Clix

Clix500 mg

Clarithromycin

Eskayef Bangladesh Ltd.

Product Code : 3783
MRP 40.00
10% Off
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Section

Medicine overview

Indications of Clix 500 mg

Clix 500 mg is indicated in- Streptococcal pharyngitis Sinusitis Infective exacerbations of chronic bronchitis Community-acquired pneumonia Atypical pneumonia Skin and soft tissue infection Adjunct in the treatment of duodenal ulcers by eradication of H.pylori.

Theropeutic Class

Macrolides

Pharmacology

Clix 500 mg acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S sub- unit of the bacterial ribosome and preventing translocation to that site. Clix 500 mg is active against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas. Clix 500 mg’s activity is the same as, or greater than, that of erythromycin in vitro against most Gram-positive bacteria. Clix 500 mg is more acid stable than erythromycin and therefore, is better tolerated. Clix 500 mg has twice the activity of erythromycin against H. influenzae. Most species of Gram-negative bacteria are resistant to Clix 500 mg because of failure to penetrate to the target.

Dosage of Clix 500 mg

Adults: Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days. Acute maxillary sinusitis 500 mg every 12 hours for 14 days. Chronic bronchitis 250-500 mg every 12 hours for 7-14 days. Pneumonia 250 mg every 12 hours for 7-14 days. Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days. Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days. Children: Bodyweight under 8 kg: 7.5 mg/kg twice daily. Bodyweight of 8-11 kg (1-2 years): 2.5 ml (Half teaspoonful) twice daily. Bodyweight of 12-19 kg (3-6 years): 5 ml (One teaspoonful) twice daily. Bodyweight of 20-29 kg (7-9 years): 7.5 ml (One & half teaspoonfuls) twice daily. Bodyweight of 30-40 kg (10-12 years): 10 ml (Two teaspoonfuls) twice daily.

Administration of Clix 500 mg

Clix 500 mg may be given with or without meals.

Interaction of Clix 500 mg

Theophylline: Concomitant use of Clix 500 mg who are receiving Theophylline may be associated with an increase in serum Theophylline concentrations. Terfenadine: Clix 500 mg may alter the metabolism of Terfenadine.

Contraindications

Hypersensitivity to Clix 500 mg, Erythromycin, or any of the macrolide antibiotics. Patients receiving Terfenadine who have pre-existing cardiac abnormalities or electrolyte disturbances.

Side Effects of Clix 500 mg

Clix 500 mg is generally well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Stomatitis and glossitis have also been reported. Other side effects include headache, allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis. Taste perversion may occur. There have been reports of transient central nervous system side effects including anxiety, dizziness, insomnia and hallucination.

Pregnancy & Lactation

Clix 500 mg is not recommended for pregnant women. Breast milk from mothers receiving Clix 500 mg should not be given to infants until treatment is completed.

Precautions & Warnings

Clix 500 mg is principally excreted by the liver and kidney. Caution should be taken in administering this antibiotic to patients with impaired hepatic and renal function. Prolonged or repeated use of Clix 500 mg may result in an overgrowth of non-susceptible bacteria or fungi. If superinfection occurs, Clix 500 mg should be discontinued and appropriate therapy should be instituted.

Overdose Effects of Clix 500 mg

Reports indicate that the ingestion of large amounts of Clix 500 mg can be expected to produce gastro-intestinal symptoms. One patient who had a history of bipolar disorder ingested 8 grams of Clix 500 mg and showed altered mental status, paranoid behaviour, hypokalemia and hypoxemia. Adverse reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures. As with other macrolides, Clix 500 mg serum levels are not expected to be appreciably affected by haemodialysis or peritoneal dialysis.

Storage Conditions

Store in a cool and dry place, protected from light & moisture. The reconstituted suspension must be used within 7 days if kept at room temperature and within 14 days when stored in a refrigerator. Keep out of reach of children.

Use In Special Populations

Clix 500 mg may be used in neonates and children in appropriate doses.

Duration Of Treatment

Children older than 12 years and Adult: The usual duration of treatment is 6 to 14 days. Eradication of H. pylori in patients with duodenal ulcers: Adults: The usual duration of treatment is 6 to 14 days.

Reconstitution

45 ml of water is to be added to the granules in the bottle and shaken to yield 70 ml of reconstituted suspension. The concentration of Clix 500 mg in the reconstituted suspension is 125 mg per 5 ml.

Drug Classes

Macrolides

Mode Of Action

Clix 500 mg acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S subunit of the bacterial ribosome and preventing translocation to that site. Clix 500 mg is active against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas. Clix 500 mg's activity is the same as, or greater than, that of Erythromycin in vitro against most Gram-positive bacteria. Clix 500 mg is more acid-stable than Erythromycin and therefore, is better tolerated. Clix 500 mg has twice the activity of Erythromycin against H. influenzae. Most species of Gram-negative bacteria are resistant to Clix 500 mg because of failure to penetrate the target.

Pregnancy

The drug may be used in neonates and children in appropriate doses. Breast milk from mothers receiving Clix 500 mg should not be given to infants until treatment is completed. There is as yet little experience in the treatment of pregnant patients and Clix 500 mg is not recommended.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.