Giran16 mg
Tablet
Medicine overview
Indications of Giran 16 mg
Theropeutic Class
Pharmacology
Giran 16 mg is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract.
Candesartan is angiotensin II receptor (type AT1) antagonist.
Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).
Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).
Dosage & Administration of Giran 16 mg
| Condition | Dosage | Notes |
|---|---|---|
| Hypertention | initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily | |
| Heart failure | initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose |
Dosage of Giran 16 mg
| Condition | Dosage | Notes |
|---|---|---|
| Hypertention | initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily | |
| Heart failure | initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose |
Interaction of Giran 16 mg
Contraindications
Side Effects of Giran 16 mg
Pregnancy & Lactation
Precautions & Warnings
Storage Conditions
Use In Special Populations
Drug Classes
Mode Of Action
Pregnancy
Pediatric Uses
Frequently Asked Questions
What is Giran 16 mg used for?
Candesartan Cilexetil is indicated for hypertension, heart failure with impaired left ventricular systolic function.
What is the dosage of Giran 16 mg?
Hypertention: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.
What are the side effects of Giran 16 mg?
Side-effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion (e.g. those taking high dose diuretics). Hyperkalemia occurs occassionally; angioedema has also been reported with some angiotension II receptor antagonist. Also vertigo, headache; rarely hepatitis, blood disorders, hyponatraemia, back pain, arthralgia,…
Who should not take Giran 16 mg?
Hypersensitivity to any component of this product. Pregnancy, breast-feeding, cholestasis.
What precautions should be taken with Giran 16 mg?
Candesartan should be used with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.
Is Giran 16 mg safe during pregnancy and breastfeeding?
When pregnancy is detected, Candesartan Cilexetil should be discontinued as soon as possible. It should be used in lactation.
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.