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Medicine overview
Indications of Candoral 2% w/w
It is indicated in the treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract.
Theropeutic Class
Aural Anti-fungal preparations
Pharmacology
Miconazole is a synthetic broad spectrum anti-fungal agent and acts against pathogenic fungi including yeast and dermatophytes and gram-positive bacteria (Staphylococcus and Streptococcus spp). It acts by inhibiting membrane sterol synthesis and interfering with the permeability of the fungal cell membranes.
Dosage of Candoral 2% w/w
Oropharyngeal candidosis-
Infants 4-24 month: 1.25 ml (1/4 measuring spoon) of gel, applied 4 times day after meals.
Adult and children 2 years of age and older: 2.5 ml (1/2 measuring spoon) of gel, applied 4 times a day after meals.
Gastrointestinal tract candidosis-
Infants (4 month of age or above), children and adults who have difficulty swallowing tablets: 20 mg per kg body weight per day, in four divided doses. The daily dose should not exceed 250 mg (10 ml gel) four times day.
Administration of Candoral 2% w/w
In case of localized lesions of the mouth, a small amount of gel may be applied 2-4 times a day directly to the affected area with a clean finger. For best results, Miconazole oral gel should be kept in contact with the affected area as long as possible. The treatment should be continued for at least a week after symptoms have disappeared. For oral candidosis, dental prosthesis should be removed at night and brushed with the gel.
Interaction of Candoral 2% w/w
Miconazole can inhibit the metabolism of drugs metabolized by the cytochrome P450-3A and P450-2C9. Miconazole oral gel should not be used during treatment with cisapride, trizolam, oral midazolam, mizolastine, quinidine, simvastatin and lovastatin.
Contraindications
Miconazole is contraindicated in patients with known hypersensitivity to the active ingredient.
Side Effects of Candoral 2% w/w
Occasionally nausea and vomiting, diarrhea with long term use and rarely allergic reactions.
Pregnancy & Lactation
There is no information regarding the safety of Miconazole oral gel during pregnancy. So Miconazole oral gel should be avoided in pregnant women if possible or the potential hazards should be balanced against the possible benefits. As many drugs are excreted in human milk, caution should be exercised when Miconazole is administered to a nursing woman.
Precautions & Warnings
If the concomitant use of Miconazole and anticoagulant is considered, the anti-coagulant effect should be monitored and titrated. Miconazole and phenytoin plasma level should also be monitored when used concomitantly. In infants and young children, caution must be taken to ensure that the gel does not obstruct the throat.
Storage Conditions
keep in a dry place away from light and heat. Keep out of the reach of children.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.