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Nidocard Spray400 mcg/sp
Drug International Ltd.
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Nitrocard400 mcg/spray
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Medicine overview
Indications of Nitrocard 400 mcg/spray
Nitrocard 400 mcg/spray sublingual tablet is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease
Theropeutic Class
Nitrates: Coronary vasodilators
Pharmacology
Nitrocard 400 mcg/spray forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3'5' monophosphate in smooth muscle and other tissues.
Absorption
These events lead to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle and result in vasodilatation.
Dosage & Administration of Nitrocard 400 mcg/spray
One sublingual tablet should be dissolved under the tongue at the first sign of an acute anginal attack. The dose may be repeated approximately every five minutes, until relief is obtained. If the pain persists after a total of 3 tablets in a 15-minute period, prompt medical attention is recommended.
Interaction of Nitrocard 400 mcg/spray
Patients receiving antihypertensive drugs, beta-adrenergic blockers or phenothiazines and nitrates should be observed for possible additive hypotensive effects. Marked orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used concomitantly. Concomitant use of nitrates and alcohol may cause hypotension. The vasodilatory and hemodynamic effects of Nitrocard 400 mcg/spray may be enhanced by concomitant administration of aspirin. Patients receiving sublingual Nitrocard 400 mcg/spray should avoid ergotamine and related drugs or be monitored for symptoms of ergotism if this is not possible.
Contraindications
Sublingual Nitrocard 400 mcg/spray therapy is contraindicated in patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to Nitrocard 400 mcg/spray. Administration of Nitrocard 400 mcg/spray is contraindicated in patients who are using sildenafil citrate since sildenafil citrate has been shown to potentiate the hypotensive effects of organic nitrates.
Side Effects of Nitrocard 400 mcg/spray
Headache which may be severe and persistent may occur immediately after use. Vertigo, dizziness, weakness, palpitation and other manifestations of postural hypotension may develop occasionally.
Pregnancy & Lactation
Nitrocard 400 mcg/spray should be given to a pregnant woman only if clearly needed. It is not known whether Nitrocard 400 mcg/spray is excreted in human milk.
Precautions & Warnings
Only the smallest dose required for effective control of the acute anginal attack should be used. Excessive use may lead to the development of tolerance. This drug should be used with caution in patients who may be volume-depleted or are alredy hypotensive.
Storage Conditions
Store in a cool and dry place away from light and heat. Keep all medicines out of the reach of children.
Frequently Asked Questions
What is Nitrocard 400 mcg/spray used for?
Nitroglycerin sublingual tablet is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease
What is the dosage of Nitrocard 400 mcg/spray?
One sublingual tablet should be dissolved under the tongue at the first sign of an acute anginal attack. The dose may be repeated approximately every five minutes, until relief is obtained. If the pain persists after a total of 3 tablets in a 15-minute period, prompt medical attention is recommended.
What are the side effects of Nitrocard 400 mcg/spray?
Headache which may be severe and persistent may occur immediately after use. Vertigo, dizziness, weakness, palpitation and other manifestations of postural hypotension may develop occasionally.
Who should not take Nitrocard 400 mcg/spray?
Sublingual Nitroglycerin therapy is contraindicated in patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to Nitroglycerin. Administration of Nitroglycerin is contraindicated in patients who are using sildenafil citrate since sildenafil citrate has been shown to potentiate the hypotensive effects of organic nitrates.
What precautions should be taken with Nitrocard 400 mcg/spray?
Only the smallest dose required for effective control of the acute anginal attack should be used. Excessive use may lead to the development of tolerance. This drug should be used with caution in patients who may be volume-depleted or are alredy hypotensive.
Is Nitrocard 400 mcg/spray safe during pregnancy and breastfeeding?
Nitroglycerin should be given to a pregnant woman only if clearly needed. It is not known whether Nitroglycerin is excreted in human milk.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.