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Brodil4 mg
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Medicine overview
Indications of Brodil 4 mg
Brodil 4 mg is indicated as a bronchodilator for use in-
Asthma
Chronic Bronchitis
Emphysema and
Other conditions associated with airways obstruction.
Theropeutic Class
Short-acting selective & β2-adrenoceptor stimulants
Pharmacology
Brodil 4 mg is a selective beta2-adrenoceptor agonist.
Absorption
At therapeutic doses, it acts on the beta 2-adrenoceptors of bronchial smooth muscle, with little or no action on the ß1-adrenoceptors of cardiac muscle.
Distribution
Brodil 4 mg provides short acting (4-6 hours) bronchodilatation with a fast onset (within 5 minutes) in reversible airways obstruction.
Metabolism
It also has an anti-inflammatory effect on mast cells causing inhibition of release of bronchoconstrictor mediators including histamine, neutrophil chemotactive factor (NCF) and prostaglandin D2.
Dosage & Administration of Brodil 4 mg
Oral- Children
Dosage:2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily
Notes:Maximum single dose is 8 mg tablet. Injection- Brodil 4 mg Injection may be administered by the subcutaneous, intramuscular or intravenous route, under the direction of a physician
Adults
Dosage:Subcutaneous route: 500 mcg (8 mcg/kg) and repeated every four hours as required
Intramuscular route
Dosage:500 mcg (8 mcg/kg) and repeated every four hours as required
Slow intravenous injection
Dosage:250 mcg (4 mcg/kg) injected slowly
Notes:If necessary the dose may be repeated. The use of Brodil 4 mg Injection 500 mcg in 1 ml (500 mcg/ml, for intravenenous administration may be facilitated by dilution to 10 ml with Water for Injection BP (final concentration of 50 mcg/ml) and 5 ml of the diluted preparation (250 mcg/5 ml) administered by slow intravenous injection
Pediatric Population
Dosage:The safety and efficacy of Brodil 4 mg Injection in children under the age of 12 has not been established
Notes:From the available data no recommendation on posology can be made
Children aged 12 years and over
Dosage:Dose as per adult population
| Condition | Dosage | Notes |
|---|---|---|
| Oral- Children | 2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily | Maximum single dose is 8 mg tablet. Injection- Brodil 4 mg Injection may be administered by the subcutaneous, intramuscular or intravenous route, under the direction of a physician |
| Adults | Subcutaneous route: 500 mcg (8 mcg/kg) and repeated every four hours as required | |
| Intramuscular route | 500 mcg (8 mcg/kg) and repeated every four hours as required | |
| Slow intravenous injection | 250 mcg (4 mcg/kg) injected slowly | If necessary the dose may be repeated. The use of Brodil 4 mg Injection 500 mcg in 1 ml (500 mcg/ml, for intravenenous administration may be facilitated by dilution to 10 ml with Water for Injection BP (final concentration of 50 mcg/ml) and 5 ml of the diluted preparation (250 mcg/5 ml) administered by slow intravenous injection |
| Pediatric Population | The safety and efficacy of Brodil 4 mg Injection in children under the age of 12 has not been established | From the available data no recommendation on posology can be made |
| Children aged 12 years and over | Dose as per adult population |
Dosage of Brodil 4 mg
Brodil 4 mg tablet or syrup-Children
Dosage:2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily
Notes:Maximum single dose is 8 mg tablet
Brodil 4 mg Respirator Solution
Dosage:To be used with a suitable nebulizer device under the direction of a physician
Notes:The solution must not be injected or ingested
Method-1 (Intermittent Administration)
Dosage:Adults (and the elderly): 0.5 ml-1.0 ml Brodil 4 mg up to four times a day
Notes:Up to 40mg per day can be given under strict medical direction in the hospital. 0.5-1 ml solution should be diluted to final volume of 2-4 ml with sterile normal saline solution. It will take time about 10 minutes. Brodil 4 mg respiratory solution may be used undiluted for intermittent administration. For this 2.0 ml of the solution is placed in the nebulizer and the patient allowed to inhale until bronchodilation is achieved. This usually takes 3-5 minutes
Children under 12 years of age
Dosage:0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline
Notes:Some children may however require higher doses of up to 1.0 ml of the solution. Intermittent treatment may be repeated four times a day
Method-2 (Continuous administration)
Dosage:1-2 ml solution is diluted to make up to 100 ml with normal saline solution
Notes:The diluted solution is administered by a suitable nebulizer devise. When there is risk of anoxia through hypoventilation, oxygen should be added to the inspired air
Brodil 4 mg nebulizer solution
Dosage:To be used with a suitable nebulizer device under the direction of a physician
Notes:The solution must not be injected or ingested
Adults & Elderly
Dosage:2.5 mg to 5 mg Brodil 4 mg up to 4 times a day
Notes:Up to 40 mg/day may be given under strict medical direction in the hospital
Children under 12 years
Dosage:2.5 mg up to 4 times a day
Notes:A higher dose up to 5 mg four times a day may be used if required
Brodil 4 mg injection
Dosage:Adults: Brodil 4 mg I
Notes:infusion solution is used to prepare a solution for continuous intravenous infusion. It should not be injected undiluted. A suitable solution for infusion may be prepared by diluting 5 mL of Brodil 4 mg I. infusion solution (1000 mcg/mL) in 500 mL of a chosen i. solution to provide a Brodil 4 mg concentration of 10 mcg/mL. The only recommended diluents are Sodium Chloride Injection, or Sodium Chloride and Dextrose Injection. Infusion rates providing 3 to 20 micrograms Brodil 4 mg/minute (0.3 to 2ml/minute of the above infusion solution) are usually adequate. Infusion rates can be started at 5 mcg of Brodil 4 mg/min. , and can be increased to 10 mcg/min. , and 20 mcg/min. at 15 - 30 minute intervals, if necessary. As with all parenteral drug products, intravenous admixtures should be inspected visually for clarity, particulate matter, precipitate, discoloration and leakage prior to administration. All unused admixtures of Brodil 4 mg infusion solution with infusion fluids should be discarded 24 hours after preparation
Children and Adolescents (<18 years of age)
Dosage:The dosage of Brodil 4 mg infusion solution in the pediatric age group has not been established
Notes:At present, there are insufficient data to recommend a dosage regimen for children
Brodil 4 mg Inhalation Capsule
Dosage:Adults: For the relief of bronchospasm and for managing intermittent episodes of asthma, one or two inhalation capsule may be administered as a single dose
Notes:The usual recommended dosage of Brodil 4 mg inhalation capsule for inhalation for adults for maintenance or prophylactic therapy is the contents of one 200 microgram capsule every 4 to 6 hours using a device. In some patients, the contents of two 200 microgram capsules inhaled every 4 to 6 hours may be required. Large doses or more frequent administration is not recommended. The use of Brodil 4 mg powder for inhalation can be continued as medically indicated to control recurring/intermittent episodes of bronchospasm
Children
Dosage:One Brodil 4 mg inhalation capsule is the recommended dose for relief of acute bronchospasm in the maintenance of episodic asthma or before exercise of children 4 years of age and older
Notes:One inhalation should be administered for three or four times a day for routine maintenance or prophylactic therapy. This dosage may be increased to inhalation of two inhalation capsule, if necessary. The bronchodilator effect of each administration of inhaled Brodil 4 mg inhalation capsule lasts for at least four hours. Such patients should be warned not to increase the dose of inhaler, but should seek medical advice immediately
Excercise-induced Asthma
Dosage:Adults: 400 microgram Child: 200 microgram, 15-30 minutes prior to any physical exertion
| Condition | Dosage | Notes |
|---|---|---|
| Brodil 4 mg tablet or syrup-Children | 2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily | Maximum single dose is 8 mg tablet |
| Brodil 4 mg Respirator Solution | To be used with a suitable nebulizer device under the direction of a physician | The solution must not be injected or ingested |
| Method-1 (Intermittent Administration) | Adults (and the elderly): 0.5 ml-1.0 ml Brodil 4 mg up to four times a day | Up to 40mg per day can be given under strict medical direction in the hospital. 0.5-1 ml solution should be diluted to final volume of 2-4 ml with sterile normal saline solution. It will take time about 10 minutes. Brodil 4 mg respiratory solution may be used undiluted for intermittent administration. For this 2.0 ml of the solution is placed in the nebulizer and the patient allowed to inhale until bronchodilation is achieved. This usually takes 3-5 minutes |
| Children under 12 years of age | 0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline | Some children may however require higher doses of up to 1.0 ml of the solution. Intermittent treatment may be repeated four times a day |
| Method-2 (Continuous administration) | 1-2 ml solution is diluted to make up to 100 ml with normal saline solution | The diluted solution is administered by a suitable nebulizer devise. When there is risk of anoxia through hypoventilation, oxygen should be added to the inspired air |
| Brodil 4 mg nebulizer solution | To be used with a suitable nebulizer device under the direction of a physician | The solution must not be injected or ingested |
| Adults & Elderly | 2.5 mg to 5 mg Brodil 4 mg up to 4 times a day | Up to 40 mg/day may be given under strict medical direction in the hospital |
| Children under 12 years | 2.5 mg up to 4 times a day | A higher dose up to 5 mg four times a day may be used if required |
| Brodil 4 mg injection | Adults: Brodil 4 mg I | infusion solution is used to prepare a solution for continuous intravenous infusion. It should not be injected undiluted. A suitable solution for infusion may be prepared by diluting 5 mL of Brodil 4 mg I. infusion solution (1000 mcg/mL) in 500 mL of a chosen i. solution to provide a Brodil 4 mg concentration of 10 mcg/mL. The only recommended diluents are Sodium Chloride Injection, or Sodium Chloride and Dextrose Injection. Infusion rates providing 3 to 20 micrograms Brodil 4 mg/minute (0.3 to 2ml/minute of the above infusion solution) are usually adequate. Infusion rates can be started at 5 mcg of Brodil 4 mg/min. , and can be increased to 10 mcg/min. , and 20 mcg/min. at 15 - 30 minute intervals, if necessary. As with all parenteral drug products, intravenous admixtures should be inspected visually for clarity, particulate matter, precipitate, discoloration and leakage prior to administration. All unused admixtures of Brodil 4 mg infusion solution with infusion fluids should be discarded 24 hours after preparation |
| Children and Adolescents (<18 years of age) | The dosage of Brodil 4 mg infusion solution in the pediatric age group has not been established | At present, there are insufficient data to recommend a dosage regimen for children |
| Brodil 4 mg Inhalation Capsule | Adults: For the relief of bronchospasm and for managing intermittent episodes of asthma, one or two inhalation capsule may be administered as a single dose | The usual recommended dosage of Brodil 4 mg inhalation capsule for inhalation for adults for maintenance or prophylactic therapy is the contents of one 200 microgram capsule every 4 to 6 hours using a device. In some patients, the contents of two 200 microgram capsules inhaled every 4 to 6 hours may be required. Large doses or more frequent administration is not recommended. The use of Brodil 4 mg powder for inhalation can be continued as medically indicated to control recurring/intermittent episodes of bronchospasm |
| Children | One Brodil 4 mg inhalation capsule is the recommended dose for relief of acute bronchospasm in the maintenance of episodic asthma or before exercise of children 4 years of age and older | One inhalation should be administered for three or four times a day for routine maintenance or prophylactic therapy. This dosage may be increased to inhalation of two inhalation capsule, if necessary. The bronchodilator effect of each administration of inhaled Brodil 4 mg inhalation capsule lasts for at least four hours. Such patients should be warned not to increase the dose of inhaler, but should seek medical advice immediately |
| Excercise-induced Asthma | Adults: 400 microgram Child: 200 microgram, 15-30 minutes prior to any physical exertion |
Contraindications
Brodil 4 mg is contraindicated in patients with a history of hypersensitivity to Brodil 4 mg or any of its components.
Side Effects of Brodil 4 mg
Brodil 4 mg may cause fine tremor of skeletal muscles (particularly the hands), palpitations and muscle cramps. Tachycardia, tenseness, headaches and peripheral vasodilatation have been reported after large doses.
Pregnancy & Lactation
Pregnancy: The drug should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus. Lactation: It is not known whether this drug is excreted in human milk. Because of the potential of tumorigenecity shown for Brodil 4 mg in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Precautions & Warnings
Brodil 4 mg should be used with caution in patients with hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension and aneurysms. Hypokalaemia associated with high doses of Brodil 4 mg may result in increased susceptibility to digitalis-induced cardiac arrhythmia. Tachyphylaxis with resistance may occur with prolonged use of high dosage. Care is necessary when treating patients with diabetes mellitus or closed angle glaucoma, and in those receiving antihypertensive therapy.
Overdose Effects of Brodil 4 mg
The symptoms with overdosage are angina, headache, nausea, vomiting, tremor etc. The preferred antidote for overdosage with Brodil 4 mg is a cardio-selective beta-blocking agent but beta-blocking drugs should be used with caution in patients with a history of bronchospasm.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Short-acting selective & β2-adrenoceptor stimulants
Mode Of Action
Brodil 4 mg is a synthetic sympathomimetic agent with predominant beta-2 adrenergic activity. Brodil 4 mg produces bronchodilatation through stimulation of beta-2-adrenergic receptors in bronchial smooth muscles, thereby causing relaxation of bronchial muscle fibers. This action is manifested by an improvement in pulmonary function as demonstrated by spirometric measurements.
Pregnancy
The drug should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus. It is not known whether this drug is excreted in human milk. Because of the potential of tumorigenecity shown for Brodil 4 mg in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
What is Brodil 4 mg used for?
Salbutamol is indicated as a bronchodilator for use in- Asthma Chronic Bronchitis Emphysema and Other conditions associated with airways obstruction.
What is the dosage of Brodil 4 mg?
Salbutamol tablet or syrup-Children: 2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily. Maximum single dose is 8 mg tablet.Salbutamol Respirator Solution: To be used with a suitable nebulizer device under the direction of a physician. The solution mus…
What are the side effects of Brodil 4 mg?
Salbutamol may cause fine tremor of skeletal muscles (particularly the hands), palpitations and muscle cramps. Tachycardia, tenseness, headaches and peripheral vasodilatation have been reported after large doses.
Who should not take Brodil 4 mg?
Salbutamol is contraindicated in patients with a history of hypersensitivity to Salbutamol or any of its components.
What precautions should be taken with Brodil 4 mg?
Salbutamol should be used with caution in patients with hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension and aneurysms. Hypokalaemia associated with high doses of Salbutamol may result in increased susceptibility to digitalis-induced cardiac arrhythmia. Tachyphylaxis with resistance may occur with prolonged use of high dosage. Care is necessary when treating pati…
Is Brodil 4 mg safe during pregnancy and breastfeeding?
Pregnancy: The drug should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus. Lactation: It is not known whether this drug is excreted in human milk. Because of the potential of tumorigenecity shown for Salbutamol in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the import…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.