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Silodosin: Brands, Price & Uses in Bangladesh
Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men.
About Silodosin
Indications of Silodosin
Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men. It is FDA-approved and guideline-supported (used per AUA/EAU BPH management guidelines) as a first-line alpha-1 adrenergic receptor antagonist for relieving lower urinary tract symptoms (LUTS) associated with BPH, such as weak urine stream, urinary hesitancy, straining, incomplete bladder emptying, frequency, and nocturia.
- Established use: Symptomatic relief of BPH in men (monotherapy).
- Not indicated for the treatment of hypertension or for use in women or children.
Silodosin is not a cure for BPH and does not reduce prostate size; it works by relaxing smooth muscle to improve urine flow.
Dosage & Administration of Silodosin
The dose of Silodosin should be individualized based on renal function; it is not indicated for use in women or children.
| Indication / Population | Recommended dose of Silodosin |
|---|---|
| Adult men with BPH (normal to mild renal impairment, CrCl ≥50 mL/min) | 8 mg orally once daily, with a meal, at approximately the same time each day |
| Moderate renal impairment (CrCl 30-49 mL/min) | 4 mg orally once daily, with a meal |
| Severe renal impairment (CrCl <30 mL/min) | Contraindicated - see Contraindications |
| Severe hepatic impairment | Contraindicated - see Contraindications |
| Women and children | Not indicated; safety and efficacy not established |
If therapy is interrupted for several days, treatment should be resumed at the original recommended dose. Silodosin capsules should be swallowed whole; if a patient has difficulty swallowing, the capsule may be opened and the contents sprinkled on a tablespoon of applesauce and consumed immediately without chewing.
Side Effects of Silodosin
The most common adverse effect of Silodosin is retrograde ejaculation, occurring in a substantial proportion of men treated. Other side effects are generally mild to moderate.
- Very common: Retrograde ejaculation (reduced or absent semen volume during orgasm).
- Common: Dizziness, diarrhea, orthostatic hypotension, headache, nasal congestion/nasopharyngitis.
- Less common: Fainting (syncope), palpitations, rhinorrhea, abnormal ejaculation/anejaculation.
Most sexual side effects, including retrograde ejaculation, are reversible upon discontinuing Silodosin.
Contraindications of Silodosin
Silodosin is contraindicated in:
- Patients with known hypersensitivity to Silodosin or any component of the formulation.
- Patients with severe renal impairment (creatinine clearance <30 mL/min).
- Patients with severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, ritonavir), due to markedly increased Silodosin plasma concentrations.
Frequently Asked Questions about Silodosin
What is Silodosin used for?
Silodosin is used to relieve the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men, such as weak urinary stream, urgency, hesitancy, and incomplete bladder emptying. It is not used to treat high blood pressure and is not approved for use in women.
How should I take Silodosin?
Silodosin should be taken by mouth once daily, with a meal, at about the same time each day. The usual dose is 8 mg daily, or 4 mg daily if you have moderate kidney impairment. Swallow the capsule whole, or if needed, open it and sprinkle the contents on applesauce and swallow immediately without chewing.
What are the most common side effects of Silodosin?
The most common side effect of Silodosin is retrograde ejaculation (reduced or absent semen during orgasm), which is harmless and reversible after stopping the medicine. Other common effects include dizziness, diarrhea, low blood pressure on standing, headache, and nasal congestion.
Can Silodosin cause low blood pressure or fainting?
Yes. Silodosin can cause orthostatic hypotension, especially with the first few doses, leading to dizziness or, rarely, fainting when standing up quickly. Rise slowly from sitting or lying positions and avoid driving or operating machinery until you know how Silodosin affects you.
Do I need to tell my eye surgeon that I take Silodosin?
Yes. If you are scheduled for cataract surgery, you must inform your ophthalmologist that you are taking or have taken Silodosin, because it can cause Intraoperative Floppy Iris Syndrome (IFIS), which may require the surgeon to adjust their technique. Do not stop Silodosin on your own before surgery without your doctor's advice.
Who should not take Silodosin?
Silodosin should not be taken by anyone with a known allergy to it, patients with severe kidney or liver impairment, or those taking strong CYP3A4-inhibiting medicines such as ketoconazole, itraconazole, clarithromycin, or ritonavir, because these combinations significantly increase the risk of serious side effects. Silodosin is not for use in women or children.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.