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Bisoren M

Bisoren M5 mg+5 mg

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Medicine overview

Indications of Bisoren M 5 mg+5 mg

Bisoprolol & Amlodipine combination is indicated for the treatment of hypertension as substitution therapy in patients adequately controlled with the individual products given concurrently at the same doses level as in the combination, but as separate tablets.

Theropeutic Class

Anti-hypertensive

Pharmacology

Bisoprolol and Amlodipine combination increases the antihypertensive and anti-anginal efficacy by complementary mechanism of actions of the two active compounds: Vasoselective effect of the Amlodipine (decrease of peripheral resistance) and cardio-selective β-blocker Bisoprolol (decrease of cardiac output).

Dosage & Administration of Bisoren M 5 mg+5 mg

The recommended daily dose is one tablet with or without food. The dose may be increased if the desired therapeutic effect is not achieved.

Interaction of Bisoren M 5 mg+5 mg

Centrally Acting Antihypertensive Drugs (e.g. Clonidine, Methyldopa, Moxonidine, Rilmenidine): Concomitant use of these drugs with Bisoprolol may lead to reduction of heart rate and cardiac output, as well as to vasodilation. CYP3A4 Inhibitors: Concomitant use of Amlodipine with strong or moderate inhibitors of CYP3A4 (e.g. protease inhibitors, azole antifungals, macrolides like Erythromycin or Clarithromycin, Verapamil or Diltiazem) can be expected to increase the plasma concentrations of Amlodipine to a clinically relevant extent. Anesthetic Agents: In combination with Bisoprolol, reflex tachycardia may be attenuated and the risk of hypotension may be increased. Cardiac glycosides (Digitalis): Concomitant use with Bisoprolol may lead to a reduction of heart rate or an increase of atrio-ventricular conduction time.

Contraindications

Bisoprolol & Amlodipine combination is contraindicated in patients with acute heart failure, high grade aortic stenosis, cardiogenic shock, second or third degree AV block, sick sinus syndrome, slowed heart rate, symptomatic bradycardia, symptomatic hypotension, bronchial asthma and hypersensitivity to Bisoprolol, Amlodipine or any of the excipients.

Side Effects of Bisoren M 5 mg+5 mg

Headache, drowsiness, dizziness, bradycardia.

Pregnancy & Lactation

Pregnancy: Bisoprolol & Amlodipine combination is not recommended during pregnancy unless clearly necessary. Nursing mothers: It is not known whether Bisoprolol or Amlodipine is excreted in human milk.

Overdose Effects of Bisoren M 5 mg+5 mg

The most common signs expected with overdose of Bisoprolol & Amlodipine are bradycardia, hypotension, bronchospasm, peripheral vasodilatation and reflex tachycardia.

Storage Conditions

Store below 30° C, protects from light & moisture. Keep out of the reach of children

Use In Special Populations

Children: Safety and effectiveness in paediatric patients have not been established. Geriatric Patients: No dosage adjustment is required. However, caution is advised when the dose is increased.

Frequently Asked Questions

What is Bisoren M 5 mg+5 mg used for?

Bisoprolol & Amlodipine combination is indicated for the treatment of hypertension as substitution therapy in patients adequately controlled with the individual products given concurrently at the same doses level as in the combination, but as separate tablets.

What is the dosage of Bisoren M 5 mg+5 mg?

The recommended daily dose is one tablet with or without food. The dose may be increased if the desired therapeutic effect is not achieved.

What are the side effects of Bisoren M 5 mg+5 mg?

Headache, drowsiness, dizziness, bradycardia.

Who should not take Bisoren M 5 mg+5 mg?

Bisoprolol & Amlodipine combination is contraindicated in patients with acute heart failure, high grade aortic stenosis, cardiogenic shock, second or third degree AV block, sick sinus syndrome, slowed heart rate, symptomatic bradycardia, symptomatic hypotension, bronchial asthma and hypersensitivity to Bisoprolol, Amlodipine or any of the excipients.

Is Bisoren M 5 mg+5 mg safe during pregnancy and breastfeeding?

Pregnancy: Bisoprolol & Amlodipine combination is not recommended during pregnancy unless clearly necessary. Nursing mothers: It is not known whether Bisoprolol or Amlodipine is excreted in human milk.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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