Ovacare1250UI+ 100mg+ 75mg

Ovacare is a fixed-dose combination of folic acid (vitamin B9), vitamin B12 (cobalamin), and vitamin B6 (pyridoxine) used for the following indications:

Established uses

• Prevention and treatment of dietary deficiency of folic acid, vitamin B12, and vitamin B6, particularly in individuals with poor dietary intake, malabsorption, pregnancy, lactation, or increased metabolic demand.
• Supportive therapy for megaloblastic anemia due to combined folate and vitamin B12 deficiency, as an adjunct to identifying and treating the underlying cause.
• Support of normal red blood cell formation and neurological (nerve) function, especially in patients with subclinical or mild combined B-vitamin deficiency.

Guideline-supported / adjunct uses

• Adjunct management of elevated plasma homocysteine levels, where folic acid, vitamin B12, and vitamin B6 act together in homocysteine metabolism (clinical benefit on cardiovascular outcomes has not been definitively established).
• Nutritional support in peripheral neuropathy associated with B-vitamin deficiency (e.g., in malnourished, elderly, or alcohol-dependent patients), as an adjunct to treating the underlying cause.
• Supplementation during pregnancy and lactation to help meet increased requirements for folic acid, vitamin B12, and vitamin B6 (folic acid is specifically recommended by health authorities before and during early pregnancy to reduce the risk of neural tube defects).

Ovacare is a nutritional supplement and is not intended to replace treatment of the specific underlying cause of anemia or neuropathy (e.g., pernicious anemia requiring long-term parenteral B12, malignancy, or other structural disease), which should be evaluated separately by a physician.

Each unit of Folic Acid, Vit.B12, B6 typically contains:

• Folic acid (Vitamin B9)
• Vitamin B12 (Cyanocobalamin/Methylcobalamin)
• Vitamin B6 (Pyridoxine hydrochloride)

Exact strengths vary by brand and formulation (tablet, capsule, or oral solution); refer to the product label for the specific amount of each vitamin.

Ovacare is a multivitamin combination product that supplies three water-soluble B-group vitamins that work together in one-carbon and amino acid metabolism:

• Folic acid is required for DNA synthesis and red blood cell maturation.
• Vitamin B12 is essential for red blood cell formation, DNA synthesis, and maintenance of the myelin sheath of nerve cells.
• Vitamin B6 is a cofactor for enzymes involved in amino acid metabolism, neurotransmitter synthesis, and hemoglobin production.

Because deficiency of any one of these vitamins can produce overlapping hematologic and neurological effects, Ovacare is formulated to address combined deficiency and support normal blood and nerve function.

Ovacare belongs to the therapeutic class of vitamin B-complex nutritional supplements / hematinics, used for prevention and treatment of B-vitamin deficiency.

Folic Acid, Vit.B12, B6 combines three vitamins with complementary roles in cellular metabolism:

• Folic acid is converted to its active form, tetrahydrofolate, which acts as a coenzyme in the transfer of one-carbon units required for purine and pyrimidine (DNA) synthesis and for the conversion of homocysteine to methionine.
• Vitamin B12 (cobalamin) acts as a cofactor for methionine synthase (regenerating tetrahydrofolate from its methylated form, thereby supporting folate metabolism) and for methylmalonyl-CoA mutase, which is important for fatty acid and myelin metabolism. B12 deficiency impairs DNA synthesis in rapidly dividing cells (causing megaloblastic anemia) and can cause demyelination of peripheral nerves and the spinal cord.
• Vitamin B6 (pyridoxine) is converted to pyridoxal-5-phosphate, a coenzyme required for transamination and decarboxylation reactions in amino acid metabolism, synthesis of neurotransmitters (e.g., serotonin, dopamine, GABA), heme synthesis, and the transsulfuration pathway that helps clear homocysteine.

Together, these three vitamins support normal erythropoiesis (red blood cell production), nervous system function, and homocysteine metabolism.

Take Ovacare by mouth, with or after food, at approximately the same time each day to maintain consistent blood levels. Do not take more than the recommended dose. If a dose is missed, take it as soon as remembered unless it is close to the time for the next dose, in which case skip the missed dose; do not double the dose.

Ovacare should be used with caution in patients taking the following medicines, due to well-recognized interactions:

• Phenytoin, phenobarbital, primidone (anticonvulsants): Folic acid may lower plasma levels of these anticonvulsants and reduce seizure control; conversely, these drugs can reduce folate levels. Monitor anticonvulsant levels and seizure control if used together.
• Levodopa (without carbidopa): Vitamin B6 can reduce the therapeutic effect of levodopa by increasing its peripheral breakdown. This interaction is not significant with levodopa-carbidopa combinations.
• Methotrexate and other folate antagonists: Folic acid may reduce the antifolate/therapeutic effect of methotrexate; concurrent use should only be done under direct physician supervision.
• Metformin, proton pump inhibitors (PPIs), and H2-receptor antagonists: Long-term use of these drugs can reduce vitamin B12 absorption; patients on these medicines may need periodic B12 status monitoring even while supplementing with Ovacare.
• Chloramphenicol: May antagonize the hematologic response to vitamin B12 therapy.

Inform the physician or pharmacist about all other medicines being taken before starting Ovacare.

Ovacare is generally well tolerated when taken at recommended doses. Reported side effects include:

• Common: Mild gastrointestinal discomfort (nausea, bloating, loss of appetite), altered taste.
• Uncommon: Skin rash or itching due to hypersensitivity.
• Rare: Allergic reactions (including flushing and, rarely, anaphylactoid reactions, more often reported with parenteral vitamin B12); sensory peripheral neuropathy with prolonged high-dose vitamin B6 use (see Precautions and Warnings).

Seek medical attention if signs of an allergic reaction (swelling, difficulty breathing, severe rash) occur.

Folic acid supplementation is specifically recommended by health authorities before conception and during early pregnancy to reduce the risk of fetal neural tube defects, and requirements for vitamin B12 and vitamin B6 also increase during pregnancy and lactation. However, Ovacare as a combination product should be used in pregnancy and lactation only as advised by a physician, who can confirm the appropriate dose for each vitamin is appropriate for the trimester and individual needs. Use only if clearly needed and the potential benefit justifies the potential risk; avoid doses higher than recommended without medical supervision.

Use Ovacare with the following precautions:

• Folic acid supplementation can improve the anemia of vitamin B12 deficiency (e.g., pernicious anemia) while allowing the underlying neurological damage from B12 deficiency to progress; because Ovacare contains B12 as well, this risk is reduced, but any suspected pernicious anemia should still be properly diagnosed and, if needed, treated with physician-directed parenteral B12.
• Prolonged use of high-dose vitamin B6 (well above recommended supplement doses) has been associated with sensory peripheral neuropathy, which is usually reversible on stopping the vitamin. Do not exceed the recommended dose or duration without medical advice.
• Use with caution in patients with known hypersensitivity to cobalt or cobalamin derivatives.
• Ovacare is a nutritional supplement, not a substitute for investigating and treating the underlying cause of anemia, neuropathy, or elevated homocysteine.

Acute overdose with Ovacare is unlikely to be life-threatening because folic acid, vitamin B12, and vitamin B6 are water-soluble and excess amounts are largely excreted in urine; however, chronic excessive intake of vitamin B6 has been associated with sensory neuropathy. If a significant overdose is suspected or symptoms such as numbness, tingling, or difficulty with coordination develop, seek immediate medical attention or contact a poison control center; do not attempt unsupervised home treatment.

Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.

Pregnant and breastfeeding women

See Pregnancy and Lactation; folic acid is specifically recommended during pregnancy, and Ovacare should be used at physician-directed doses.

Elderly

Older adults are at higher risk of vitamin B12 deficiency due to reduced absorption; Ovacare may be used for supplementation, with periodic monitoring of B12 status where clinically indicated.

Renal impairment

No specific dose adjustment is generally required for water-soluble B vitamins in mild-to-moderate renal impairment; use with physician guidance in significant renal impairment.

Hepatic impairment

No well-established dose adjustment is required; use with physician guidance.

Children

Use in children should be under pediatric supervision, with dosing individualized to age and weight; safety and efficacy of a fixed adult-strength combination have not been established in young children (see Pediatric Uses).

Duration of treatment with Ovacare depends on the indication: dietary supplementation may be continued long-term (e.g., throughout pregnancy and lactation) as advised, while treatment of a confirmed deficiency is usually continued until laboratory parameters and symptoms normalize, followed by physician reassessment for maintenance therapy.

Folic Acid, Vit.B12, B6 belongs to the drug class of vitamin B-complex supplements (folic acid, vitamin B12, and vitamin B6 combination).

Folic Acid, Vit.B12, B6 works by replenishing folic acid, vitamin B12, and vitamin B6, which act as essential coenzymes and cofactors in DNA synthesis, red blood cell maturation, amino acid metabolism, neurotransmitter synthesis, and homocysteine clearance. Correcting deficiency of these vitamins restores normal erythropoiesis and supports healthy nerve function.

Ovacare may be used in children under pediatric supervision for confirmed or suspected dietary deficiency of folic acid, vitamin B12, or vitamin B6, with the dose individualized according to age and body weight. Safety and efficacy of the specific fixed-dose adult-strength combination have not been formally established in infants and young children; a physician should select an age-appropriate formulation and dose.