestinal: nausea, vomiting, diarrhea, indigestion, abdominal pain, gas, and constipation. These are usually dose-related. Rarely, more serious problems such as difficulty swallowing, tablets getting stuck in the esophagus, or bowel obstruction have been reported; seek prompt medical care for severe abdominal pain, persistent vomiting, or inability to pass stool or gas.
Can I take my other medicines at the same time as Sevelamer Carbonate?
Sevelamer Carbonate can bind to certain oral medicines in the gut and reduce how much of them your body absorbs. For example, ciprofloxacin should be taken at least 2 hours before or 6 hours after Sevelamer Carbonate, and mycophenolate mofetil at least 2 hours before it. For other important medicines, it is generally safest to take them 1 hour before or 3 hours after Sevelamer Carbonate unless your physician tells you separation is not needed. Always tell your physician or pharmacist about all medicines you take alongside Sevelamer Carbonate.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.