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A-Phenicol1%
ACME Laboratories Ltd.
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Conicol1%
Ophthalmic Ointment
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Medicine overview
Indications of Conicol 1%
Conicol 1% is indicated in Ocular infectionsBacterial meningitisAnaerobic bacterial infectionsAnthraxBrain abscessEhrlichiosisGas gangreneGranuloma inguinaleInfections caused by H. influenzaeListeriosisPlaguePsittacosisQ feverSevere gastroenteritisSevere melioidosisSevere systemic infections with Camphylobacter fetusTularaemiaWhipple's diseaseOtitis externa
Theropeutic Class
Ear Anti-Infectives & Antiseptics, Eye Anti-Infectives & Antiseptics, Macrolides
Pharmacology
Conicol 1% inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase.
Absorption
It has both bacteriostatic and bactericidal action against H.
Distribution
influenzae, N.
Metabolism
meningitidis and S.
Excretion
pneumoniae.
Dosage & Administration of Conicol 1%
For Eye
Dosage:Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes
Notes:If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician
For Ear
Dosage:2 to 3 drops into ear canal thrice or four times daily
Otic/Aural
Dosage:Otitis externa: Instill 2-3 drops of a 5% solution into the ear bid-tid
Oral
Dosage:Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H
Notes:influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple's disease: Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever
Child
Dosage:Premature and full-term neonates: 25 mg/kg/day in 4 divided doses
Full-term infants >2 wk
Dosage:50 mg/kg/day in 4 divided doses
Children
Dosage:50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections
| Condition | Dosage | Notes |
|---|---|---|
| For Eye | Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes | If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician |
| For Ear | 2 to 3 drops into ear canal thrice or four times daily | |
| Otic/Aural | Otitis externa: Instill 2-3 drops of a 5% solution into the ear bid-tid | |
| Oral | Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H | influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple's disease: Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever |
| Child | Premature and full-term neonates: 25 mg/kg/day in 4 divided doses | |
| Full-term infants >2 wk | 50 mg/kg/day in 4 divided doses | |
| Children | 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections |
Interaction of Conicol 1%
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of Conicol 1%. Impairs the action of oral contraceptives.
Contraindications
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
Side Effects of Conicol 1%
Oral: GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency.ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity.
Pregnancy & Lactation
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Precautions & Warnings
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Storage Conditions
Cap/susp: Store at temp not exceeding 30°C. Ophth/otic preparation: Store between 2-8°C. Do not freeze. Protect from light.
Frequently Asked Questions
What is Conicol 1% used for?
Chloramphenicol is indicated in Ocular infections, Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple's disease, Otitis externa
What is the dosage of Conicol 1%?
For Eye: Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes. If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician.For Ear: 2 to 3 drops into ear canal thrice or four time…
What are the side effects of Conicol 1%?
Oral: GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency.ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity.
Who should not take Conicol 1%?
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
What precautions should be taken with Conicol 1%?
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Is Conicol 1% safe during pregnancy and breastfeeding?
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.