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Actrim(200 mg+40
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Medicine overview
Indications of Biotrim (200 mg+40 mg)/5 ml
Biotrim (200 mg+40 mg)/5 ml is bactericidal in vitro to a wide range of Gram-positive and Gram-negative organisms, including Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Brucella, Pneumocystis carinii, Nocardia and Bordetella. A particularly high degree of activity is exhibited against Haemophilus influenzae, E. coli and Proteus spp., making Biotrim (200 mg+40 mg)/5 ml particularly suitable for the treatment of chronic bronchitis and urinary tract infections. Biotrim (200 mg+40 mg)/5 ml exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of Folinic acid in the micro-organisms. The synergy thus produced accounts for the high degree of bactericidal activity.Indications are :
Respiratory tract infections, including acute and chronic bronchitis (treatment and prophylaxis), bronchiectasis, lung abscess, lobar and broncho-pneumonia, Pneumocystis carinii pneumonitis, sinusitis and otitis media.
Genito-urinary tract infections, including urethritis, acute and chronic cystitis, pyelonephritis, prostatitis and gonorrhoea.
Gastro-intestinal tract infections, caused by Salmonella typhi and Salmonella paratyphi, including the chronic carrier state.
Other infections, caused by a wide range of organisms confirmed to be susceptible to Biotrim (200 mg+40 mg)/5 ml and where the therapeutic benefits are considered to outweigh the possible occurrence of adverse events.
Such infections include acute and chronic osteomyelitis, acute brucellosis, skin infections including pyoderma, abscesses and wound infections, septicaemia, bacillary dysentery and cholera (as an adjuvant to fluid and electrolyte replacement), nocardiosis and mycetoma.
Theropeutic Class
Anti-diarrhoeal Antimicrobial drugs, Sulphonamides & Trimethoprim
Pharmacology
Biotrim (200 mg+40 mg)/5 ml having broad spectrum bactericidal activity against a wide range of gram-positive & gram-negative bacteria and some protozoa. Co-trimoxazole containing Trimethoprim and Sulphamethoxazole in a 1:5 combination exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in the microorganism.
Dosage & Administration of Biotrim (200 mg+40 mg)/5 ml
Biotrim (200 mg+40 mg)/5 ml double strength tablet: Over 12 years
For mild to moderate infections: 1 tablet twice daily.
For severe infections: 1.5 tablets twice daily.
Long term therapy (>14 days): 0.5 tablet twice daily.
Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours.
Biotrim (200 mg+40 mg)/5 ml tablet: over 12 years
For mild to moderate infections: 2 tablets twice daily.
For severe infections: 2 tablets thrice daily.
Long term therapy: (>14 days): 1 tablet twice daily.
Biotrim (200 mg+40 mg)/5 ml suspension: Under 12 years
6-12 years: 2 teaspoonful twice daily.
6 month-5 years: 1 teaspoonful twice daily.
6 weeks-6 months: 0.5 teaspoonful twice daily.
Contraindications
Hypersensitivity to trimethoprim or sulphonamides.
Patients with documented megaloblastic anaemia due to folate deficiency.
Patients showing marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency.
Side Effects of Biotrim (200 mg+40 mg)/5 ml
The side effects like crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been reported rarely with Sulphamethoxazole-Trimethoprim combination. Other side effects are less serious in nature such as malaise, headache, nausea and vomiting. These are normally transient and do not require withdrawal of treatment.
Pregnancy & Lactation
Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.
Precautions & Warnings
Prolonged full dose treatment with sulfamethoxazole-trimethoprim combination is associated with the risk of macrocytic anaemia due to the drug’s interference in the conversion of Folic acid into Folinic acid. If this occurs, it can be reversed by giving Folinic acid. Care should be taken when giving this combination to diabetic patients receiving sulphonylurea drug for possible potentiation of action of sulphonylurea.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Frequently Asked Questions
What is Biotrim (200 mg+40 mg)/5 ml used for?
Biotrim (200 mg+40 mg)/5 ml is bactericidal in vitro to a wide range of Gram-positive and Gram-negative organisms, including Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Brucella, Pneumocystis carinii, Nocardia and Bordetella. A particularly high degree of activity is exhibite…
What is the dosage of Biotrim (200 mg+40 mg)/5 ml?
Biotrim (200 mg+40 mg)/5 ml double strength tablet: Over 12 years For mild to moderate infections: 1 tablet twice daily. For severe infections: 1.5 tablets twice daily. Long term therapy (>14 days): 0.5 tablet twice daily. Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours. Biotrim (200 mg+40 mg)/5 ml tablet: over 12 years For m…
What are the side effects of Biotrim (200 mg+40 mg)/5 ml?
The side effects like crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been reported rarely with Sulphamethoxazole-Trimethoprim combination. Other side effects are less serious in nature such as malaise, headache, nausea and vomiting. These are normally transient and do not require withdrawal of treatment.
Who should not take Biotrim (200 mg+40 mg)/5 ml?
Hypersensitivity to trimethoprim or sulphonamides. Patients with documented megaloblastic anaemia due to folate deficiency. Patients showing marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency.
What precautions should be taken with Biotrim (200 mg+40 mg)/5 ml?
Prolonged full dose treatment with sulfamethoxazole-trimethoprim combination is associated with the risk of macrocytic anaemia due to the drug’s interference in the conversion of Folic acid into Folinic acid. If this occurs, it can be reversed by giving Folinic acid. Care should be taken when giving this combination to diabetic patients receiving sulphonylurea drug for possible potentiation of act…
Is Biotrim (200 mg+40 mg)/5 ml safe during pregnancy and breastfeeding?
Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.